A5075522433- Neurological Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Neurological Disease Mechanisms and Treatments
- Healthcare Systems and Public Health
- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Pharmaceutical Practices and Patient Outcomes
- Sleep and Wakefulness Research
- Long-Term Effects of COVID-19
- Schizophrenia research and treatment
- Neurological disorders and treatments
- Sleep and related disorders
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Pain Mechanisms and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Anesthesia and Sedative Agents
- Intracerebral and Subarachnoid Hemorrhage Research
- Heart Rate Variability and Autonomic Control
- Intensive Care Unit Cognitive Disorders
Sechenov University
2017-2024
Russian Academy of Sciences
2020-2021
Sleep disorders are becoming increasingly important due to the high comorbidity with other diseases and a significant impact on patient's quality of life. Insomnia is most common sleep disorder both in general population patients multimorbid pathology. Its prevalence 6-15%, while somatic it increases up 20-40% can reach 90% comorbid mental disorders. Another problem development drug-induced insomnia. has negative prognosis diseases, including an increased risk death, more severe disease,...
The neurological manifestations of the novel coronavirus COVID-19 infection caused by SARS-CoV-2 are extremely diverse. At same time, there is currently very little data on complications COVID-19. There more and publications presence a complication, such as cognitive impairment (CI). latter analyzed in patients with during their hospital stay later on. paper discusses possible mechanisms, including hyperinflammatory state (cytokine storm), coagulopathy, neurotropic effect virus, which may...
Arterial hypertension (AH) is the major modifiable risk factor for cognitive impairment (CI), including dementia, CI in cerebrovascular and neurodegenerative diseases, Alzheimers disease. By 2050, number of people with dementia will approximately 3 times increase due to aging population limited opportunities drug prevention treatment severe CI. In connection above, it seems necessary create an expert consensus, which would summarize evidence-based medicine data available date on effect...
Insomnia is frequently detected in patients with arterial hypertension (AH): from 19% to 47.9% of all cases according epidemiological studies. On the other hand, frequency insomnia ranges 21.4% 50.2%, whereas without insomnia, 11.0% 41.8%. In single studies which underwent ambulatory blood pressure monitoring (ABPM), these showed higher nocturnal levels. Recent data suggests that also a risk factor for hypertension. Among pathogenetic mechanisms explaining relationship between and an...
To evaluate the efficacy and safety of prolonged sequential therapy with mexidol in acute early recovery stages hemispheric ischemic stroke (IS) across age groups according to World Health Organization classification.The study is an additional analysis among patients participated randomized double blind multicenter placebo-controlled, parallel trial EPICA. All subjects (62 men 88 women) were subdivided into groups: younger than 60 years, 60-65 76-90 years. Additionally, all participants...
Aim. To evaluate the presence and severity of complaints (headache, dizziness, memory loss, concentration attention, sleep disturbances, decreased mood, increased anxiety), state cognitive functions, emotional status quality night in treatment-naïve middle-aged patients with mild to moderate EAH compared healthy volunteers same age. Materials methods. 103 aged 40-59 years at enrollment, who met inclusion/exclusion criteria provided written informed consent (46 men, mean age 53.6±0.8 years)...
We discuss in this article problems of prognostic significance 24‑hour arterial pressure variability (24hAPV), as well the role 24hAPV development and progression various target organs damage by hypertension. also present literature data on impact regimens antihypertensive therapy 24hAPV, ability fixed-dose perindopril/amlodipine to lower 24‑hAPV.
Hypertension is one of the main modifiable risk factors for cognitive impairment (CI) and dementia in middle-aged elderly patients. CI occurs patients with hypertension even its short duration manifested by controlling dysfunctiona speed decline. The paper presents results a neuropsychological examination 50 middle age (47.54±5.2 years) short-term (2.6±5.5 uncomplicated hypertension. Stable blood pressure normalization during antihypertensive therapy improves function prevents progression...
1 ФГАОУ ВО «Первый Московский государственный медицинский университет им.И. М. Сеченова» Минздрава России (Сеченовский Университет), Москва 2 ФГБОУ «Московский медико-стоматологический им.А
One of the reasons for development or worsening cognitive impairment (CI) may be use a number drugs: non-steroidal anti-inflammatory drugs, antiarrhythmics, antidepressants, glucocorticosteroids, antitumor drugs and others. The negative effect on functions is realized due to many pathophysiological mechanisms: disruption hormonal regulation, decreased neuronal excitability, increased activity gamma-aminobutyric acid receptors, cerebral circulation, atrophic changes in brain; mechanisms have...
The disease caused by the SARS-CoV-2 virus is multi-organ and involves almost all organs systems. Myalgias arthralgias and, in particular, back pain are common symptoms of COVID-19 can be observed both at onset postcovid period. causes muscle joint damage include systemic inflammation direct viral injury. Traditionally, musculoskeletal treated with non-steroidal anti-inflammatory drugs. However, using this drug class patients requires caution due to presence comorbid diseases possible...
Diffusion tensor magnetic resonance imaging (DT-MRI) is the only noninvasive technique that makes it possible to study white matter microstructure in vivo and quantify images obtained. Objective : middle-aged treatment-naХ ve patients with uncomplicated grade 1–2 essential hypertension (EH), by using DT-MRI. Patients methods . The investigation enrolled 82 people aged 40–59 years (41 EH 41 healthy individuals (a control group)). Twenty-four blood pressure monitoring brain MRI were performed...
To study cognitive functions, anxiety and depression levels, 24-hour blood pressure (BP) profile, cerebral flow (CBF) perfusion in treatment-naive middle-aged patients with uncomplicated essential arterial hypertension (EAH) depending on the white matter hyperintensities (WMH) burden.Forty-one hypertensive (mean age 46.2±4.6 years) 41 healthy volunteers 50.3±6.7 were enrolled to study. All subjects underwent brain MRI (MAGNETOM Skyra 3.0T, T1, T2 FSE, FLAIR, T1 MPRAGE, ASL), Montreal...
Many classes of medications, such as antipsychotics, anticonvulsants, anticholinergics, and other commonly prescribed drugs, can cause cognitive impairment (CI). The negative effect drugs on functions is due to the following pathophysiological mechanisms: a reduction in neuronal excitability, an increase gamma-aminobutyric acid activity, decreases enzyme number receptors, cerebral perfusion, well brain atrophy; moreover, mechanisms have not been fully studied. An important role development...
Management of patients with cognitive impairment is one the most relevant and important problems neurology. It especially to identify at early (pre-dementia) stages, when appropriate medical measures are implemented, progression decline can be slowed down or stopped. Near-moderate (NMCD) elderly senile ages may a predictor for development clinically significant up dementia. In Western works, NMCD associated subjective decline, but it would more legitimate distinguish form (a stage) mild...
Some patients are more likely to have drug-induced diseases due a number of risk factors, such as older age. The aim the study was analyse effect age on pharmacokinetics and pharmacodynamics medicines developing diseases. analysis scientific literature demonstrated that changes in functions body organs systems caused by natural aging processes may potentially affect increase adverse drug reactions. For instance, people decreased cardiac output both at rest during exercise, weight loss, loss...
Atrial fibrillation (AF) is the main cause of cardioembolic ischemic stroke (IS), it occurs in 25–35% patients with IS, and its presence increases risk recurrent compared sinus rhythm. The method preventing IS AF administration oral anticoagulants (OACs); non-valvular AF, direct OACs (DOACs) have an advantage. Meta-analysis randomized clinical trials showed a 19% greater reduction systemic embolism DOACs group to warfarin (p<0.0001), including 51% hemorrhagic (HS) (p<0.0001). In...
The article describes the definition of dementia, its diagnostic criteria, classification. Differences in pathogenesis and clinical manifestations different types dementia are considered. issues interrelation arterial hypertension risk development cognitive disorders old very people discussed detail. Data on effect antihypertensive drugs groups state functions presented. evidence base dihydropyridine calcium antagonist amlodipine thiazide-like diuretic indapamide-retard is with respect to...
Arterial hypertension (HT) is one of the main recognized risk factors for development cognitive impairment and dementia. The results most studies indicate that presence HT in elderly senile people associated with a decrease functions an increased dementia this age group, although some have identified so-called "U-shaped curve". state middle-aged patients has been studied to much lesser extent, but it established middle deterioration elderly. In hypertensive patients, affected all domens,...
There is a growing interest to the problem of drug-induced epileptic seizures (ES) due their relatively high prevalence, poor prognosis, large number different drugs associated with development ES, and low awareness among general practitioners. Drug-induced ES are most often use antidepressants, antipsychotics, antiepileptic (overdose or as result discontinuation), antibiotics, immunosuppressants immunomodulators, antitumor agents, analgesics, central nervous system stimulators, anesthetics...
The review discusses the problem of overweight, obesity and metabolic syndrome their activating effect on sympathetic nervous system increase in blood pressure. Current epidemiological data prevalence trends occurrence recent decades are presented, indicating high significance these disorders modern health care important role development overall disease burden. In accordance with clinical guidelines, types described a special focus its abdominal type, as factor that increases cardiovascular...
Restless legs syndrome (RLS) is a sensorimotor disorder characterized by complaints of strong desire to move during periods rest or inactivity, which relieved movement (most pronounced in the evening at night). Multiple studies have reported drug-induced RLS caused antipsychotics, antidepressants and antiepileptic medications. Risk factors for include older age, gastrointestinal diseases, high medication dose, simultaneous use ≥2 drugs. The mechanism most often associated with effect...