A5060727378- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Genomics and Phylogenetic Studies
- Drug Transport and Resistance Mechanisms
- RNA and protein synthesis mechanisms
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
Hefei National Center for Physical Sciences at Nanoscale
2014-2018
University of Science and Technology of China
2014-2018
Hefei Institutes of Physical Science
2017
The spr0693-spr0694-spr0695 operon of Streptococcus pneumoniae encodes a putative ATP-binding cassette (ABC)-type efflux pump involved in the resistance antibiotics and antimicrobial peptides. Here we report crystal structures Spr0694-0695 at 3.3 Å Spr0693 3.0 resolution, revealing MacAB-like pump. dimeric adopts non-canonical fold ABC transporter, transmembrane domain which consists eight tightly packed helices with an insertion extracellular between first second helices, whereas forms...