A5020491630- Pulmonary Hypertension Research and Treatments
- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Multiple and Secondary Primary Cancers
- Medical and Biological Sciences
- Renal cell carcinoma treatment
- Myofascial pain diagnosis and treatment
- Psoriasis: Treatment and Pathogenesis
- Connective Tissue Growth Factor Research
- Urological Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Inflammatory mediators and NSAID effects
- Bone health and treatments
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Sarcoidosis and Beryllium Toxicity Research
- Sleep and Wakefulness Research
- Advanced Radiotherapy Techniques
- Cancer, Hypoxia, and Metabolism
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Pelvic and Acetabular Injuries
- Lung Cancer Diagnosis and Treatment
Pirogov Russian National Research Medical University
2014-2025
City Clinical Hospital
2021-2025
Ministry of Health of the Russian Federation
2014-2025
Kuban State Agrarian University
2022
University Hospital Schleswig-Holstein
2019
University of Lübeck
2019
Federal Agency for Health and Social Development
2014
National Medical and Surgical Center named after N.I. Pirogov
2013
Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive cells remains a holy grail autoimmune therapy, but disease-associated receptors (TCRs) cognate antigenic epitopes remained elusive. A TRBV9-containing CD8+ TCR motif was recently associated with the pathogenesis ankylosing spondylitis, psoriatic arthritis acute anterior uveitis, HLA-B*27-presented were identified. Following...
The Russian Society of Cardiology (RSC) With the participation of: Association Cardiovascular Surgeons, Eurasian (EAC), Medical on Arterial Hypertension (RMSAH), Respiratory (RRS), Anesthesiologists and Intensive Care Specialists, Radiologists (RSRR), Rheumatologists Russia. Endorsed by Research Practical Council Ministry Health Federation (12.09.2024).
The aim – to evaluate the clinical effectiveness, safety, pharmacokinetics, pharmacodynamics, and immunogenicity of seniprutug (BCD-180) in patients with radiographic active axial spondyloarthritis (r-axSpA, or ankylosing spondylitis). Subjects methods . 260 r-axSpA inadequate response nonsteroidal anti-inflammatory drugs (NSAIDs) were randomized into three groups: at doses 5 mg/kg 7 mg/kg, placebo. BCD-180 was administered on weeks 0–12–36. Patients placebo group switched a dose week 24...
Metabolic syndrome (MS) is a complex of metabolic disorders, including insulin resistance, abdominal obesity, diabetes mellitus, hyperuricemia and arterial hypertension. According to the World Health Organization, number people with obesity worldwide steadily increasing, taking on characteristics “pandemic”. Against this backdrop, diseases pathogenetically linked MS, such as osteoarthritis (OA), are gaining particular significance. Modern biochemical molecular-genetic research has provided...
Pulmonary Hypertension (PH) is a hemodynamic and pathophysiological condition characterized by an increase in mean pulmonary artery (PA) pressure at least 20 mm Hg rest, measured during right heart catheterization. One of the fastest most accessible screening non-invasive diagnostic methods for assessing likelihood this echocardiography, which performed according to standard transthoracic echocardiography protocol, focusing on visualizing describing certain parameters that characterize...
Introduction. Sarcopenia of the spinal stabilizing muscles is one components age-related sarcopenia and often associated with chronic back pain (CBP), including osteoarthritis (OA). The age dynamics paraspinal muscle mass in OA not sufficiently studied to date, although it key developing rehabilitation prevention strategies. aim study identify individuals by assessing analyzing its relationship degenerative changes different groups using magnetic resonance imaging (MRI). Materials methods....
The article presents a description of 73-year-old patient with rheumatoid arthritis, complicated by the development neurological deficit in form tetraparesis. Magnetic resonance imaging cervical spine revealed destruction C2 odontoid process its replacement pannus, atlantoaxial subluxation, compression proximal segments spinal cord, and fracture C5.
Background: Acute heart failure (AHF) is one of the leading causes admissions to emergency department (ED). There a need develop an easy-to-use score that can be used in ED risk-stratify patients with AHF and hospitalization decisions regarding cardiac wards or intensive care units (ICUs). Methods: A retrospective observational study was conducted at city hospital. The data from presentation were collected. combined primary endpoint included death any cause during transfer unit (ICU) for...
Introduction. Tick-borne borreliosis is characterized by polysystemic manifestations with a tendency to become chronic. If no antibiotic therapy provided, the course of comorbidities (cardiovascular, cerebral and articular) significantly worsens in elderly patients. Aim. To present data on Lyme associated damage manifested as developing severe neuroborreliosis, monoarthritis, extensive acrodermatitis, carditis based clinical case an female patient hospitalized pattern acute myocardial...
Introduction: Degenerative disc disease (DDD) is a major cause of lower back pain (LBP). Key pathological processes intervertebral (IVD) degeneration include extracellular matrix (ECM) degradation (including aggrecan loss), cartilage dehydration, and ingrowth blood vessels nerve fibers. Neurotrophins neuropeptides, such as growth factor (NGF) substance P (SP), play an essential role in LBP pathogenesis, neoinnervation, inflammation, the maintenance chronic pain. Materials Methods: Thirty-six...
Abstract. Introduction. Tick-borne borreliosis is characterized by polysystemic manifestations with a tendency to become chronic. If no antibiotic therapy provided, the course of comorbidities (cardiovascular, cerebral and articular) significantly worsens in elderly patients. Aim. To present data on Lyme associated damage manifested as developing severe neuroborreliosis, monoarthritis, extensive acrodermatitis, carditis based clinical case an female patient hospitalized pattern acute...
Sleep disorders are becoming increasingly important due to the high comorbidity with other diseases and a significant impact on patient's quality of life. Insomnia is most common sleep disorder both in general population patients multimorbid pathology. Its prevalence 6-15%, while somatic it increases up 20-40% can reach 90% comorbid mental disorders. Another problem development drug-induced insomnia. has negative prognosis diseases, including an increased risk death, more severe disease,...
The medical and social significance of systemic sclerosis (SSc) is high. progressive disease has a significant impact on the functional status, work participation leads to early disability in patients working age. article presents data prevalence with SSc comparison other rheumatic diseases, frequency separation from transitions due problems connected SSc, socio-economic burden different countries. specifies components which affect ability work, main approaches quantify indicators ability,...
The conclusion of the Expert Council presents results discussing diagnosis and therapy interstitial lung diseases in systemic scleroderma. reason for this discussion was emergence new data on use nintedanib category patients.
Systemic vasculitides (SV) are a heterogeneous group of acute and chronic diseases, the most important pathomorphological sign which is inflammation necrosis vascular wall. The basis for classification SV their etiology pathogenesis, type affected vessels pattern inflammation, predominant organ involvements, clinical manifestations, genetic predisposition, demographic characteristics. To diagnose vasculitis difficult task due to broad spectrum its manifestations that depend on size vessels,...
Pulmonary hypertension and right heart dysfunction often complicate the course of chronic failure. At same time, addition these pathological conditions significantly increases frequency hospitalizations worsens survival prognosis. That is why assessment unfavorable outcome’s risk in group such patients extremely important. This problem draws an interest for a more detailed study, considering fact that most convenient, accessible minimally invasive prognosis marker has still being searched...
Pulmonary hypertension is a serious cardiovascular pathology, often complicating the course of heart failure (HF). Excessive pulmonary artery pressure increases right ventricular afterload and progressively leads to dysfunction, which associated with adverse outcomes regardless left ejection fraction. In this regard, more attention should be paid determining condition. Currently, in order assess function patients HF, (RV)-pulmonary arterial (PA) coupling, increasingly being used. The...
Objective : to carry out a complex assessment of life quality (LQ) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) according SF-36 questionnaire. Materials and methods. The study included 20 who underwent in-patient examination treatment City Clinical Hospital № 1 n.a. N.I. Pirogov (Moscow Healthcare Department) confirm the diagnosis CTEPH for selection drug therapy. All completed standardized possible association various parameters this questionnaire both clinical...
The problem of fibrosing interstitial lung diseases (ILDs) unites specialists from different areas: pulmonologists, radiologists, therapists, rheumatologists, occupational doctors and others. Actual achievements in studying ILDs which are connected with development immunology molecular biological methods for the determination biomarkers, new principles image-diagnostics pathology, search therapeutic “targets”, dictate necessity integration knowledge by areas medicine improvement...
The problem of pain today remains one the fundamental issues medical care. It is known that leading cause treatment to doctor. Among syndromes, a special place belongs complex regional syndromes. They are distinguished by multidisciplinary problem, presence explicit nature pain, difficulty diagnosis and treatment. article presents modern data on
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used pain relievers. However, their use often threatens with serious undesirable effects, associated mainly damage to cardiovascular system (CVS), gastrointestinal tract, kidneys and liver. Contraindications NSAIDs prescription clearly regulated, algorithms for personalized appointment determined taking into account risk factors adverse events. The severity of side effects is due selectivity cyclooxygenase-2 (COX-2), as well...
Cardiac surgery is the only radical method of treatment valvular defects (congenital or acquired): valve preservation procedures prosthetics operations. 250 000 – 280 prostheses are implanted every year worldwide, while number prosthetic valves operation increases by an average 5–7 % per (biological 8–11 %, mechanical 3–5 %). Selection biological types prosthesis, its location, presence associated risk factors for embolic events, such as atrial fibrillation, previous embolism, left...