A5037592391- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Periodontal Regeneration and Treatments
- Lower Extremity Biomechanics and Pathologies
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Orthopedic Infections and Treatments
- Bone Tissue Engineering Materials
- Bone fractures and treatments
- Adhesion, Friction, and Surface Interactions
- Shoulder and Clavicle Injuries
- Mesenchymal stem cell research
- Metal and Thin Film Mechanics
- Bone and Joint Diseases
- Hip disorders and treatments
- Musculoskeletal Disorders and Rehabilitation
- Foot and Ankle Surgery
- Advanced materials and composites
- Dental Implant Techniques and Outcomes
- Anatomy and Medical Technology
- Medical and Biological Sciences
Humanitas University
2017-2024
Istituto Ortopedico Rizzoli
2012-2024
IRCCS Humanitas Research Hospital
2017-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2023
Institute of Biomedical Science
2023
University of Bologna
2011-2020
Fondazione Humanitas per la Ricerca
2017-2020
Clinical Orthopaedics and Related Research
2018-2019
Tecnologie Avanzate (Italy)
2005-2018
Smith College
2018
The ability of marrow-derived osteoprogenitor cells to promote repair critical-size tibial gaps upon autologous transplantation on a hydroxyapatite ceramic (HAC) carrier was tested in sheep model. Conditions for vitro expansion bone marrow stromal (BMSC) were established and the osteogenic potential expanded validated. Ectopic implantation BMSC immunocompromised mice led extensive formation. When used sheep, cell-loaded implants (n = 2) conducted far more formation than did cell-free HAC...
Extensive bone loss is still a major problem in orthopedics. A number of different therapeutic approaches have been developed and proposed, but so far none proven to be fully satisfactory. We used new tissue engineering approach treat four patients with large diaphysis defects poor alternatives. To obtain implantable three-dimensional (3D) living constructs, cells isolated from the patients' marrow stroma were expanded culture seeded onto porous hydroxyapatite (HA) ceramic scaffolds designed...
The use of tissue engineering for cartilage repair has emerged as a potential therapeutic option and led to the development Hyalograft® C, tissue-engineered graft composed autologous chondrocytes grown on scaffold entirely made HYAFF® 11, an esterified derivative hyaluronic acid. Here we present results ongoing multicenter clinical study conducted with primary objective investigate subjective symptomatic, functional health-related quality life outcomes patients treated C. Clinical cohort 141...
Various approaches have been proposed to treat articular cartilage lesions, which are plagued by inherent limited healing potential.To compare the clinical outcome of patients treated with second-generation autologous chondrocyte implantation implants those microfracture repair technique at 5-year follow-up.Cohort study; Level evidence, 2.Eighty active (mean age, 29.8 years) and grade III IV lesions femoral condyles or trochlea were arthroscopic Hyalograft C (40 per group). Patients achieved...
Abstract Background Platelet Rich Plasma (PRP), a blood-derived product rich in growth factors, is promising treatment for cartilage defects but there still lack of clinical evidence. The aim this study to show, through randomized double blind prospective trial, the efficacy procedure, by comparing PRP Hyaluronic Acid (HA) injections knee chondropathy or osteoarthritis (OA). Methods 109 patients (55 treated with HA and 54 PRP) were evaluated at 12 months follow-up. enrolled according...
Background: Osteoarthritis (OA) is a common disease that will affect almost half the population at some point in their lives through pain and decreased functional capacity. New nonoperative options are being proposed to treat earlier stages of joint degeneration provide symptomatic relief delay surgical intervention. Purpose: To evaluate benefit provided by platelet-rich plasma (PRP) injections knee comparison with hyaluronic acid (HA), most injective treatment currently adopted for this...
Platelet-Rich Plasma (PRP) is a low-cost procedure to deliver high concentrations of autologous growth factors (GFs). Platelet activation crucial step that might influence the availability bioactive molecules and therefore tissue healing. Activation PRP from ten voluntary healthy males was performed by adding 10% CaCl2, thrombin, mixture CaCl2 + collagen type I. Blood derivatives were incubated for 15 30 minutes 1, 2, 24 hours samples evaluated release VEGF, TGF-β1, PDGF-AB, IL-1β, TNF-α....
Background: Soccer is a highly demanding sport for the knee joint, and chondral injuries can cause disabling symptoms that may jeopardize an athlete’s career. Articular cartilage lesions are difficult to treat, increased mechanical stress produced by this makes their management even more complex. Hypothesis: To evaluate whether regenerative cell-based approach allows these athletes better functional recovery compared with bone marrow stimulation approach. Study Design: Cohort study; Level of...
Background This study was undertaken to prospectively analyze, at a mean 11-year follow-up, the clinical and radiographic outcomes in patients undergoing authors’ intra-articular anterior cruciate ligament reconstructive procedure with extraarticular augmentation, compare these data those 5-year follow-up. Purpose The reconstruction were analyzed Study Design Case series; Level of evidence, 4. Methods authors studied 54 60 consecutive high-level sports who underwent their technique between...
Patellofemoral lesions represent a very troublesome condition to treat for orthopaedic surgeons; however, second-generation autologous chondrocyte implantation (ACI) seems offer an interesting treatment option with satisfactory results at short-term follow-up.Hyaluronan-based scaffold seeded chondrocytes is viable the damaged articular surface of patellofemoral joint.Case series; Level evidence, 4.Among group 38 patients treated full-thickness chondral ACI, we investigated 34 who were...
Objective: To compare the respective performance and effectiveness of autologous chondrocyte implantation (ACI) mosaicplasty at resurfacing local full-thickness chondral defects knee. Design: Randomized clinical trial. Setting: Multicenter trial orthopedic clinics university hospitals conducted from 1997 to 2000. Patients: A population patients selected according eligibility criteria age, traumatic origin defect, its localization, size, gravity, above all, no previous surgical treatment...
Abstract The objective of this article was to investigate the safety and regenerative potential a newly developed biomimetic scaffold when applied osteochondral defects in an animal model. A new multilayer gradient nano‐composite obtained by nucleating collagen fibrils with hydroxyapatite nanoparticles. In femoral condyles 12 sheep, 24 lesions were created. Animals randomized into three treatment groups: alone, colonized vitro autologous chondrocytes empty defects. Six months after surgery,...
Background: Loss of meniscal tissue can be responsible for increased pain and decreased function. Hypothesis: At a minimum 10-year follow-up, patients receiving medial collagen meniscus implant (MCMI) would show better clinical, radiological, magnetic resonance imaging (MRI) outcomes than treated with partial meniscectomy (PMM). Study Design: Cohort study; Level evidence 2. Methods: Thirty-three nonconsecutive (men; mean age, 40 years) injuries were enrolled in the study to receive MCMI or...