A5112862129- Protease and Inhibitor Mechanisms
- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- Angiogenesis and VEGF in Cancer
- Atherosclerosis and Cardiovascular Diseases
- Hormonal Regulation and Hypertension
- Exercise and Physiological Responses
- Peptidase Inhibition and Analysis
- Calpain Protease Function and Regulation
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Transgenic Plants and Applications
- Adipose Tissue and Metabolism
- Frailty in Older Adults
- S100 Proteins and Annexins
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuropeptides and Animal Physiology
- Diabetes Treatment and Management
- Retinoids in leukemia and cellular processes
- Virus-based gene therapy research
- Lipoproteins and Cardiovascular Health
- Viral Infectious Diseases and Gene Expression in Insects
- GDF15 and Related Biomarkers
- Balance, Gait, and Falls Prevention
Nagoya University
2016-2025
Nagasaki University
2022
Tokyo University of Agriculture and Technology
2022
Kurashiki Central Hospital
2019-2021
Yanbian University Hospital
2010-2017
Inoue Hospital
2011-2016
Nagoya University Hospital
2012-2016
Yanbian University
2013-2016
University of South Florida
2016
Kyung Hee University
2010-2016
To maintain and restore skeletal muscle mass function is essential for healthy aging. We have found that myonectin acts as a cardioprotective myokine. Here, we investigate the effect of on atrophy in various male mouse models dysfunction. Disruption exacerbates age-associated, sciatic denervation-induced or dexamethasone (DEX)-induced models. Myonectin deficiency also contributes to exacerbated mitochondrial dysfunction reduces expression biogenesis-associated genes including PGC1α...
Background— Exercise stimulates the vascular response in pathological conditions, including ischemia; however, molecular mechanisms by which exercise improves impaired hypoxia-induced factor (HIF)-1α–mediated to hypoxia associated with aging are poorly understood. Here, we report that swimming training (ST) modulates ischemia aged (24-month-old) mice. Methods and Results— Aged wild-type mice (MMP-2 +/+ ) maintained ST (swimming 1 h/d) from day after surgery were randomly assigned 4 groups...
Objective— Cathepsin S (CatS) participates in atherogenesis through several putative mechanisms. The ability of cathepsins to modify histone tail is likely contribute stem cell development. Histone deacetylase 6 (HDAC6) required modulating the proliferation and migration various types cancer cells. Here, we investigated cross talk between CatS HADC6 injury-related vascular repair mice. Approach Results— Ligation injury carotid artery mice increased expression, CatS-deficient showed reduced...
Abstract Background Exercise train (ET) stimulates muscle response in pathological conditions, including aging. The molecular mechanisms by which exercise improves impaired adiponectin/adiponectin receptor 1 (AdipoR1)‐related actions associated with aging are poorly understood. Here we observed that a senescence‐accelerated mouse prone 10 (SAMP10) model, long‐term ET modulated muscle‐regenerative actions. Methods 25‐week‐old male SAMP10 mice were randomly assigned to the control and (45...
Abstract Background Skeletal muscle mass and function losses in aging individuals are associated with quality of life deterioration disability. Mesenchymal stromal cells exert immunomodulatory anti-inflammatory effects could yield beneficial aging-related degenerative disease. Methods results We investigated the efficacy umbilical cord-derived mesenchymal (UC-MSCs) on sarcopenia-related skeletal atrophy dysfunction senescence-accelerated mouse prone 10 (SAMP10) mice. randomly assigned...
Exposure to psychosocial stress is a risk factor for cardiovascular disease, including vascular aging and regeneration. Given that dipeptidyl peptidase-4 (DPP4) regulates several intracellular signaling pathways associated with the glucagon-like peptide-1 (GLP-1) metabolism, we investigated role of DPP4/GLP-1 axis in senescence ischemia-induced neovascularization mice under chronic stress, special focus on adiponectin -mediated peroxisome proliferator activated receptor-γ/its co-activator 1α...
Background Exposure to chronic psychosocial stress is a risk factor for atherosclerosis‐based cardiovascular disease. We previously demonstrated the increased expressions of cathepsin S (CatS) in atherosclerotic lesions. Whether CatS participates directly stress‐related neointimal hyperplasia has been unknown. Methods and Results Male wild‐type CatS‐deficient mice that underwent carotid ligation injury were subjected immobilization morphological biochemical studies at specific times. On day...
Abstract Background Exposure to chronic psychological stress (CPS) is a risk factor for thrombotic cardiocerebrovascular diseases (CCVDs). The expression and activity of the cysteine cathepsin K (CTSK) are upregulated in stressed cardiovascular tissues, we investigated whether CTSK involved stress-related thrombosis, focusing on serum-induced endothelial apoptosis. Methods results Eight-week-old wild-type male mice (CTSK +/+ ) randomly divided non-stress 3-week restraint groups received left...
The interactions between the renin-angiotensin system and neovascularization in atherosclerotic plaque development are unclear. We investigated effects of angiotensin II type 1 receptor antagonism pathogenesis atherosclerosis apolipoprotein E-deficient (ApoE(-/-)) mice with a special focus on neovascularization. ApoE(-/-) fed high-fat diet were randomly assigned to 2 groups administered vehicle or olmesartan for 12 weeks. Quantification areas at aortic root thoracic abdominal aorta revealed...
Cathepsin K (CatK) is one of the most potent mammalian collagenases. We showed previously increased expression CatK in human and animal atherosclerotic lesions. Here, we hypothesized that ablation mitigates injury-induced neointimal hyperplasia. Male wild-type (CatK +/+ ) CatK-deficient −/− mice underwent ligation or a combination polyethylene cuff-replacement injuries to right common carotid artery just proximal its bifurcation, they were then processed for morphological biochemical studies...
Exposure to chronic psychological stress is a risk factor for metabolic cardiovascular disease. Given the important role of lysosomal CTSS (cathepsin S) in human pathobiology, we examined stress-related thrombosis, focusing on inflammation, oxidative stress, and apoptosis.Six-week-old wild-type mice (CTSS+/+) CTSS-deficient (CTSS-/-) randomly assigned nonstress 2-week immobilization groups underwent iron chloride3 (FeCl3)-induced carotid thrombosis surgery morphological biochemical...
Abstract Exposure to chronic psychological stress (CPS) is an intractable risk factor for inflammatory and metabolic diseases. Lysosomal cysteinyl cathepsins play important role in human pathobiology. Given that cathepsin S (CTSS) upregulated the stressed vascular adipose tissues, we investigated whether CTSS participates stress-induced skeletal muscle mass loss dysfunction, with a special focus on protein imbalance apoptosis. Eight-week-old male wildtype (CTSS +/+ ) CTSS-knockout −/− mice...
DPP4 (Dipeptidyl peptidase-4)-GLP-1 (glucagon-like peptide-1) and its receptor (GLP-1R) axis has been involved in several intracellular signaling pathways. The Adrβ3 (β3-adrenergic receptor)/CXCL12 (C-X-C motif chemokine 12) signal was required for the hematopoiesis. We investigated novel molecular requirements between DPP4-GLP-1/GLP-1 Adrβ3/CXCL12 signals bone marrow (BM) hematopoietic stem cell (HSC) activation response to chronic stress.Male 8-week-old mice were subjected 4-week...
Abstract Background Cathepsin K (CatK) is a widely expressed cysteine protease that has gained attention because of its enzymatic and non‐enzymatic functions in signalling. Here, we examined whether CatK‐deficiency (CatK −/− ) would mitigate injury‐related skeletal muscle remodelling fibrosis mice, with special focus on inflammation cell apoptosis. Methods Cardiotoxin (CTX, 20 μM/200 μL) was injected into the left gastrocnemius male wild‐type +/+ CatK mice were processed for morphological...
Background Although apoptosis and cell proliferation have been extensively investigated in atherosclerosis restenosis postinjury, the communication between these 2 cellular events has not evaluated. Here, we report an inextricable communicative link smooth muscle promotion of vascular remodeling postinjury. Methods Results Cathepsin K–mediated caspase‐8 maturation is a key initial step for oxidative stress–induced apoptosis. Apoptotic cells generate potential growth‐stimulating signal to...
Abstract Background Cachexia is a complicated metabolic disorder that characterize by progressive atrophy of skeletal muscle. Cathepsin K (CTSK) widely expressed cysteine protease has garnered attention because its enzymatic and non‐enzymatic functions in signalling various pathological conditions. Here, we examined whether CTSK participates cancer‐induced muscle loss dysfunction, focusing on protein imbalance. Methods Male 9‐week‐old wild‐type (CTSK +/+ , n = 10) CTSK‐knockout −/− mice were...
Chronic psychological stress is a risk factor for kidney disease, including dysfunction and hypertension. Lysosomal CatK (cathepsin K) participates in various human pathobiologies. We investigated the role of remodeling hypertension response to 5/6 nephrectomy injury mice with or without chronic stress.Male 7-week-old WT (wild type; CatK+/+) CatK-deficient (CatK-/-) that were not subjected underwent nephrectomy. At 8 weeks post-stress/surgery, was observed have accelerated injury-induced...