A5009533238- Bone Tissue Engineering Materials
- biodegradable polymer synthesis and properties
- Additive Manufacturing and 3D Printing Technologies
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Silicone and Siloxane Chemistry
- Electrospun Nanofibers in Biomedical Applications
- Titanium Alloys Microstructure and Properties
- Metal and Thin Film Mechanics
- Polymer Nanocomposite Synthesis and Irradiation
- Phytase and its Applications
- Ion-surface interactions and analysis
- Pediatric Urology and Nephrology Studies
- Peptidase Inhibition and Analysis
- Polymer Surface Interaction Studies
- Laser-Ablation Synthesis of Nanoparticles
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Kidney Stones and Urolithiasis Treatments
- Silk-based biomaterials and applications
- Enzyme Production and Characterization
- Orthopaedic implants and arthroplasty
- Dendrimers and Hyperbranched Polymers
- Microplastics and Plastic Pollution
Universidad de Extremadura
2014-2023
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2014-2023
Instituto de Salud Carlos III
2016
Plasma treatment is one of the methods currently used to obtain polymeric materials with surface properties appropriate functionality for which they were designed. However, effects achieved after modification are not always long lasting and involve chemical physical changes in outermost layer. In this context, both argon oxygen plasma on polylactic acid (PLA) films deposited titanium studied determine processes occur at surface, their duration. Regarding changes, there scarcely any...
Flavonoids are small polyphenolic molecules of natural origin with antioxidant, anti-inflammatory, and antibacterial properties. Here, a bioactive surface based on the covalent immobilization flavonoids taxifolin quercitrin titanium substrates is presented, using (3-aminopropyl)triethoxysilane (APTES) as coupling agent. FTIR XPS measurements confirm grafting to surfaces. Using 2-aminoethyl diphenylborinate (DPBA, flavonoid-specific dye), modified surfaces imaged by fluorescence microscopy....
Anionic carbosilane dendrons decorated with sulfonate functions and one thiol moiety at the focal point have been used to synthesize water-soluble gold nanoparticles (AuNPs) through direct reaction of dendrons, precursor, reducing agent in water, also a place-exchange reaction. These characterized by NMR spectroscopy, TEM, thermogravimetric analysis, X-ray photoelectron spectroscopy (XPS), UV/Vis elemental zeta-potential measurements. The interacting ability anionic was investigated EPR...
Myo-inositol hexaphosphate, also called phytic acid or phytate (IP6), is a natural molecule abundant in vegetable seeds and legumes. Among other functions, IP6 inhibits bone resorption. It adsorbed on the surface of hydroxyapatite, inhibiting its dissolution decreasing progressive loss mass. We present here method to directly functionalize Ti surfaces covalently with IP6, without using cross-linker molecule, through reaction phosphate groups TiO2 layer substrates. The grafting consisted an...
Polyphenol-based coatings have several potential applications in medical devices, such as cardiovascular stents, contrast agents, drug delivery systems, or bone implants, due to the multiple bioactive functionalities of these compounds. In a previous study, we fabricated titanium surfaces functionalized with flavonoids through covalent chemistry, and observed their osteogenic, anti-inflammatory, antifibrotic properties vitro. this work, report fluorescence-based method for quantification...
The use of biopolymers like poly(lactic acid) (PLA) doped with natural and harmless active agents in industrial, medical food packaging applications is great interest due to the multitude property enhancements included. External factors, such as UV exposure, can accelerate degradation process these biomaterials cause changes structural mechanical properties or industrial devices. In this research, PLA-based composites different degrees crystallinity are fabricated using magnesium (Mg)...
We investigated a Ti6Al4V alloy modified by means of laser peening in the absence sacrificial coatings. As consequence temperature rise during focusing, melting and ablation generated an undulated surface that exhibits important increase content titanium oxides OH− ions. Human mesenchymal stem cells osteoblasts cultured on oxidized develop noticeable filopodia lamellipodia. Their paxillin-stained focal adhesions are smaller than attached to untreated exhibit marked loss colocalization with...
Abstract In the biomedical field, water contact angle is a useful gauge to follow how biomaterial surface would interact with surrounding water-like physiological environment. Ti6Al4V alloy widely used in orthopedic applications. Nevertheless, values of its reported literature show large dispersion, from 40° up 80°. However, addition expected dependence wettability on preliminary treatments, pristine suffers an important variability and lack reproducibility. The present research pays...
The aim of the present study was to report main topographical and chemical changes a failing 18-year in function retrieved acid-etching implant micro- nanoscales. A partially edentulous 45 year old rehabilitated with dental at 18 years age exhibited mobility. After careful examination, 3.25 × 13-mm press-fit retrieved. Scanning electron microscope (SEM) analysis carried out compared an unused similar characteristics. Moreover, X-ray photoelectron spectroscopy (XPS) used surface composition...
The use of active components in biomaterials improves the properties existing ones and makes it possible to obtain new devices with antibacterial that prevent infections after implantation, thus guaranteeing success implant. In this work, cetyltrimethylammonium bromide (CTAB) magnesium particles were incorporated into polylactic acid (PLA) films assess extent which progressive aging surfaces resists bacterial colonization processes. For purpose, films’ surface was characterized by contact...
Polylactic acid (PLA) is a good candidate for the manufacture of polymeric biodegradable biomaterials. The inclusion metallic particles and surfactants solves its mechanical limitations improves wettability, respectively. In this work, cetyltrimethylammonium bromide (CTAB) magnesium have been incorporated into PLA films to evaluate changes produced in matrix cast on glass silicone substrates. For purpose, surface has characterized by means contact angle measurements ToF-SIMS. Depth profiles...
Adpsortion of protein layers on biomaterials plays an important role in the interactions between implants and bio-environment. In this context, human serum albumin (HSA) have been deposited modified Ti6Al4V surfaces at different ultraviolet (UV-C) irradiation times to observe possible changes adsorbed layer. Protein adsorption was done from solutions concentraions lower than concentration, follow surface modifications beginning adhesion process. For purpose, protein-coated samples has...
Materials used for the manufacture of implants may suffer alterations in their surface properties as a result continuous contact with physiological fluids. Moreover, biodegradable and bioabsorbable materials, such polylactic acid (PLA), these changes be more accentuated, biological response affected by presence proteins, enzymes or other compounds an oxidizing character. This research proposes to study degradation PLA close-to-reality environment supplementing buffer m-SBF concentrations...
The use of biopolymers such as poly(lactic acid) (PLA) doped with natural and harmless active agents in industrial, medical food packaging applications is great interest due to the multitude property enhancements included. Some external factors, exposure UV radiation, can accelerate degradation process these biomaterials cause changes structural mechanical properties or industrial devices. In this research, PLA-based composites different degrees crystallinity are fabricated using magnesium...