Introduction. Sarcopenia of the spinal stabilizing muscles is one components age-related sarcopenia and often associated with chronic back pain (CBP), including osteoarthritis (OA). The age dynamics paraspinal muscle mass in OA not sufficiently studied to date, although it key developing rehabilitation prevention strategies. aim study identify individuals by assessing analyzing its relationship degenerative changes different groups using magnetic resonance imaging (MRI). Materials methods....

Introduction: Degenerative disc disease (DDD) is a major cause of lower back pain (LBP). Key pathological processes intervertebral (IVD) degeneration include extracellular matrix (ECM) degradation (including aggrecan loss), cartilage dehydration, and ingrowth blood vessels nerve fibers. Neurotrophins neuropeptides, such as growth factor (NGF) substance P (SP), play an essential role in LBP pathogenesis, neoinnervation, inflammation, the maintenance chronic pain. Materials Methods: Thirty-six...

ABSTRACT Back pain (BP) due to degenerative spinal injury is a severe, often disabling disease and it tends decrease age of onset. The cellular molecular basis the disc adjacent structures degradation remains in focus pathophysiologists pathomorphologists close attention. aim study was determine expression level proinflammatory cytokines (IL-1β, IL-6, IL-17) angiogenesis markers (VEGF-A CD31) intervertebral (IVD) tissue, their association between each other degeneration young people with...

Introduction. One of the distinguishing features systemic vasculitis is their manifestation under guise a lesion one or another organ system, which often multi-organ in nature with signs inflammation. The latter interpreted primarily as part an infectious paraneoplastic process, causes delay diagnosis. aim study was to present diversity clinical picture associated antineutrophil cytoplasmic antibodies (ANCA), speed and large volume diagnostic measures effective cooperation therapeutic...

Back pain (BP), associated with the degenerative disc disease (DDD), poses a heavy social and economic burden due to early disability indications surgery, emerging in young adults. Pathophysiological basis of premature intervertebral (IVD) degeneration is being actively studied. The study was aimed define profiles inflammatory cytokines DDD, as well their relationship structural spine diseases. molecular genetic analysis mRNA gene abundance patients BP herniated IVD after discectomy healthy...

Back pain (BP) is a major public health problem worldwide with high prevalence and disability. In most cases are associated degenerative spinal disease (degenerative disc disease, DDD), myofascial syndrome, facet joint spondylosis, scoliotic deformation, sacroilial dysfunction, lumbar stenosis other causes. The article describes the basics of doctor’s approach to diagnosis back pain, main strategies patients routing. algorithm proposed here includes detection dangerous conditions,...

Back pain in young people (14–35 years old) may have causes rooted adolescence or even earlier childhood. Diagnosis this case can present considerable difficulties for a therapist and general practitioner, since “nonspecific back pain” hide pathological conditions inherent The degree of compensation scoliosis, hereditary abnormalities the development spine, severity early degenerative processes, metabolic diseases skeleton that were not identified during school determine non-standard scope...

Back pain is a common reason for seeking primary care from older and younger people. Early spinal imaging by therapist indicated to eliminate potentially dangerous causes of pain. Independent magnetic resonance or computed tomography examination at the patient’s initiative in absence “red flags” back most cases does not come close identifying obvious cause syndrome, it creates preconditions formation an exaggerated picture disease patient himself, driving him into “trap” chronic Attention...

Osteoporotic vertebral fractures (OVF) are a severe complication of osteoporosis associated adverse outcomes, acute and chronic pain syndrome. If (deformities) detected, is diagnosed regardless bone mineral density the 10-year absolute fracture risk scale Fracture Risk Assessment Tool, but subject to exclusion other metabolic osteopathies. The article presents differential diagnosis OVF with osteopathies such as osteomalacia, tumors or metastatic lesions spine, Paget»s disease, myeloma,...

An open-labeled randomized study of the efficacy and safety Piascledine-300 in combination with nonsteroidal anti-inflammatory drugs (NSAIDs) versus latter was conducted 2 matched groups patients lower back pain associated spondylarthrosis. During combined therapy using Piascledine, there a reduction syndrome particularly longer administration drug. The use Piascledine spondylarthrosis showed its clinical 89,2% patients: indices lumbago substantially reduced spinal function improved, which...

Pain syndrome in the shoulder occurs every 5th adult and is 2nd most frequent reason for seeking primary medical care among all musculoskeletal disorders. Group of local causes pain area. The starting point differential search patient’s age. For persons younger than 40, common are joint instability (dislocations / subluxations), as well mild damage rotator cuff muscles due to injury. Patients older 40 have an increased risk severe chronic disorders above-mentioned muscles, adhesive...

Connective tissue dysplasia (CTD) represents special ontogenetic abnormality which is a complex problem of contemporary medicine. The principles differential diagnosis various forms CTD are considered. A clinical estimation and therapy approaches discussed with focus on hypermobility syndrome as one undifferentiated form CTD.

To date, cardiovascular diseases occupy the first place in structure of total morbidity and mortality many countries. In 2013 Russian Federation from disease died 1 million 799 thousand people, bottom 529.8 coronary heart disease, primary role belongs to myocardial infarction its complications. Currently, "gold standard" for diagnosis including infarction, remains angiography; main objectives angiography are assess features anatomy, determination possibility endovascular treatment...

The main approaches to diagnosis and treatment of pain in the back elderly are presented. place is given varieties of mechanical pain. Clinical features non-traumatic compression vertebrae, ostheoporosis fractures are described. problem differential infectious, neoplastic, metabolic damage spine discussed. therapeutic approaches therapy acute mechanical identified.

В статье отражены новейшие аспекты диагностики и лечения важнейших разновидностей дорсопатий - воспалительных спондилопатий спондилеза.

Spondyloarthritis (SpA) has extremely high social importance due to patient’s risk of early disability and a persistent decline in the quality life. The last decade brought important knowledge on its genetic mechanisms pathophysiological aspects, as well diagnosis treatment. Axial spondyloarthritis (axSpA) is characterized by pathological tissue response immune mechanical triggers, predominant lesion axial skeleton (spine, sacroiliac joints). It divided into ankylosing spondylitis (AS)...

This article addresses issues of classification, and objective assessment the pain, clinical variants pain are described, modern methods therapy presented.

<h3>Background</h3> Spine osteoarthritisis one of the leading places in structure Rheumatic Diseases. Until recently, degeneration intervertebral disc (IVD), reflected reduction number cell and components matrix (proteoglycans, collagen), associated with aging. There is evidence for development accelerated IVD, which can result long-term microtraumatic actions to spinal motion segment (SMS). Detection a degenerative changes IVD adolescence early young age using magnetic resonance imaging as...