A5034716236- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Electron Spin Resonance Studies
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- COVID-19 epidemiological studies
- Lanthanide and Transition Metal Complexes
- Synthesis and biological activity
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- COVID-19 Clinical Research Studies
- Bee Products Chemical Analysis
- Receptor Mechanisms and Signaling
- MicroRNA in disease regulation
- Magnetism in coordination complexes
- Infant Nutrition and Health
- Bacillus and Francisella bacterial research
- Viral gastroenteritis research and epidemiology
- Healthcare and Venom Research
- Cytokine Signaling Pathways and Interactions
- Tuberculosis Research and Epidemiology
- Microencapsulation and Drying Processes
- Folate and B Vitamins Research
- Protein Structure and Dynamics
Hashemite University
2015-2024
University of Southern California
2008-2012
Background: Since the coronavirus disease 2019 (COVID-19) was declared a pandemic, there no doubt that vaccination is ideal protocol to tackle it. Within year, few COVID-19 vaccines have been developed and authorized. This unparalleled initiative in developing created many uncertainties looming around efficacy safety of these vaccines. study aimed assess side effects perceptions following Jordan. Methods: A cross-sectional conducted by distributing an online survey targeted toward Jordan...
Type II endometrial cancers (uterine serous papillary and clear cell histologies) represent rare but highly aggressive variants of cancer (EC). HER2 EGFR may be differentially expressed in type EC. Here, we evaluate the clinical role a large cohort surgically staged patients with (nonendometrioid) EC compare findings those seen representative I (endometrioid) In this study gene amplification was studied by fluorescence situ hybridisation (FISH) expression immunohistochemistry. Tissue...
Background: The unprecedented global spread of coronavirus disease 2019 (COVID-19) has imposed huge challenges on the healthcare facilities, and impacted every aspect life. This led to development several vaccines against COVID-19 within one year. study aimed assess attitudes side effects among Arab communities after receiving a vaccine use machine learning (ML) tools predict post-vaccination based predisposing factors. Methods: An online-based multinational survey was carried out via social...
Echinomycin was loaded into PEGylated pH-sensitive liposomes and functionalized with anti-nucleolin aptamer for selective targeting pH-responsive release of echinomycin cancer cells.
Abstract Electron paramagnetic resonance using site‐directed spin labeling can be used as an approach for determination of protein structures that are difficult to solve by other methods. One important aspect this is the measurement interlabel distances double electron–electron (DEER) method. Interpretation experimental data could facilitated a computational calculation distances. We describe algorithm, PRONOX, rapid computation based on label conformer distributions at any site protein. The...
The condensation of bacteriophage phi29 genomic DNA into its preformed procapsid requires the packaging motor, which is strongest known biological motor. motor an intricate ring-shaped protein/RNA complex, and function RNA component called (pRNA). Current structural information on pRNA limited, hinders studies function. Here, we used site-directed spin labeling to map conformation a three-way junction that bridges binding sites for ATPase procapsid. were carried out dimer, simplest complex...
Aptamers are molecules that reveal highly complex and refined molecular recognition properties. These capable of binding with high affinity selectivity to targets, ranging from small whole living cells. Several aptamers have been selected for targeting cellular proteins they also used in developing therapeutics diagnostic strategies. Epithelial cell adhesion molecule (EpCAM) is considered as a cancer stem (CSC) biomarker one the most promising targets aptamer selection against CSCs. In this...
Here, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-pot procedure for reaction β-dicarbonyl compounds (ethylacetoacetate, 5,5-dimethyl-1,3-cyclohexadione or 1,3-cyclohexadionone) with N,N-dimethylformamide dimethylacetal, followed by addition 2-hydrazinyl-4,6-disubstituted-s-triazine either in ethanol-acetic acid neat acetic to afford a pyrazole and pyrazole-fused cycloalkanone systems. The synthetic protocol proved be efficient, shorter time high...
Quinones are a class of cyclic organic compounds that widely distributed in nature and have been shown to exhibit anti-inflammatory, antioxidant, anticancerous activities. However, the molecular mechanisms/signaling by which these molecules exert their effect still not fully understood. In this study, group quinone-derived were examined for potential inhibitory against human IRAK1 IRAK4 kinases vitro. We identified five compounds: 1,4-naphthoquinone, emodin, shikonin, plumbagin, menadione...
Despite the wide distribution of COVID-19 vaccines, refugees remain last in line for intake vaccines. Syrian Jordan reach up to 700,000 registered and almost unregistered refugees. This study aims assess willingness take vaccine. Participants Zaatari refugee camp were invited through social media complete survey between January March 2022. A total 230 participated our study, with half participants male gender. The majority had secondary school as their highest education level unemployed,...
We found that several major chromosomal fragile sites in human lymphomas, including the bcl-2 breakpoint region, bcl-1 translocation cluster, and c-Myc exon 1-intron 1 boundary, contain distinctive sequences of consecutive cytosines exhibiting a high degree reactivity with structure-specific chemical probe bisulfite. To assess inherent structural variability duplex DNA these regions to determine range structures reactive bisulfite, we have performed bisulfite probing on genomic vitro situ;...
Combinatorial therapeutic strategies using siRNA and small molecules to eradicate tumors are emerging. Targeting multiple signaling pathways decreases the chances of cancer cells switching adapting new processes that may occur when a single modality. Aberrant functioning Notch-1, Wnt/β-catenin, STAT3 proteins their crosstalk have been found be involved in tumor survival, drug resistance, relapse. In current study, we describe potential combinations designed for silencing MCF7_DoxS (wild...
Artificial intelligence (AI) has huge potential to accelerate drug discovery, but challenges remain in implementing AI algorithms that can be used by the broad scientific community. Identification of molecular features and their subsequent use training machine learning models may permit prediction new molecules with enhanced properties. Predictive modeling is particularly applicable analysis structure-activity relationships (SARs) would a useful tool hands laboratory medicinal chemists. This...
Echinomycin is a natural compound discovered and isolated from bacteria, introduced as promising antibiotic anticancer therapy. However, it failed clinically due to improper formulations short half-life. After the unsuccessful clinical trials, echinomycin was overlooked. Recently, new mechanism of action has given some hope for reviving an inhibitor hypoxia-inducible factor (HIF-1). In 2015, received orphan drug designation treating acute myeloid leukemia in USA. Furthermore, advancements...