Familial hypercholesterolemia is an autosomal dominant disorder of lipid metabolism, leading to increase in plasma low-density lipoprotein cholesterol, followed by premature atherosclerosis. In women with familial hypercholesterolemia, pregnancy and lactation pose additional risk due the association physiological changes, pre-existing dyslipidemia, limited therapeutic options experience. A clinical case successful management a pregnant woman against background multifocal atherosclerosis...

To study the impact of a polymorphic variant matrix metalloproteinase-3 (MMP-3) gene on development and course chronic heart failure (CHF) in patients with coronary disease.A total 277 New York Heart Association (NYHA) Functional Class (FC) II-IV CHF were examined. MMP-3 -1171 5A/6A genetic polymorphism was studied by polymerase chain reaction. A control group included 136 (mean age 53.6 ± 4.8 years) no signs cardiovascular diseases, as evidenced examination.The frequency 5A allele 5A/5A...

Aim. The purpose of this study was to examine the incidence early and late cardiotoxicity in women receiving anthracycline antibiotics during breast cancer chemotherapy treatment as well possible links anthracycline-induced cardiomyopathy with endothelial dysfunction inflammation. Materials methods. A 12-month cohort included 148 who received a part regimens. Echocardiography ultrasound examination brachial artery were performed all patients before chemotherapy, after first round therapy,...

Aim.. To study clinical and pathogenic relationships between the development of chronic heart failure (CHF) ischemic genesis associated with type 2 diabetes mellitus (DM) osteoporosis in postmenopausal women to evaluate effects anti-osteoporotic therapy on CHFMethods Methods. A total 178 were recruited study. All patients assigned three groups: Group 1 (n = 48) CHF DM, 93) – CHF, 3 37) osteoporosis, mellitus. The control group comprised 35 healthy period without signs symptoms cardiovascular...

Aim . To study the interrelation between hyperhomocysteinemia, expression of endothelin-1, Fas-ligand (Fas-L), atrial natriuretic peptide (NT-proBNP) and severity course chronic heart failure (CHF) in patients with coronary disease (CHD) during 12-month prospective to develop forecasting models probability adverse cardiovascular events depending on gender. Materials methods. The included 94 CHF. control group 32 people who did not have disorders. At baseline after 12 months observation blood...

Aim To evaluate the predictive significance of gene polymorphism in endothelin-1 type 2A receptor, NADPH oxidase, p53 protein, endothelial nitric oxide synthase, caspase 8, interleukin-1β, tumor necrosis factor-α, superoxide dismutase-2, glutathione peroxidase-1, β1-adrenoceptor, angiotensin-converting enzyme, and matrix metalloproteinase-3 (MMP-3) genes evaluating risk anthracycline-induced cardiotoxicity (AIC) women without concurrent cardiovascular diseases (CVD). Material methods This...

Aim. To study the mechanisms, features of clinical manifestations and predicting cardiotoxicity resulting from anthracycline chemotherapy. Material methods. We examined 176 women with breast cancer who received antibiotics as part polychemotherapeutic (PCT) treatment. Patients were divided into 2 groups: development cardiotoxic remodeling — group 1 (n=52) preserved heart function (n=124). conducted echocardiographic (EchoCG) tests before start, during after In serum termination PCT...

Objective . To study the pathogenetic and prognostic role of cytokines (tumor necrosis factor-α (TNF-α) interleukin-1β (IL-1β)) in development anthracycline-induced chronic heart failure (CHF). Material Methods A total 176 women with breast cancer who received anthracycline antibiotics as a part polychemotherapy regimens were examined. Upon examination, patients remission divided into two groups within 12 months after completion chemotherapy: cardiotoxic remodeling (group 1, n = 52)...

Aim. To reveal the specific features of Fas ligand-mediated ischemic myocardial remodeling and those chronic heart failure (CHF) development during a 12-month prospective follow-up. Subjects methods. A total 94 patients with CHF were examined divided into 3 groups according to NYHA Functional Class (FC): 1) FC II in 35 patients; 2) III 31; 3) IV 28. According results follow-up, randomized 2 groups: A) 49 favorable course cardiovascular disease B) 45 its poor course. Serum soluble ligand...

Aim. To study the influence of brain natriuretic peptide gene polymorphism (polymorphic locus Т-381С) on serum level and congestive heart failure onset risk clinical features in patients with coronary disease. Methods. 412 were examined. Genotyping was performed by polymerase chain reaction. Brain N-terminal fragment assessed ELISA. The control group included 211 healthy controls no signs cardiovascular pathology examination. Results. In people C/C genotype significantly higher comparison...

Aim. To study the influence of polymorphism gene methyltetrahydrofolate-reductase (MTHFR) — polymorhic locus С 677 Т , and level homocysteine in blood plasma on risk development course chronic heart failure (CHF). Material methods. Totally, 277 persons studied with CHF II-IV functional classes (FC NYHA). The MTHFR via polymerase chain reaction. With aim to reveal association patients were selected by results year-long observation 2 groups: benign (n=49) adverse (n=45) course. During period...

To study the prognostic significance of polymorphism p53 gene (polymorphism Arg72Pro exon 4, rs1042522) on development cardiotoxic remodeling left ventricle and heart failure.A total 176 women with breast cancer who received anthracycline antibiotics as part polychemotherapeutic treatment regimens were examined. Based results survey, 12 months after end polychemotherapy, patients in remission underlying disease divided into 2 groups: (52 patients) preserved function (124 patients). All...

Aim. To evaluate the role of polymorphisms in adrenoceptor beta 1 ( ADRB1 ) (Arg389Gly, rs1801253) and angiotensin-converting enzyme (ACE) (I/D, rs4343) genes assessing effectiveness β-blocker (carvedilol) ACE inhibitor (enalapril) therapy women with anthracycline-induced cardiotoxicity (AIC) without prior cardiovascular diseases (CVD) during 12-month follow-up. Materials methods. A total 82 (average age 45.0 (42.0; 50.0) years) AIC CVD were included study. Echocardiography was performed...

Aim. To carry out a 12-month study on the prognostic role of humoral markers responsible for main mechanisms initiation cardiotoxic myocardial damage (endothelin-1, soluble Fas-L, N-terminal pro-brain natriuretic peptide (NT-proBNP), tumor necrosis factor-α, interleukin (IL)-1β, matrix metalloproteinase (MMP)-2 and MMP9, form ST2 protein (sST2), tissue inhibitor metalloproteinase-1, tetranectin) in assessing risk progression anthracycline-related left ventricular dysfunction. Materials...

This study demonstrates the relationship between IgG titer to cytomegalovirus (CMV) and proinflammatory cytokine TNF-α IL-1β concentration, prognosis after hospitalization of patients due decompensation chronic heart failure (CHF) during 24 months observation. Material methods . We examined 132 with CHF ischemic etiology (age 59.0 [54.0; 63.5] year, median [lower quartile; upper quartile]), hospitalized for decompensation. Patients were included in stabilization before discharge from...

Aim. To study the characteristics of course arterial hypertension (AH) and subclinical cardiac damage during breast cancer chemotherapy with doxorubicin. Materials methods. The included a total 27 women (BC) history controlled who were to receive anthracyclines. Twelve had stage 1 hypertension; 15 2 hypertension. patients received dual antihypertensive therapy according clinical guidelines. All underwent echocardiography 24-hour blood pressure monitoring at baseline, after last chemotherapy,...

Current recommendations for the primary prevention of chemotherapy cardiotoxicity are based on stratification risk cardiovascular complications before anticancer treatment is initiated. The proposed scores take into account presence existing diseases, but do not therapy used these diseases. Two clinical cases patients with tumor diseases presented. One patient had a high cardiotoxicity, even detection process, he received β-blocker, an angiotensin receptor blocker and statin as strategy...

Aim To study the role of soluble ST2 (sST2), N-terminal pro-brain natriuretic peptide (NT-proBNP), and С-reactive protein (CRP) in patients with chronic heart failure preserved left ventricular ejection fraction (CHF pLVEF) syndrome obstructive sleep apnea (SOSA) stratification risk for development cardiovascular complications (CVC) during one month a prospective observation. Material methods The included 71 men SOSA an apnea/hypopnea index (AHI) >15 per hour, abdominal obesity, arterial...

Aim. To study the clinical and genetic aspects of influence polymorphic variants genes endothelial NO-synthase (NOS3), receptor endothelin-1 type A (EDNRA) NADPH-oxidase on development cardiotoxic remodeling left ventricle heart failure during anthracycline-based regimens for patients with breast cancer. Methods. 176 women cancer receiving anthracycline antibiotics as part multiple drug chemotherapy were examined. According to results examination, 12 months after end chemotherapy, all main...

Aim. To study the link of increased serum concentrations osteoprotegerin (OPG) in patients with chronic heart failure (CHF) associated type 2 diabetes mellitus (DM 2), osteoporosis or osteopenia development cardiovascular events (primarily, decompensation CHF, including those requiring hospitalization, death from disease, acute coronary syndrome ischemic stroke) to determine possibility using this biomarker as a predictor severe course disease these patients. Materials and methods. In...

To study the effectiveness of oral alendronate and ibandronate bisphosphonates for prevention cardiovascular complications in postmenopausal women with type 2 diabetes mellitus (DM) osteoporosis during a 12-month prospective observation.The included 86 osteoporosis, chronic heart failure (CHF) diabetes: 1st group (n=52) patients who received basic therapy failure; 2nd (n=34) who, addition to failure, were prescribed alendronic ibandronic acid preparations treatment osteoporosis. In order...