A5058790331- Evolution and Genetic Dynamics
- Effects of Radiation Exposure
- Genetic diversity and population structure
- Protist diversity and phylogeny
- Aquatic Ecosystems and Phytoplankton Dynamics
- Radiation Therapy and Dosimetry
- Genomics and Phylogenetic Studies
- Physiological and biochemical adaptations
- Plant-Microbe Interactions and Immunity
- Plant Pathogens and Fungal Diseases
- Insect symbiosis and bacterial influences
- Spaceflight effects on biology
- Genome Rearrangement Algorithms
- Chromosomal and Genetic Variations
- Biochemical effects in animals
- Fungal Biology and Applications
- Plant Parasitism and Resistance
- DNA Repair Mechanisms
- Plant and animal studies
- Photosynthetic Processes and Mechanisms
- Mycorrhizal Fungi and Plant Interactions
- Plant Genetic and Mutation Studies
- CRISPR and Genetic Engineering
- Fungal and yeast genetics research
- Plant Stress Responses and Tolerance
Skolkovo Institute of Science and Technology
2018-2020
Institute for Information Transmission Problems
2016-2019
Institute of Theoretical and Experimental Biophysics
2009-2016
Pirogov Russian National Research Medical University
2016
Russian Academy of Sciences
2011-2013
Lomonosov Moscow State University
2013
The genome of the asexual rotifer Adineta vaga lacks homologous chromosomes; instead, its allelic regions are rearranged and sometimes found on same chromosome in a palindromic fashion, structure reminiscent primate Y other mitotic lineages such as cancer cells. Bdelloid rotifers thought to have persisted diversified asexually for millions years, which is odd because loss sexual reproduction widely considered be an evolutionary dead end metazoans. suspicion remained that they might engage...
Negative selection against deleterious alleles produced by mutation influences within-population variation as the most pervasive form of natural selection. However, it is not known whether affect fitness independently, so that cumulative loss depends exponentially on number alleles, or synergistically, each additional allele results in a larger decrease relative fitness. with synergistic epistasis should produce negative linkage disequilibrium between and, therefore, an underdispersed...
Abstract Sexual reproduction is almost ubiquitous among extant eukaryotes. As most asexual lineages are short-lived, abandoning sex commonly regarded as an evolutionary dead end. Still, putative anciently challenge this view. One of the striking examples bdelloid rotifers, microscopic freshwater invertebrates believed to have completely abandoned sexual tens Myr ago. Here, we compare whole genomes 11 wild-caught individuals rotifer Adineta vaga and present evidence that some patterns in its...
Conservation of function can be accompanied by obvious similarity homologous sequences which may persist for billions years (Iyer LM, Leipe DD, Koonin EV, Aravind L. 2004. Evolutionary history and higher order classification AAA+ ATPases. J Struct Biol. 146:11-31.). However, presumably segments noncoding DNA also retain their ancestral even after diverge beyond recognition (Fisher S, Grice EA, Vinton RM, Bessling SL, McCallion AS. 2006. RET regulatory from human to zebrafish without sequence...
Sexual reproduction which involves alternation of meiosis and syngamy is the ancestral condition extant eukaryotes. Transitions to asexual were numerous, but most resulting eukaryotic lineages are rather short-lived. Still, there several exceptions this rule including darwinulid ostracods 1,2 timema stick insects 3 . The striking them bdelloid rotifers 4 – 6 , microscopic freshwater invertebrates underwent an extensive adaptive radiation after apparently losing over 10 Mya. Indeed, both lack...
In the present work, delayed effects of chronic high linear energy transfer (LET) radiation in polychromatic erythrocytes (PCEs) mice bone marrow were investigated vivo. Irradiation two-month-old SHK white mongrel random-bred male was performed field behind concrete shield accelerator 70 GeV protons to accumulate doses 0.005–0.16 Gy. The dependence biological response on dose, adaptive (AR) and genomic instability (GI) F1 F2 generations from males irradiated with 0.005 0.16 Gy exposed...
Abstract Negative selection against deleterious alleles produced by mutation is the most common form of natural selection, which strongly influences within-population variation and interspecific divergence. However, some fundamental properties negative remain obscure. In particular, it still not known whether affect fitness independently, so that cumulative loss depends exponentially on number alleles, or synergistically, each additional allele results in a larger decrease relative fitness....
Abstract Podospora anserina is a model ascomycetous fungus which shows pronounced phenotypic senescence when grown on solid medium but possesses unlimited lifespan under submerged cultivation. In order to study the genetic aspects of adaptation P. cultivation, we initiated long-term evolution experiment. course first 4 years experiment, 125 single-nucleotide substitutions and 23 short indels were fixed in eight independently evolving populations. Six proteins that affect fungal growth...
The effect of a low dose-rate high Linear Energy Transfer (LET) radiation that simulates the spectral and component composition fields formed in conditions high-altitude flights on mice vivo has been investigated. dose dependence, Adaptive Response (AR) Genetic Instability (GI) bone marrow generation F1 born from males irradiated under these were examined using micronucleus test. Irradiation was performed field behind concrete shield U-70 accelerator to accumulate doses 11.5, 21.5 31.5 cGy...
Abstract Podospora anserina is a model ascomycetous fungus which shows pronounced phenotypic senescence when grown on solid medium but possesses unlimited lifespan under submerged cultivation. In order to study the genetic aspects of adaptation P. cultivation, we initiated long-term evolution experiment. course first four years experiment, 125 single-nucleotide substitutions and 23 short indels were fixed in eight independently evolving populations. Six proteins that affect fungal growth...