A5075825354- Axon Guidance and Neuronal Signaling
- Apelin-related biomedical research
- Metabolomics and Mass Spectrometry Studies
- Bone health and osteoporosis research
- Genetic Associations and Epidemiology
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Folate and B Vitamins Research
- Retinopathy of Prematurity Studies
- Nuclear Receptors and Signaling
- Hedgehog Signaling Pathway Studies
- Ocular Diseases and Behçet’s Syndrome
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Nitric Oxide and Endothelin Effects
- Circular RNAs in diseases
- Vitamin D Research Studies
- Systemic Lupus Erythematosus Research
- Saffron Plant Research Studies
- Inflammatory Bowel Disease
- Cystic Fibrosis Research Advances
- Retinal and Optic Conditions
- Zebrafish Biomedical Research Applications
Jewish General Hospital
2017-2023
Galapagos (Belgium)
2022-2023
McGill University
2017-2022
Hôpital Maisonneuve-Rosemont
2011-2019
Université de Montréal
2013-2019
The deterioration of the inner blood-retinal barrier and consequent macular edema is a cardinal manifestation diabetic retinopathy (DR) clinical feature most closely associated with loss sight. We provide evidence from both human animal studies for critical role classical neuronal guidance cue, semaphorin 3A, in instigating pathological vascular permeability retinas via its cognate receptor neuropilin-1. reveal that 3A induced early hyperglycemic phases diabetes within retina precipitates...
Significance Diabetic retinopathy is a major cause of blindness in the working population. The most common visual impairment diabetic patients macular edema (DME). Roughly 40% with DME respond poorly to anti-VEGF therapies, which are standard care. Here we provide mechanistic insight for critical role NOTCH1 signaling compromising endothelial junction integrity during diabetes. Besides activating canonical transcriptional pathways, find that also provokes disruption junctions via...
Immunological activity in the CNS is largely dependent on an innate immune response and heightened diseases, such as diabetic retinopathy, multiple sclerosis, amyotrophic lateral Alzheimer’s disease. The molecular dynamics governing cell recruitment to sites of injury disease during sterile inflammation remain poorly defined. Here, we identified a subset mononuclear phagocytes (MPs) that responds local chemotactic cues are conserved among central neurons, vessels, cells. Patients suffering...
The metabolic state of the body can be a major determinant bone health. We used Mendelian randomization approach to identify metabolites causally associated with mass better understand biological mechanisms osteoporosis. tested phenotypes (femoral neck, total hip, and lumbar spine mineral density [BMD]) for association 280 fasting blood in 6055 women from TwinsUK cohort genomewide genotyping scans. Causal associations between were further assessed bidirectional study using genetic...
Diabetic retinopathy (DR) is a major complication of diabetes and leading cause blindness in the working-age population. Impaired blood-retinal barrier function leads to macular edema that closely associated with deterioration central vision. We previously demonstrated neuronal guidance cue netrin-1 activates program reparative angiogenesis microglia within ischemic retina. Here, we provide evidence both vitreous humor diabetic patients retina murine model metabolized into bioactive fragment...
Background Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal fibrotic interstitial lung disease. Few circulating biomarkers have been identified to causal effects on IPF. Methods To identify candidate IPF-influencing proteins, we undertook an efficient screen of proteins by applying two-sample Mendelian randomisation (MR) approach with existing publicly available data. For instruments, used genetic determinants which reside cis the encoded gene ( -single nucleotide polymorphisms...
Idiopathic pulmonary fibrosis (IPF) is a progressive form of fibrosing interstitial pneumonia with poor survival. This study provides insight into the epidemiology, cost, and disease course IPF in Germany.A cohort incident patients (n = 1737) was identified from German claims data (2014-2019). Incidence prevalence rates were calculated adjusted for age differences compared overall population. All-cause IPF-related healthcare resource utilization as well associated costs evaluated per...
Abstract Background: Tobacco exposure causes 8 of 10 lung cancers, and identifying additional risk factors is challenging due to confounding introduced by smoking in traditional observational studies. Materials Methods: We used Mendelian randomization (MR) screen 207 metabolites for their role cancer predisposition using independent genome-wide association studies (GWAS) blood metabolite levels (n = 7,824) 29,266 cases/56,450 controls). A nested case–control study (656 cases 1,296 matched...
The rodent retina is perhaps the most accessible mammalian system in which to investigate neurovascular interplay within central nervous (CNS). It increasingly being recognized that several neurodegenerative diseases such as Alzheimer's, multiple sclerosis, and amyotrophic lateral sclerosis present elements of vascular compromise. In addition, prominent causes blindness pediatric working age populations (retinopathy prematurity diabetic retinopathy, respectively) are characterized by...
The rodent retina is perhaps the most accessible mammalian system in which to investigate neurovascular interplay within central nervous (CNS). It increasingly being recognized that several neurodegenerative diseases such as Alzheimer's, multiple sclerosis, and amyotrophic lateral sclerosis present elements of vascular compromise. In addition, prominent causes blindness pediatric working age populations (retinopathy prematurity diabetic retinopathy, respectively) are characterized by...
Abstract Background/Aims The safety profile of filgotinib (FIL), a second-generation oral Janus kinase (JAK) 1 preferential inhibitor approved in Europe, Japan, and the UK for treatment rheumatoid arthritis (RA) has been reported. In patients (pts) with active RA aged ≥50y ≥1 cardiovascular (CV) risk factor, treated pan-JAK tofacitinib, data from an interventional post-marketing study (NCT02092467) suggested higher major adverse events (MACE) malignancies compared TNF inhibitors. No are...