A5014071584- Invertebrate Immune Response Mechanisms
- Insect Utilization and Effects
- Insect symbiosis and bacterial influences
- Antimicrobial Peptides and Activities
- Immune Cell Function and Interaction
- Neurobiology and Insect Physiology Research
- Insect Resistance and Genetics
- Studies on Chitinases and Chitosanases
- Hippo pathway signaling and YAP/TAZ
- Exercise and Physiological Responses
- Tracheal and airway disorders
- Single-cell and spatial transcriptomics
- Developmental Biology and Gene Regulation
- Galectins and Cancer Biology
- Entomopathogenic Microorganisms in Pest Control
- Evolution and Genetic Dynamics
- CRISPR and Genetic Engineering
Stockholm University
2019-2023
Wenner-Gren Foundations
2020-2023
Epithelial organ size and shape depend on cell changes, cell–matrix communication, apical membrane growth. The Drosophila melanogaster embryonic tracheal network is an excellent model to study these processes. Here, we show that the transcriptional coactivator of Hippo pathway, Yorkie (YAP/TAZ in vertebrates), plays distinct roles developing airways. exerts a cytoplasmic function by binding Twinstar, orthologue vertebrate actin-severing protein Cofilin, regulate F-actin levels size, which...
Introduction Tumor-associated macrophages may act to either limit or promote tumor growth, yet the molecular basis for path is poorly characterized. Methods We use a larval Drosophila model that expresses dominant-active version of Ras-oncogene (Ras V12 ) study dysplastic growth during early progression. performed single-cell RNA-sequencing macrophage-like hemocytes characterize these cells in tumor- compared wild-type larvae. Hemocytes included manually extracted tumor-associated- and...
Postmitotic tissues are incapable of replacing damaged cells through proliferation, but need to rely on buffering mechanisms prevent tissue disintegration. By constitutively activating the Ras/MAPK-pathway via Ras V12 -overexpression in postmitotic salivary glands (SGs) Drosophila larvae, we overrode adaptability growth signals and induced hypertrophy. The accompanied loss integrity, recognition by cellular immunity, cell death all buffered blocking stress signaling a genuine...
Fibrotic lesions accompany several pathological conditions, including tumors. We show that expression of a dominant-active form the Ras oncogene in Drosophila salivary glands (SGs) leads to redistribution components basement membrane (BM) and fibrotic lesions. Similar types mammalian fibrosis, disturbed BM attracts clot components, insect transglutaminase phenoloxidase. SG epithelial cells reduced apicobasal polarity accompanied by loss secretory activity. Both cell are alleviated ectopic...
Introduction Chitinase-like proteins (CLPs) are associated with tissue-remodeling and inflammation but also several disorders, including fibrosis, atherosclerosis, allergies, cancer. However, CLP’s role in tumors is far from clear. Methods Here, we utilize Drosophila melanogaster molecular genetics to investigate the function of CLPs (imaginal disc growth factors; Idgf’s) Ras V12 dysplastic salivary glands. Results discussion We find one Idgf’s members, Idgf3 , transcriptionally induced a...
Abstract Fibrotic lesions accompany several pathological conditions including tumors. We show that expression of a dominant-active form the Ras oncogene in Drosophila salivary glands (SGs) leads to redistribution components basement membrane (BM) and fibrotic lesions. Similar types mammalian fibrosis, disturbed BM attracts clot insect transglutaminase phenoloxidase. SG epithelial cells reduced apico-basal polarity accompanied by loss secretory activity. Both cell are alleviated ectopic...
Abstract Introduction Tumor-associated macrophages may act to either limit or promote tumor growth, yet the molecular basis for path is poorly characterized. Methods We use a larval Drosophila model that expresses dominant-active version of Rasoncogene (Ras V12 ) study dysplastic growth during early progression. performed single-cell RNA-sequencing macrophage-like hemocytes characterize these cells in tumor-compared wild type larvae. Hemocytes included manually extracted tumor-associated-as...
Abstract Postmitotic tissues are incapable of replacing damaged cells through proliferation, but need to rely on buffering mechanisms prevent tissue disintegration. By constitutively activating the Ras/MAPK-pathway via Ras V12 -overexpression in postmitotic salivary glands Drosophila larvae, we overrode adaptability growth signals, induced hypertrophy and stress accumulation. This allowed us decipher a novel, spatio-temporally regulated interaction between JNK-stress response genuine...
Abstract Chitinase-like proteins (CLPs) are associated with tissue-remodeling and inflammation but also several disorders, including fibrosis, atherosclerosis, allergies, cancer. However, CLP’s role in tumors is far from clear. Here, we utilize Drosophila melanogaster to investigate the function of CLPs (imaginal disc growth factors; Idgf’s) Ras V12 dysplastic salivary glands. We find one Idgf’s members, Idgf3 , transcriptionally induced a JNK-dependent manner via positive feedback loop...