A5101525285- Protease and Inhibitor Mechanisms
- Cardiovascular Function and Risk Factors
- Peptidase Inhibition and Analysis
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Cell Adhesion Molecules Research
- Neuropeptides and Animal Physiology
- Angiogenesis and VEGF in Cancer
- Nutrition and Health in Aging
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Hormonal Regulation and Hypertension
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Cerebrovascular and Carotid Artery Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Ischemia and Reperfusion
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Disease Prevention
- Adipose Tissue and Metabolism
- Cardiac Fibrosis and Remodeling
- Muscle Physiology and Disorders
- S100 Proteins and Annexins
- Blood Pressure and Hypertension Studies
- Antioxidant Activity and Oxidative Stress
Yanbian University Hospital
2016-2025
Nagoya University
2015-2025
Yanbian University
2005-2025
Tianjin Third Central Hospital
2024-2025
Tianjin Medical University
2024-2025
Nankai University
2024-2025
First Affiliated Hospital of Chengdu Medical College
2025
Chengdu Medical College
2025
Kyung Hee University
2010-2024
Tianjin International Joint Academy of Biomedicine
2024
During angiogenesis, microvascular endothelial cells (ECs) secrete proteinases that permit penetration of the vascular basement membrane as well interstitial extracellular matrix. This study tested hypothesis cathepsin S (Cat S) contributes to angiogenesis. Treatment cultured ECs with inflammatory cytokines or angiogenic factors stimulated expression Cat S, whereas inhibition activity reduced microtubule formation by impairing cell invasion. from S–deficient mice showed collagenolytic and...
Objective— Although it has been reported that matrix metalloproteinase (MMP)-2 is a major proteinase in atherosclerotic plaque lesions, there no direct evidence of the role MMP-2 lesion formation. In present study we determined atherosclerosis development using apolipoprotein E-deficient (apoE −/− ) mice. Methods and Results— To generate MMP-2–deficient, apoE-deficient mice (MMP-2 :apoE ), were crossed with apoE After 8 weeks feeding lipid-rich diet, morphological biochemical studies aortic...
Abstract Exposure to chronic psychosocial stress is a risk factor for metabolic cardiovascular disorders. Dipeptidyl peptidase‐4 (DPP‐4) plays essential roles in human pathobiology, and we recently showed that DPP‐4 levels are increased by murine models. We here investigated the role of stress‐related cardiac injury dysfunction mice, focusing on oxidative apoptosis. Male mice were randomly assigned non‐stress two‐week immobilized‐stress groups biological morphological studies. On day 14...
The present study was designed to investigate the effect and relationship of endothelial function progenitor cells (EPCs) by green tea consumption in chronic smokers. numbers circulating EPCs have an inverse correlation with smoking dysfunction. Green catechin improved dysfunction smokers.In 20 young healthy smokers, functions, defined flow-mediated endothelium dependent vasodilation (FMD) brachial artery via ultrasound as well number isolated from peripheral blood, were determined at...
Objective— The development of a murine model atherosclerotic plaque rupture. Methods and Results— left common carotid arteries male apolipoprotein E (apoE)–deficient mice (9 weeks old) were ligated just proximal to their bifurcations. After 4 on standard diet, the received polyethylene cuff placement site, animals then processed for morphological studies at specific time points. Ligation artery in apoE-deficient induced marked intimal hyperplasia, which is lipid- collagen-rich lesion that...
Matrix metalloproteinases (MMPs) have been implicated in the process of neovascularization. However, exact roles individual MMPs vessel formation are poorly understood. To study putative role MMP-2 ischemia-induced neovascularization, a hindlimb ischemia model was applied to MMP-2(+/+) and MMP-2(-/-) mice. Serial laser Doppler blood-flow analysis revealed that recovery ischemic/normal ratio young old mice remained impaired throughout follow-up period. At day 35, microangiography...
Background— Exercise stimulates the vascular response in pathological conditions, including ischemia; however, molecular mechanisms by which exercise improves impaired hypoxia-induced factor (HIF)-1α–mediated to hypoxia associated with aging are poorly understood. Here, we report that swimming training (ST) modulates ischemia aged (24-month-old) mice. Methods and Results— Aged wild-type mice (MMP-2 +/+ ) maintained ST (swimming 1 h/d) from day after surgery were randomly assigned 4 groups...
Stressors contribute to thrombosis and insulin resistance. Since obesity-related adipose inflammation is also involved in these pathological states, we assumed that stress correlates with inflammation. Male mice were subjected 2-week intermittent restraint stress. Expression of plasma lipids, monocyte/macrophage markers (CD11b, CD68, F4/80), proinflammatory cytokines (monocyte chemoattractant protein-1 [MCP-1], tumor necrosis factor-α, interleukin-6), adiponectin, heat shock protein 70.1...
Objective— Cathepsin S (CatS) participates in atherogenesis through several putative mechanisms. The ability of cathepsins to modify histone tail is likely contribute stem cell development. Histone deacetylase 6 (HDAC6) required modulating the proliferation and migration various types cancer cells. Here, we investigated cross talk between CatS HADC6 injury-related vascular repair mice. Approach Results— Ligation injury carotid artery mice increased expression, CatS-deficient showed reduced...
Abstract Background Exercise train (ET) stimulates muscle response in pathological conditions, including aging. The molecular mechanisms by which exercise improves impaired adiponectin/adiponectin receptor 1 (AdipoR1)‐related actions associated with aging are poorly understood. Here we observed that a senescence‐accelerated mouse prone 10 (SAMP10) model, long‐term ET modulated muscle‐regenerative actions. Methods 25‐week‐old male SAMP10 mice were randomly assigned to the control and (45...
The aim of the present study was to examine relationship between depressive mood and diagnostic components sarcopenia.The used baseline data participants in Toyota Prevention Intervention for Cognitive Decline Sarcopenia study. Participants this cross-sectional were 432 older adults (46.5% women, mean age 72.5 ± 4.7 years). We defined sarcopenia using algorithm recommended by Asian Working Group Sarcopenia, all classified into a or healthy control group. skeletal muscle mass measured...
Abstract Background Skeletal muscle mass and function losses in aging individuals are associated with quality of life deterioration disability. Mesenchymal stromal cells exert immunomodulatory anti-inflammatory effects could yield beneficial aging-related degenerative disease. Methods results We investigated the efficacy umbilical cord-derived mesenchymal (UC-MSCs) on sarcopenia-related skeletal atrophy dysfunction senescence-accelerated mouse prone 10 (SAMP10) mice. randomly assigned...
Cathepsins are cysteine proteases that participate in various types of tissue remodeling. However, their expressions during myocardial remodeling have not been examined. In this study, we investigated the left ventricular (LV) myocardium rats and humans with hypertension-induced LV hypertrophy or heart failure (HF). Real-time PCR immunoblot analysis revealed abundance cathepsin S mRNA protein tissues was greater HF than those control subjects. Immunostaining showed localized predominantly to...