A5077299496- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Functional Brain Connectivity Studies
- Advanced NMR Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Lanthanide and Transition Metal Complexes
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Ultrasound and Hyperthermia Applications
- Genetic Neurodegenerative Diseases
- Multiple Sclerosis Research Studies
- Bone and Joint Diseases
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Amyotrophic Lateral Sclerosis Research
- Metabolomics and Mass Spectrometry Studies
- Epilepsy research and treatment
- Advanced X-ray Imaging Techniques
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Liver Disease and Transplantation
University of Bonn
2010-2019
University Hospital Bonn
2007-2019
Krankenhaus der Barmherzigen Brüder Trier
2016
Heidelberg University
2009
University Hospital Heidelberg
2009
Central Institute of Mental Health
2009
Amsterdam UMC Location Vrije Universiteit Amsterdam
2007
Goethe University Frankfurt
2002
Philips (Germany)
2000-2001
Universität Ulm
1999
Abstract Purpose To measure 1 H relaxation times of cerebral metabolites at 3 T and to investigate regional variations within the brain. Materials Methods Investigations were performed on a 3.0‐T clinical whole‐body magnetic resonance (MR) system. T2 N‐acetyl aspartate (NAA), total creatine (tCr), choline compounds (Cho) measured in six brain regions 42 healthy subjects. T1 these myo‐inositol (Ins) determined occipital white matter (WM), frontal lobe, motor cortex 10 Results values all...
PURPOSE: To evaluate the safety and feasibility of magnetic resonance (MR) imaging at 0.5 T in patients with implanted cardiac pacemakers. MATERIALS AND METHODS: Twenty-one models pacemakers 44 pacemaker electrodes were exposed to vitro MR continuous registration output temperature lead tip. Prior examination, programmed an asynchronous mode (A00, V00, or D00). Pacemakers examined before after imaging. Forty-four underwent 51 examinations under cardiologic surveillance, electrocardiography,...
Magnetic resonance (MR) diffusion measurements of the abdomen were performed in 12 healthy volunteers by using a diffusion-weighted single-shot sequence both without and with pulse triggering for different trigger delays. Pulse to diastolic heart phase led reduced motion artifacts on MR images significantly improved accuracy reproducibility apparent coefficients, or ADCs, abdominal organs. © RSNA, 2002
To investigate the impact of a higher magnetic field strength 3 Tesla (T) on detection rate cortical lesions in multiple sclerosis (MS) patients, particular using dedicated double inversion recovery (DIR) pulse sequence.Thirty-four patients with clinically isolated syndromes or definite MS were included. All underwent resonance imaging (MRI) at 1.5 T and T, including T2-weighted turbo spin echo (TSE), fluid-attenuated (FLAIR) DIR sequences. images analysed for focal categorised according to...
Various lines of research suggest that neurotrophic processes in the hippocampus are key mechanisms major depressive disorder and relevance for response to antidepressive treatment. We performed proton magnetic resonance spectroscopy (1H-MRS) at 3 T 18 unmedicated subjects with unipolar episodes 10 age- gender-matched healthy volunteers. Thirteen patients underwent a second examination after 8 wk treatment either citalopram (n=7) or nortriptyline (n=6). Of these patients, 11 MRS datasets...
To investigate the assessment of global cortical atrophy (GCA), medial temporal lobe (MTA), and white matter changes (WMCs) in patients screened at a memory clinic with 64-detector row computed tomography (CT) brain protocol, comparison reference standard, magnetic resonance (MR) imaging.The study protocol was approved by local institutional review board. Written informed consent obtained from all participants. Thirty (21 men, nine women; median age, 62 years) who presented to underwent CT...
Purpose To prospectively compare the image quality and homogeneity of magnetic resonance (MR) images obtained by using a dual-source parallel radiofrequency (RF) excitation body MR imaging system with transmission independent RF shimming single-source standard sequences for routine clinical use in patients at 3.0 T. Materials Methods After institutional review board approval informed patient consent were obtained, 3.0-T technology was used to examine 28 compared single transmission. The...
Quantitative Cardiovascular Magnetic Resonance (CMR) techniques have gained high interest in CMR research. Myocardial T2 mapping is thought to be helpful diagnosis of acute myocardial conditions associated with edema. In this study we aimed establish a technique for based on gradient-spin-echo (GraSE) imaging.
Purpose To evaluate MRI T1 and T2 mapping with calculation of extracellular volume (ECV) for diagnosis grading liver fibrosis. Materials Methods Different grades fibrosis were induced in 60 male Sprague-Dawley rats by bile duct ligation (BDL) carbon-tetrachloride (CCl4) intoxication. Portal pressure was measured invasively, whereas hepatic quantified hydroxyproline content, Sirius red staining, α smooth muscle actin staining. values, ECV assessed using quantitative techniques. Results values...
<b><i>Background:</i></b> The reduction of <i>N</i>-acetylaspartate (NAA) detected by proton MR spectroscopy (<sup>1</sup>H-MRS) represents a robust but unspecific marker for neuronal loss or dysfunction. <b><i>Objective:</i></b> To apply <sup>1</sup>H-MRS in two brain regions that reflect the characteristic spatial distribution AD. These are medial temporal lobe (MTL), which is affected early AD, and primary motor sensory cortex (central region), late disease might serve as an...
PURPOSE: To describe the radiologic findings of susceptibility changes in acute middle cerebral artery (MCA) thromboembolism detected with three-dimensional (3D) susceptibility-based perfusion magnetic resonance (MR) imaging and to compare detectability clinical value this sign those hyperdense MCA at computed tomography (CT). MATERIALS AND METHODS: Twenty-three patients (mean age, 55 years) underwent CT MR within first 6 hours after onset stroke. The presence as depicted on T2*-weighted 3D...
<b>BACKGROUND AND PURPOSE:</b> Proton MR spectroscopy (<sup>1</sup>H-MR spectroscopy) is a well-established method for the in vivo investigation of normal-appearing white matter (NAWM) patients with multiple sclerosis (MS). Metabolic changes NAWM are special interest clinically isolated syndromes (CIS) suggestive MS regarding further prognostic classifications. The purpose this study was to investigate metabolic alterations CIS use high-field <sup>1</sup>H-MR and compare results those an...
Elderly individuals with subjective memory impairment (SMI) report decline, but perform within the age-, gender-, and education- adjusted normal range on neuropsychological tests. Longitudinal studies indicate SMI as a risk factor or early sign of Alzheimer's disease (AD). There is increasing evidence from neuroimaging that at group level, subjects display AD related pathology. This study aimed to determine differences in cortical thickness between healthy control (CO) using FreeSurfer...
To determine the motor cortex degeneration in patients with amyotrophic lateral sclerosis (ALS) using proton magnetic resonance spectroscopy, and to prove that spectroscopy is suited monitor course of disease follow-up examinations.We studied 33 ALS whose conditions were diagnosed according El Escorial World Federation Neurology criteria. Nine followed up for 2 years. The control group included 20 healthy volunteers 4 multifocal neuropathy. Proton determined levels brain metabolites...
To prospectively evaluate the feasibility, image quality, and accuracy of coronary magnetic resonance (MR) angiography at 3.0 T in patients suspected having artery disease to compare these results with those MR performed 1.5 T.The study was approved by institutional review board, informed consent obtained from all patients. Eighteen (11 men, seven women; mean age, 63 years; age range, 45-76 years) who were scheduled undergo elective conventional (reference standard) included. For T, a vector...
To prospectively and intraindividually compare the effect of magnetic resonance (MR) imaging at a higher field strength (3.0 T) on contrast-to-noise ratio (CNR) different doses T1-shortening contrast agent in patients with contrast-enhancing brain lesions, 1.5-T MR as reference standard.Institutional review board approval informed consent were obtained for all patient volunteer studies. Twelve (six women, six men; mean age, 58 years; range, 29-76 years) 12 enhancing lesions (11 primary...
Background : Imbalance of glutamatergic neurotransmission has been proposed as a key mechanism underlying symptoms schizophrenia. The neuropetide N-acetylaspartylglutamate (NAAG) modulates glutamate release. NAAG provides component the proton magnetic resonance spectrum (1H-MRS) in humans. signal NAAG, however, largely overlaps with its precursor and degrading product N-acetylaspartate (NAA) that by itself does not act neurotransmission. Methods: We quantified NAA separately from 1H-MRS 20...
The need for biological markers of Alzheimer disease (AD) is constantly increasing. Proton magnetic resonance spectroscopy ((1)H-MRS) studies have provided consistent evidence a reduction the neuronal marker N-acetylaspartate (NAA) in patients with AD. Within German Competence Network on Dementia, we conducted (1)H-MRS study mild dementia and cognitive impairment (MCI) at four sites to investigate multicenter feasibility (1)H-MRS.In total, 130 (98 AD, 32 non-AD), 136 subjects MCI (70 AD...