A5101899959- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Bacterial Infections and Vaccines
- RNA regulation and disease
- Pediatric Pain Management Techniques
- RNA Research and Splicing
- Opportunistic and Delay-Tolerant Networks
- Advanced Image Fusion Techniques
- Pharmacological Effects of Natural Compounds
- Spectroscopy and Chemometric Analyses
- Pain Management and Placebo Effect
- Advanced Decision-Making Techniques
- Animal Virus Infections Studies
- Cancer Cells and Metastasis
- Human Mobility and Location-Based Analysis
- Amoebic Infections and Treatments
- Caching and Content Delivery
- Whipple's Disease and Interleukins
- Influenza Virus Research Studies
- Mesenchymal stem cell research
- Perfectionism, Procrastination, Anxiety Studies
- Advanced Sensor and Control Systems
Xidian University
2025
Waseda University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2021
Palo Alto University
2018
Stanford University
2018
Institute of Medical Biology
2018
Viterbo University
2015
University of Southern California
2015
Second Affiliated Hospital of Kunming Medical College
2010-2011
Kunming Medical University
2010-2011
Enterovirus 71 (EV71) is a major cause of hand, foot, and mouth disease in children may be fatal. A vaccine against EV71 needed.We conducted randomized, double-blind, placebo-controlled phase 3 trial involving healthy 6 to months age Guangxi Zhuang Autonomous Region, China. Two doses an inactivated or placebo were administered intramuscularly, with 4-week interval between doses, monitored for up 11 months. The primary end point was protection caused by EV71.A total 12,000 randomly assigned...
The COVID-19 has emerged as an epidemic, causing severe pneumonia with a high infection rate globally. To better understand the pathogenesis caused by SARS-CoV-2, we developed rhesus macaque model to mimic natural via nasal route, resulting in SARS-CoV-2 virus shedding nose and stool up 27 days. Importantly, observed pathological progression of marked interstitial infected animals on 5–7 dpi, dissemination widely occurring lower respiratory tract lymph nodes, viral RNA was consistently...
Coxsackievirus A16 (CA16) is a member of the Picornaviridae family and causes mild self-limiting hand, foot, mouth disease (HFMD) in infants young children. CA16 infection can also progress to central nervous system (CNS) complications; however, underlying mechanism by which penetrates blood-brain barrier (BBB) then CNS damage remains unclear. This study aimed explore neurotropic tropism establishing an vitro BBB model with vivo rhesus monkey infant model. The results showed that induced...
Coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), leads to a series of clinical symptoms and pulmonary inflammatory reactions via unknown pathologic mechanisms related the viral infection process in tracheal or bronchial epithelial cells. Investigation this human cell line (16HBE) suggests that SARS-CoV-2 can enter these cells through interaction between its membrane-localized S protein with angiotensin-converting enzyme 2 molecule on host...
SARS-CoV-2 caused the COVID-19 pandemic that lasted for more than a year. Globally, there is an urgent need to use safe and effective vaccines immunization achieve comprehensive protection against infection. Focusing on developing rapid vaccine platform with significant immunogenicity as well broad high efficiency, we designed spike protein receptor-binding domain (RBD) displayed self-assembled ferritin nanoparticles. In 293i cells eukaryotic expression system, this candidate was prepared...
To investigate the long-term effects on immunity of an inactivated enterovirus 71 (EV71) vaccine and its protective efficacy. A sub-cohort 1,100 volunteers from Guangxi Province in China was eligible for enrolment randomly administered either EV71 or a placebo days 0 28 phase III clinical trial then observed following 2 years with approval by independent ethics committee Zhuang Autonomous Region, China. Serum samples 350 participants who provided full series blood (at all sampling points)...
Enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16) remain the predominant etiological agents of hand, foot, mouth disease (HFMD). The clinical manifestations caused by two viruses are obviously different. CV-A16 usually triggers a repeated infection, airway epithelial integrity is often potential causative factor respiratory infections. Our previous studies have demonstrated that there were some differentially expressed miRNAs involved in regulation adhesion function barrier EV-A71 In...
Routing is a challenging issue in mobile social networks (MSNs) because of time-varying links and intermittent connectivity. In order to enable nodes make right decisions while forwarding messages, exploiting relationship has become an important method for designing efficient routing protocols MSNs. this paper, we first use the temporal evolution graph model accurately capture dynamic topology MSN. Based on model, introduce metric detecting quality human from contact history records....
Enterovirus 71 (EV71) can cause serious nervous system lesions but to date the pathogenesis has been unclear. Our results show that EV71 proliferates in neural cells and leads cell lesions. The study of pathology infection neonatal rat brains shows invasive ability vivo may depend on many unknown factors.
Images taken in low-light conditions often have the problem of poor visibility. Besides inadequate lightings, different types image quality degradation, such as a large amount noise and color loss due to limited cameras camera ISO setting, cause low captured image. However, directly amplifying darkness lowlight will inescapably bring into pollution Therefore, task enhancement needs kindle dark regions remove degradation. To achieve this task, our work builds Retinex theorybased neural...
Blind separation of source signals usually relies either on the condition statistically independence or involving their higher-order cumulants. The model two channels signal is considered. A criterion based correlation functions proposed. It proved that can be separated, using only noncorrelation. An algorithm derived, which involves solution to quadric nonlinear equations.
Background: Enterovirus 71 (EV71) and coxsackievirus A16 are the main causative agents of hand, foot mouth disease (HFMD), but their pathogenicity has been shown to exhibit wide diversity.Methods: To illuminate diverse EV71 CA16, microRNA (miRNA) profiles human diploid cells infected with these two viruses were analyzed using an eukaryotic miRNA expression array.Results: Unlike EV71, directly stimulating effective immune response, CA16 infection failed effectively activate cytokines or...