A5056036798- Vitamin D Research Studies
- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diet and metabolism studies
- Vitamin C and Antioxidants Research
- Connective Tissue Growth Factor Research
- Human Health and Disease
- Inflammatory Myopathies and Dermatomyositis
- Nutritional Studies and Diet
- Dermatologic Treatments and Research
- Cardiovascular Disease and Adiposity
- Obesity and Health Practices
- Mast cells and histamine
- Menstrual Health and Disorders
Ministry of Health of the Russian Federation
2023-2024
Pirogov Russian National Research Medical University
2023-2024
First Pavlov State Medical University of St. Petersburg
2012-2013
Introduction. Systemic sclerosis (scleroderma) is an autoimmune disease that often causes inflammatory fibrosing lesions of the pulmonary interstitial tissue, referred to as lung disease. It associated with a significant reduction in survival and leading immediate cause systemic scleroderma patients’ death. Progression rate varies greatly. Since specific immunosuppressive antifibrotic treatment only justified case progressive lesions, predicting progression great practical importance. Aim: To...
The examination of residents St. Petersburg and Petrozavodsk revealed a high frequency vitamin D deficiency according to the criteria International Society Endocrinology (ENDO, 2011), normal levels sufficiency had only 16.8% north-western region Russian Federation, while insufficiency was seen in 37.5%, deficit — 45.7% patients. When reviewing results using proposed by U.S. Institute Medicine (IOM, values 25(OH)D serum were detected 49.6% insufficient 40.0% 10.4%. decrease ofvitamin...
The patients with obesity are known to suffer 25-hydroxy vitamin D (25(OH)D) deficiency, but the relationship between these two conditions remains unclear. blood 25(ON)D levels in practically healthy women were compared amount and distribution patterns of fatty tissue content plasma adipocytokines. absence or deficit was documented 61.3% included present study. They exhibited negative correlation 25(ON) body weight. characterized by waist circumference, weight, BMI, tissue. reproductive age...
The medical and social significance of systemic sclerosis (SSc) is high. progressive disease has a significant impact on the functional status, work participation leads to early disability in patients working age. article presents data prevalence with SSc comparison other rheumatic diseases, frequency separation from transitions due problems connected SSc, socio-economic burden different countries. specifies components which affect ability work, main approaches quantify indicators ability,...
Background. Some studies suggest that serum 25(OH) vitamin D level could be associated with fat mass quantity and glucose metabolism parameters. However, the data seem to contradictory. Objective. We examined interrelatoins between 25(OH)D body composition, parameters in healthy women. Design methods. 320 late reproductive age women (aged 40 52 years old, mean — 46.1 ± 4.5 years). Serum insulin levels were determined by ELISA, plasma standard biochemistry. Insulin resistance was evaluated...
Российская Федерация в силу географического расположения и экономических особенностей имеет все предпосылки для развития недостатка дефицита витамина D. Цель исследования. Оценить уровень 25(OH)D) крови у жителей Северо-Западного региона РФ изучения распространенности D его вклада здоровье. Материал методы. В исследование включено 1690 человек (1349 возрасте 18-75 лет, включая 221 беременную 120 детей/подростков 3-17 лет). Уровень 25(OH)D оценивался хемилюминесцентным методом...
In patients with systemic sclerosis (SSc), interstitial lung disease (ILD) is a factor in the decline of functional capacity up to disability and also leading cause death. Therefore, one most important tasks treatment this group not only detect involvement respiratory system, but predict likelihood its development. Objective : study possibility predicting development ILD advanced SSc. Material methods . The included 79 SSc (mean age 64.4±11.5 years; 94.9% women) from Registry myositis, Mixed...
Aim. To determine the factors that contribute to prediction of volume pulmonary lesion in patients with systemic scleroderma (SSc). Materials and methods. The analysis included SSc observed Registry Myositis, sclerosis mixed connective tissue disease (REMISSIS), who underwent high-resolution computed tomography (HRCT) lungs. For immunological characteristic, all were tested for anti-topoisomerase (anti-Scl-70), anti-centromeric (anti-CENP-B) antibodies, anticentromere antibodies...
Aim . To study the predictors of a decrease in quality life patients with Systemic Sclerosis (SSc) Russian population. Materials and methods The included 60 reliable diagnosis SSc: 58 women 2 men. average age respondents was 61 ± 12.8 years. 29 had P-limited form SSc, also diffuse form, systemic scleroderma without scleroderma. results clinical, laboratory instrumental examinations were evaluated, as well data obtained using following questionnaires: assessments Short Form-36 (SF-36),...
Objective. Recent studies suggest high prevalence of vitamin D deficiency and its association with metabolic disturbances. However, the available data regarding relationship between level, receptor gene polymorphisms components syndrome seem to be contradictory. We examined interrelations serum 25(OH)D ApaI polymorphism parameters syndrome. Results study showed that 83,4 % population had deficiency/insuffiiency level inversely correlated body weight. Correlation analysis women higher risk...