A5038984305- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Wound Healing and Treatments
- Liver physiology and pathology
- Immunotherapy and Immune Responses
- Pluripotent Stem Cells Research
- Inflammatory mediators and NSAID effects
- Electrospun Nanofibers in Biomedical Applications
- Immune cells in cancer
- Osteoarthritis Treatment and Mechanisms
- RNA Interference and Gene Delivery
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Organ Transplantation Techniques and Outcomes
- Periodontal Regeneration and Treatments
- T-cell and B-cell Immunology
- Bone and Joint Diseases
- Mitochondrial Function and Pathology
- Multiple Myeloma Research and Treatments
- Cancer, Hypoxia, and Metabolism
Institut Jules Bordet
2015-2025
Université Libre de Bruxelles
2016-2025
Université de Montréal
2018-2025
Centre Hospitalier de l’Université de Montréal
2021-2024
Geological Survey of India
2024
Mohamed I University
2019-2021
Erasmus Hospital
2013-2017
Lebanese University
2017
Howard Hughes Medical Institute
2016
National Institutes of Health
2016
Abstract Background MicroRNAs (miRNAs) are small (19-22-nt) single-stranded noncoding RNA molecules whose deregulation of expression can contribute to human disease including the multistep processes carcinogenesis in human. Circulating miRNAs emerging biomarkers many diseases and cancers such as type 2 diabetes, pulmonary disease, colorectal cancer, gastric cancer among others; however, defining a plasma miRNA signature acute myeloblastic leukemia (AML) that could serve biomarker for...
Preparations of mesenchymal stromal cells (MSCs) are generally obtained from unfractionated tissue cells, resulting in heterogeneous cell mixtures. Several markers were proposed to enrich these but the majority defined for bone marrow (BM). Moreover, surface freshly isolated MSCs also differ those cultured addition a phenotypic variation depending on MSC source. For engineering applications, it is crucial start with well-defined population. In this study, we performed immunomagnetic...
Mesenchymal stromal cells (MSCs) possess immunomodulatory functions and have been proposed as a tool for managing or preventing graft-versus-host disease. Recently, adipose tissue (AT) Wharton's jelly (WJ) reported potential alternative MSC sources to bone marrow (BM). In this study, we investigated the capacity of MSCs derived from AT WJ modulate lymphocyte proliferation well their impact on regulatory T-cells. We also evaluated expression leukemia inhibitory factor role molecule in...
The co-infusion of mesenchymal stromal cells (MSCs) with hematopoietic stem could improve the engraftment after cord blood transplant. Adult bone marrow is major source MSCs for cell therapy. However, aspiration involves an invasive procedure and, in case a transplant, requires use third party. umbilical matrix, called Wharton's jelly (WJ), was previously shown to be valuable MSCs. process separation not standardized and needs optimized. In this study, we focused on efficiency isolation...
CD4 + CD25 FOXP3 T regulatory cells (Tregs) are a subset of the immunomodulatory cell population that can inhibit both innate and adaptive immunity by various mechanisms. In hepatic microenvironment, proliferation, plasticity, migration, function Tregs interrelated to remaining immune their secreted cytokines chemokines. normal conditions, protect liver from inflammatory auto-immune responses, while disruption this crosstalk between other may result in progression chronic diseases...
Abstract Background The proto-oncogene Src is an important non-receptor protein tyrosine kinase involved in signaling pathways that control cell adhesion, growth, migration and differentiation. It negatively regulates osteoblast activity, and, as such, its inhibition a potential means to prevent bone loss. Dasatinib new dual Src/Bcr-Abl inhibitor initially developed for the treatment of chronic myeloid leukemia. has also shown promising results preclinical studies various solid tumors....
Mesenchymal stromal cells (MSCs) can be isolated not only from bone marrow (BM) but also other tissues, including adipose tissue (AT) and umbilical cord Wharton's Jelly (WJ). Thanks to their ability differentiate into various cell types, MSC are considered attractive candidates for cell-based regenerative therapy. In degenerative clinical settings, inflammation or infection is often involved. the present work, we hypothesized that an inflammatory environment and/or Toll-like receptor (TLR)...
Human adult stem cells (hASCs) have become an attractive source for autologous cell transplantation, tissue engineering, developmental biology, and the generation of human-based alternative in vitro models. Among 3 germ layers, mesoderm is origin today's most widely used characterized hASC populations. A variety isolated nonhematopoietic mesoderm-derived populations exist, all them show important differences terms function, efficacy, differentiation potential both vivo vitro. To better...