A5049626446- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Nanoparticle-Based Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Advanced Drug Delivery Systems
- ATP Synthase and ATPases Research
- Drug Solubulity and Delivery Systems
- Phytochemistry and Bioactivity Studies
- Protein purification and stability
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Graphene and Nanomaterials Applications
- Molecular Junctions and Nanostructures
- Phytochemistry and Biological Activities
- Pancreatic function and diabetes
- 3D Printing in Biomedical Research
- SARS-CoV-2 and COVID-19 Research
- Bioactive Compounds and Antitumor Agents
- Mesenchymal stem cell research
- Nanoplatforms for cancer theranostics
- Phytochemistry and Bioactive Compounds
- Free Radicals and Antioxidants
University of Jordan
2019-2024
King Hussein Cancer Center
2021-2023
Nucleic acid therapeutics are rapidly expanding because of recent advancements in production and purification. This class may change the field disease treatment personalized medicine since it can cure diseases. However, drug delivery systems crucial for these to fulfill their potential. Liposomes have long been considered ideal platforms systemic drugs delivery. Considering development cancer therapeutics, this work emphases on current liposomes' Nano-formulations, functionalization, design...
Quinones are a class of cyclic organic compounds that widely distributed in nature and have been shown to exhibit anti-inflammatory, antioxidant, anticancerous activities. However, the molecular mechanisms/signaling by which these molecules exert their effect still not fully understood. In this study, group quinone-derived were examined for potential inhibitory against human IRAK1 IRAK4 kinases vitro. We identified five compounds: 1,4-naphthoquinone, emodin, shikonin, plumbagin, menadione...
Aptamers offer a great opportunity to develop innovative drug delivery systems that can deliver cargos specifically into targeted cells. In this study, chimera consisting of two aptamers was developed doxorubicin cancer cells and release the in cytoplasm response adenosine-5′-triphosphate (ATP) binding. The composed AS1411 anti-nucleolin aptamer for cell targeting ATP loading triggering first produced by hybridizing with its complementary DNA sequence, which is linked via poly-thymine...
The neonatal Fc receptor (FcRn) has been established as a major factor in regulating the metabolism of albumin and IgG humans by protecting them from intracellular degradation after they are endocytosed into cells. We assume that increasing levels endogenous FcRn proteins cells would be beneficial to enhance recycling these molecules. In this study, we identify compound 1,4-naphthoquinone an efficient stimulator protein expression human THP-1 monocytic with potency at submicromolar range....
Column chromatography (CC) analysis of methanol and butanol extracts the aerial parts Calortopis procera as well extract its latex, led to isolation 8 cardenolides, which structures were elucidated by NMR HRESIMS spectroscopy. They also revealed several triterpenes flavonoid glycoside. Based on antiproliferative activity reported for calotropin calotoxin was tested against two common cancer cell lines, human triple-negative breast line (MDA-MB-231) lung adenocarcinoma (A549). The high...
Gold nanoparticles (AuNPs) are one of the most stable that have been prevalently used as examples for biological and biomedical applications. Herein, we evaluate effect AuNPs on processes dental pulp stem cells derived from exfoliated deciduous teeth (SHED). Two different shapes PEGylated AuNPs, rods (AuNR-PEG) spheres (AuNS-PEG), were prepared characterized. SHED treated with concentrations AuNR-PEG AuNS-PEG to determine their stemness profile (SCs), proliferation, cytotoxicity, cellular...
Adopting conventional conjugation approaches to construct antibody-targeted nanoparticles (NPs) has demonstrated suboptimal control over the binding orientation and structural stability of monoclonal antibodies (mAbs). Hitherto, developed NPs have shown proof concept but lack product homogeneity, batch-to-batch reproducibility, stability, precluding their advancement toward clinic. To circumvent these limitations advance clinical application, herein, a refined approach based on site-specific...