A5035000099- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Marine Sponges and Natural Products
- Sulfur Compounds in Biology
- Neuroblastoma Research and Treatments
- Synthetic Organic Chemistry Methods
- Glutathione Transferases and Polymorphisms
- Drug Transport and Resistance Mechanisms
- Microbial Natural Products and Biosynthesis
University Hospital Carl Gustav Carus
2020-2024
Technische Universität Dresden
2020-2024
Aggressive pheochromocytomas and paragangliomas (PPGLs) are difficult to treat, molecular targeting is being increasingly considered, but with variable results. This study investigates established novel molecular-targeted drugs chemotherapeutic agents for the treatment of PPGLs in human primary cultures murine cell line spheroids. In from 33 patients, including 7 metastatic PPGLs, we identified germline or somatic driver mutations 79% cases, allowing us assess potential differences drug...
Reduced and oxidized glutathione play an important role for the intracellular detoxification of reactive oxygen species. The iron-dependent formation such species in conjunction with inhibition redox-balancing enzyme peroxidase 4 underlie imbalance cellular redox state, thereby resulting a non-apoptotic form cell death, defined as ferroptosis, which is relevant several pathologies.
Novel strategies to treat cancer effectively without adverse effects on the surrounding normal tissue are urgently needed. Marine sponges provide a natural and renewable source of promising anti-tumor agents. Here, we investigated activity Aerothionin Homoaerothionin, two bromotyrosines isolated from marine demosponge Aplysina cavernicola, mouse pheochromocytoma cells, MPC MTT. To determine therapeutic window these metabolites, furthermore explored their cytotoxicity cells tissue. Both...
Continuous activation of hypoxia pathways in pheochromocytomas and paragangliomas (PPGLs) is associated with higher disease aggressiveness, for which effective treatment strategies are still missing. Most the commonly used vitro models lack characteristics these pseudohypoxic tumors, including elevated expression hypoxia-inducible factor (HIF) 2α. To address this shortcoming, we investigated whether recurrent cycles lead to continuous under normoxic conditions pseudohypoxia increased...