A5049977264- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Reactions
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Polyamine Metabolism and Applications
- Sulfur-Based Synthesis Techniques
- Molecular Sensors and Ion Detection
- Supramolecular Self-Assembly in Materials
- Supramolecular Chemistry and Complexes
- Enzyme Catalysis and Immobilization
- Advanced machining processes and optimization
- Microbial Metabolites in Food Biotechnology
- Atomic and Subatomic Physics Research
- Asymmetric Hydrogenation and Catalysis
- Radical Photochemical Reactions
- Membrane Separation Technologies
- Fluorine in Organic Chemistry
- Grouting, Rheology, and Soil Mechanics
- Composite Material Mechanics
- Catalysis and Oxidation Reactions
- Tunneling and Rock Mechanics
- Synthesis and Biological Activity
- Analytical Chemistry and Chromatography
Huazhong University of Science and Technology
2016-2025
PowerChina (China)
2024-2025
University of Michigan
2024
Air Force Medical University
2023
Georgia Institute of Technology
2005-2020
Novartis (China)
2020
The Wallace H. Coulter Department of Biomedical Engineering
2020
Emory University
2020
AID Atlanta
2020
Xi'an Medical University
2019
Resolving complex systems: The formation of a dynamic hemithioacetal system and its application toward the discovery β-galactosidase inhibitors were successfully investigated. designed system, which has virtual character in neutral aqueous media, was subjected to direct situ identification best by 1H STD NMR spectroscopy (ONPG: o-nitrophenyl-β-galactopyranoside).
With the advancement of ecological and environmental protection construction, research on modification expansive soil using environmentally friendly polymers can make up for harm to environment caused by traditional modification. Mechanical microscopic properties modified soils were analyzed through indoor tests. The results showed that liquid limit plasticity index decreased 52.14% 77.36%, respectively, plastic increased 20.83%. Maximum dry density 5.11% optimum moisture content 28.47%....
Organotin-mediated regioselective protection has been extensively used in organic synthesis for many years. However, the mechanistic origin of resulting regioselectivity is still not clear. By comparison steric and stereoelectronic effects controlling geometry five-membered rings formed from neighboring group participation, intramolecular acyl migration, or orthoester transesterification on pyranoside rings, a theory pattern reaction with dibutyltin oxide presented. It thus suggested that...
The presence of surfaces influences the kinetics amyloid-β (Aβ) peptide fibrillation. Although it has been generally recognized that fibrillation process can be assisted or accelerated by surface chemistry, impact topography, i.e., roughness, on is relatively little understood. Here we study role roughness surface-mediated using polymer coatings varying as well microparticles. Using single-molecule tracking, atomic force microscopy, and thioflavin T fluorescence technique, show a rough...
We propose a principle for H-bonding activation in acylation of hydroxyl groups, where the is activated by formation hydrogen bonds between groups and anions. With guidance this principle, we demonstrate method selective carbohydrates. By method, diols polyols are regioselectively acetylated high yields under mild conditions using catalytic amounts acetate. In comparison to other methods involving reagents such as organotin, organoboron, organosilicon, organobase, metal salts, more...
Abstract An efficient one‐pot method for the selective benzylation of diols and polyols using 0.1 equiv. organotin reagents tetrabutylammonium bromide as catalyst has been developed. The containing a cis ‐vicinal diol were regioselectively benzylated in 70–94% isolated yields. A catalytic reaction mechanism was also proposed. magnified image
Abstract In this study, [Fe(dibm) 3 ] (dibm=diisobutyrylmethane) is shown to have unusually broad scope as a catalyst for the selective monoalkylation of diverse set 1,2‐ and 1,3‐diol‐containing structures. The mechanism proposed proceed via cyclic dioxolane‐type intermediate, formed between iron(III) species two adjacent hydroxyl groups. This approach represents first transition‐metal catalysts that are able replace stoichiometric amounts organotin reagents in regioselective alkylation....
[reaction: see text] The Lattrell-Dax method of nitrite-mediated substitution carbohydrate triflates is an efficient to generate structures inverse configuration. In the present study, epimerization gluco- and galactopyranoside derivatives corresponding allo- gulopyranoside by triflation/nitrite treatment has been investigated. It was found that a neighboring ester group essential for reactivity triflate inversion. Furthermore, good inversion yield also depended on relative configuration...
Organosilicon-mediated, regioselective acetylation of vicinal- and 1,3-diols is presented. Methyl trimethoxysilane or dimethyl dimethoxysilane was first used to form cyclic 1,3,2-dioxasilolane 1,3,2-dioxasilinane intermediates, subsequent acetate-catalyzed monoacylation efficiently performed by addition acetic anhydride acetyl chloride under mild conditions. The reaction exhibited high regioselectivity, resulting in the same protection pattern as organotin-mediated schemes.
We demonstrated <sup>−</sup>OH as the deacylation catalyst in methanol, indicating that Zemplén condition had been misleading us for almost 90 years.
H-bonding activation in the regioselective acetylation of vicinal and 1,3-diols is presented. Herein, hydroxyl group with acetic anhydride can be activated by formation H-bonds between anions. The reaction exhibits high regioselectivity when a catalytic amount tetrabutylammonium acetate employed. Mechanistic studies indicated that anion forms dual complexes diol, which facilitates subsequent monoacetylation.
Zeolite Y nanoparticle assemblies with mesoporous structure has good catalytic performance in the Ritter reaction.
In this study, we have successfully applied a visible-light-promoted desulfurization method to the synthesis of deoxysugars, especially 1-deoxyglycose, 2,4-deoxyglycosides, and 2-deoxyglycosides with exclusive α-configuration. Compared reported under UV light (500 W mercury lamp), visible (20 blue LED) is easy operate since it does not require dedicated photochemical reactor, occurs very mild conditions, able avoid many side reactions that often occur during UV-induced desulfurization.
Abstract A direct and highly convenient organocatalytic method for the preparation of 1,5‐dialdo‐pyranosides 1,4‐dialdo‐furanosides is presented. The relies on chemoselective properties TEMPO in combination with trichloroisocyanuric acid under very mild, basic conditions. Unprotected glycosides are prepared a single step high yields efficiently purified use solid‐phase imine capture. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
A neighboring equatorial ester group plays a highly important role in the Lattrell-Dax (nitrite-mediated) carbohydrate epimerization reaction, inducing formation of inversion compounds good yields. On basis this effect, efficient synthetic routes to beta-D-mannosides and beta-D-talosides, from corresponding beta-D-galactosides beta-D-glucosides, have been designed. The present are based on multiple regioselective acylation via respective stannylene intermediates, followed by inversions...
An efficient copper-catalyzed radical decarboxylative imidation reaction is presented.
LCZ696 is a novel treatment for patients suffering from heart failure that combines the two active pharmaceutical ingredients sacubitril and valsartan in single chemical compound. While an established drug substance, new manufacturing process suitable large-scale commercial production had to be developed sacubitril. The use of chemocatalysis, biocatalysis, flow chemistry as state-of-the-art technologies allowed efficiently build up structure achieve defined performance targets.
Regioselective control in organotin-mediated multiple acylation of carbohydrates is presented. The reagent could be efficiently used to direct the product formation. Reagent-dependent thermodynamic and kinetic dynamic assistance mechanisms are suggested, resulting efficient preparation building blocks that normally require many steps with traditional synthesis.
In previous studies, it was reported that a neighbouring equatorial ester group is essential for good yield of nitrite-mediated triflate inversion, whereas with benzyl ether groups or axial groups, mixtures are generally produced. the present study, origin this difference addressed. The ambident reactivity nitrite ion has been found to be cause complex product formation observed, which can controlled by group. Both N-attack and O-attack occur in absence group, favoured its presence. A...
Here we present the generation of uniform microparticles with tunable diameters from azobenzene-based homopolymer by combining microfluidics technique and emulsion-solvent evaporation route. In addition, photoinduced deformation behavior these microspheres, irradiated a linearly polarized beam different irradiation time direction, are systemically studied. The process through real optical microscope observation can be investigated, benefiting microscaled size polymer particles. These results...
This study was performed to develop a highly efficient method whereby desulfurization could be completed in 0.5 h under ultraviolet light, at room temperature, and the presence of trialkylphosphine. Using this method, deoxyglycosides produced from sulfur-containing glycosides almost quantitative yields. The much higher reactivity with triethylphosphine versus that triethylphosphite is also discussed.