A5047749742- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- T-cell and B-cell Immunology
- Ubiquitin and proteasome pathways
- Telomeres, Telomerase, and Senescence
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Protein Degradation and Inhibitors
- Extracellular vesicles in disease
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Signaling Pathways in Disease
- Bone health and treatments
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Circular RNAs in diseases
- Chronic Lymphocytic Leukemia Research
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Adenosine and Purinergic Signaling
- Immunodeficiency and Autoimmune Disorders
- Mesenchymal stem cell research
- Cytokine Signaling Pathways and Interactions
- Drug Transport and Resistance Mechanisms
Polish Academy of Sciences
2015-2025
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy
2015-2025
Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase that maintains genome stability by maintaining telomere length (TL). The massive proliferation donor cells in the recipient's body for engraftment results accelerated shortening. Genetic variability within TERT gene affects activity, and was shown to influence haematopoietic stem cell transplantation (HSCT) outcome. In present study, we aimed analyse effect recipient TL single nucleotide polymorphism (SNP) on...
BCL-2 family proteins regulate apoptosis, while programmed cell death protein 1 (PD-1) and death-ligand (PD-L1) act as negative regulators of the immune system. An association has been found between abnormalities in B-cell CLL/lymphoma 2 (BCL-2) PD-1/PD-L1 susceptibility to myelodysplastic neoplasms. The aim this study was assess polymorphisms genes encoding BCL-2, PD-1, PD-L1, their impact on clinical course neoplasms (MDS), treatment effectiveness, correlation with other prognostic factors...
<title>Abstract</title> Graft-versus-host disease (GvHD) and cytomegalovirus (CMV) infection are serious complications after allogeneic hematopoietic stem cell transplantation (HSCT) NK cells involved in their pathogenesis. As granzyme B (GzmB) perforin markers of cytotoxicity, we examined polymorphism expression GzmB genes the context HSCT outcome. A number 247 patients 117 donors were genotyped for <italic>GZMB</italic> rs8192917 <italic>PRF1</italic> rs885822 variants, mRNA as well serum...
Multiple myeloma is a neoplastic disease characterised by the proliferation of clonal, atypical plasma cells. In cancer cells, balance between two paths cell death, necroptosis and apoptosis, disrupted. The aim this study was to analyse occurrence polymorphisms in genes encoding key proteins for process, i.e., RIPK-1, RIPK-3 MAPKAPK2. We investigated potential relations genetic variability clinical course disease. analysed six single-nucleotide population patients with multiple (n = 205)...
Background.Chronic graft-versus-host disease (cGvHD) is a complex disorder that typically manifests after allogeneic hematopoietic stem cell transplantation (HSCT).It major cause of non-relapse mortality, which makes finding biomarkers associated with its occurrence priority.Recent studies increasingly indicate microRNAs (miRNAs, short regulatory RNA molecules) can be used as various disorders.They circulate in patients' bodies encapsulated within extracellular vesicles (EVs).Objectives.To...
Basigin (BSG, CD147) is a multifunctional protein involved in cancer cell survival, mostly by controlling lactate transport through its interaction with monocarboxylate transporters (MCTs) such as MCT1. Previous studies have found that single nucleotide polymorphisms (SNPs) the gene coding for BSG and MCT1, well levels of soluble form (sBSG), are potential biomarkers various diseases. The goal this study was to confirm MCT1 RNA overexpression AML lines, analyse selected BSG/MCT1 genetic...
Multiple myeloma (MM) is a haematologic malignancy characterized by the presence of atypical plasma cells. Basigin (BSG, CD147) controls lactate export through monocarboxylic acid transporter 1 (MCT1, SLC16A1) and supports MM survival proliferation. Additionally, BSG implicated in response to treatment with immunomodulatory drugs (thalidomide its derivatives). We investigated role single nucleotide polymorphisms (SNPs) gene coding for SLC16A1 MM. Following an silico analysis, eight SNPs...
Multiple myeloma (MM) is a plasma-cell malignancy derived from an early precursor of the B-cell lineage characterised by bone-marrow infiltration, lytic bone lesions, and presence monoclonal protein in serum and/or urine. Interferon regulatory factor 4 (IRF4) critical transcriptional regulator development function that required during immune response for lymphocyte activation generation immunoglobulin-secreting plasma cells. Immunomodulatory drugs, derivatives thalidomide, are commonly used...
Acute myeloid leukaemia (AML) is a neoplasm of immature cells characterized by various cytogenetic alterations. The present study showed that in addition to the FLT3-ITD and NPM1 mutation status, telomere length (TL) telomerase reverse transcriptase (TERT) gene polymorphisms may affect risk overall survival (OS) AML. TL was longer healthy controls than AML patients positively correlated with age patients, but not subjects. found be independently affected presence mutation. As for TERT...
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) belong to the most common inflammatory rheumatic diseases. MicroRNAs (miRNAs) are small 18-22 RNA molecules that function as posttranscriptional regulators. They abundantly present within extracellular vesicles (EVs), intercellular communication can be found in bodily fluids have key functions pathological physiological pathways. Recently, EVs gained much interest because of their diagnostic therapeutic potential. Using NanoString...
MicroRNAs (miRNAs or miRs) are small molecules known to be involved in post-transcriptional gene expression. Many of them have been shown influence risk for various diseases. Recent studies suggest that lower expression miR-204, a coding miRNA-204, is correlated with shorter survival patients acute myeloid leukaemia (AML). This observation prompted us analyse the effect two polymorphisms miR-204 gene, one upstream flanking region (rs718447 A > G) and other inside itself (rs112062096 G), both...
A genetic polymorphism, rs2204985, has been reported to be associated with the diversity of T-cell antigen receptor repertoire and TREC levels, reflecting function thymus. As thymus can assumed an important factor regulating outcome stem cell transplantation (SCT), it was great interest that rs2204985 showed a association disease-free overall survival in German SCT donor cohort. Tools predict more accurately would help risk assessment patient safety.
Abstract Natural killer (NK) cells recognize and may kill malignant via their cell surface receptors. Killer immunoglobulin-like receptor (KIR) genotypes of donors have been reported to adjust the risk relapse after allogeneic stem transplantation (HSCT), particularly in patients with acute myeloid leukemia. To test whether non-KIR NK receptors a similar effect, we screened 1,638 genetic polymorphisms 21 genes for associations graft-versus-host disease (GVHD) HSCT 1,491 (from Finland, UK,...
Telomere dysfunction is a notable event observed in many cancers contributing to their genomic instability. A major factor controlling telomere stability the human telomerase reverse transcriptase catalytic subunit (hTERT). shortening has been multiple myeloma (MM), plasma cell malignancy with complex and heterogeneous genetic background. In present study, we aimed analyse length hTERT variants as potential markers of risk survival 251 MM patients. We found that was significantly shorter...
Abstract Multiple myeloma (MM) is a heterogeneous bone marrow cancer characterized by proliferation of malignant plasma cells in the marrow. One its major symptoms are hypercalcaemia and lesions, which may result pathologic fractures. Receptor activator for nuclear factor κB (RANK) ligand, RANKL, part an activation pathway osteoclasts thus responsible resorption. Furthermore, RANKL expression increased multiple myeloma. In present study, we investigated role single nucleotide polymorphisms...
Transplantation of hematopoietic stem cells (HSCT) is a procedure commonly used in treatment various haematological disorders which associated with significantly improved survival rates. However, one its drawbacks the possibility development post-transplant complications, including acute and chronic graft-versus-host disease (GvHD) or CMV infection. Various studies suggested that NK their receptors may affect transplant outcome. In present study, patients donors were found to differ...
Background/Aim: Vascular endothelial growth factor (VEGF) and basic fibroblast (bFGF) play an important role in the initiation of angiogenesis. We aimed to assess whether polymorphisms within genes coding for these angiogenic activators (VEGF (rs3025039;C>T) bFGF (rs308395;G>C)) contribute susceptibility and/or progression multiple myeloma patients (MM) chemotherapy. Patients Methods: One hundred thirty-two with MM 122 controls were genotyped VEGF alleles by PCR-RFLP technique....