A5010402848- Knee injuries and reconstruction techniques
- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Periodontal Regeneration and Treatments
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Orthopaedic implants and arthroplasty
- Bone and Joint Diseases
- Sports injuries and prevention
- Musculoskeletal Disorders and Rehabilitation
- Bone fractures and treatments
- Lower Extremity Biomechanics and Pathologies
- History of Medicine Studies
- History of Medical Practice
- Medical and Biological Sciences
- Orthopedic Surgery and Rehabilitation
- Anatomy and Medical Technology
- Medical History and Innovations
- Medical and Biological Ozone Research
- Orthopedic Infections and Treatments
- Mesenchymal stem cell research
- Foot and Ankle Surgery
- Myofascial pain diagnosis and treatment
- Shoulder and Clavicle Injuries
- Therapeutic Uses of Natural Elements
Humanitas University
2017-2025
IRCCS Humanitas Research Hospital
2021-2025
Sechenov University
2020-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Institute of Biomedical Science
2023
San Salvatore Hospital
2021
Clinical Orthopaedics and Related Research
2019
Istituto Ortopedico Rizzoli
2009-2017
Orthopedic Institute
2009-2017
Creative Research Enterprises (United States)
2016
Abstract Background Platelet Rich Plasma (PRP), a blood-derived product rich in growth factors, is promising treatment for cartilage defects but there still lack of clinical evidence. The aim this study to show, through randomized double blind prospective trial, the efficacy procedure, by comparing PRP Hyaluronic Acid (HA) injections knee chondropathy or osteoarthritis (OA). Methods 109 patients (55 treated with HA and 54 PRP) were evaluated at 12 months follow-up. enrolled according...
Background: Osteoarthritis (OA) is a common disease that will affect almost half the population at some point in their lives through pain and decreased functional capacity. New nonoperative options are being proposed to treat earlier stages of joint degeneration provide symptomatic relief delay surgical intervention. Purpose: To evaluate benefit provided by platelet-rich plasma (PRP) injections knee comparison with hyaluronic acid (HA), most injective treatment currently adopted for this...
Background: Platelet-rich plasma (PRP) injections have been proposed as a new conservative option for knee degeneration to provide symptomatic relief and delay surgical intervention. Although the current literature provides some evidence on benefits of this technique compared with viscosupplementation, no studies performed compare their long-term effects. Purpose: To clinical outcomes provided by intra-articular either PRP or hyaluronic acid (HA) treat degenerative disease. Study Design:...
Chronic Achilles tendinopathy is responsible for a severe reduction in physical performance and persistent pain. There currently number of therapeutic options the local administration growth factors an emerging treatment strategy. In particular, platelet-rich plasma (PRP) widely used way to provide regenerative stimulus tendon healing. The aim this study was document mid-term results obtained after treating recalcitrant with injections high concentrate, leucocyte-rich PRP.Twenty-seven...
Ozone therapy (OT) is used for the treatment of multiple musculoskeletal disorders. In recent years, there has been a growing interest in its use osteoarthritis (OA). The aim this double-blind randomized controlled trial was to evaluate efficacy OT compared with hyaluronic acid (HA) injections pain relief patients knee OA. Patients OA at least three months were included and randomly assigned receive intra-articular ozone or HA (once week). assessed baseline 1, 3, 6 after pain, stiffness,...
Background: Lesions of the articular cartilage, with or without involvement subchondral bone, are a common cause pain and dysfunction in knee. Although several treatment options have been developed, majority previous clinical trials examined patients isolated focal midsized defects, which rarely represent condition found general population. Rather, cartilage lesions often associated presence mild to moderate osteoarthritic changes. Purpose: The present multicenter randomized controlled trial...
Objectives Matrix-assisted autologous chondrocyte transplantation (MACT) has been developed and applied in the clinical practice last decade to overcome most of disadvantages first generation procedures. The purpose this systematic review is document analyse available literature on results MACT treatment chondral osteochondral lesions knee. Methods All studies published English addressing procedures were identified, including those that fulfilled following criteria: 1) level I-IV evidence,...
Matrix-assisted autologous chondrocyte transplantation (MACT) was developed to overcome the limitations of first-generation implantation. Although short-term/midterm results are now available for a small series patients, literature still lacks studies on large cohorts patients evaluated at midterm/long-term follow-up.Not all can have same benefit from this procedure. The aim study is analyze cohort treated with hyaluronan-based MACT perform clinical profiling and highlight patient-...
The presence of leukocytes in platelet concentrates is deemed to cause deleterious effects when injected intra articularly. aim this study analyse both local and systemic induced by leukocyte-rich Platelet-rich Plasma (PRP) injections through a proteomic characterization serial synovial fluid blood samples obtained from subjects treated for knee OA. Secondary was compare the on homeostasis response with those visco-supplementation.Thirty-six OA patients either autologous L-PRP or HA...
In recent years biological strategies are being more widely used to treat cartilage lesions. One of the most exploited novel treatments is Platelet-rich Plasma (PRP), whose high content growth factors supposed determine a regenerative stimulus cartilaginous tissue. Despite many promising in vitro and vivo studies, when discussing clinical application clear indication for use PRP cannot be assessed. There initial encouraging data, but only few randomized controlled trials have been published,...