A5088393908- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Collagen: Extraction and Characterization
- Calcium Carbonate Crystallization and Inhibition
- Graphene and Nanomaterials Applications
- Orthopaedic implants and arthroplasty
- Tissue Engineering and Regenerative Medicine
- Dental Implant Techniques and Outcomes
- biodegradable polymer synthesis and properties
- Bone and Dental Protein Studies
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Nanoparticle-Based Drug Delivery
- Silk-based biomaterials and applications
- Spaceflight effects on biology
- Dental materials and restorations
- Carbohydrate Chemistry and Synthesis
- Orthopedic Infections and Treatments
- Mesenchymal stem cell research
- Cellular Mechanics and Interactions
- Bone Metabolism and Diseases
- Bone health and treatments
- Advanced Cellulose Research Studies
- Bone health and osteoporosis research
Institute of Science and Technology for Ceramics
2015-2024
National Research Council
2015-2024
Leipzig Heart Institute
2009-2023
National Academies of Sciences, Engineering, and Medicine
2007-2022
MRC Centre for Reproductive Health
2019
University of Edinburgh
2019
Ospedale per gli Infermi
2017
Materials and Energy Research Center
2015
Istituto Oncologico Romagnolo
2014
Istituto Ortopedico Rizzoli
2013
Replacement of bone tissue by graft materials and products engineering having composition, structure, biological features that mimic natural is a goal to be pursued. A biomimetic synthesis was performed prepare new bone-like composites constituted hydroxyapatite nanocrystals self-assembled type I collagen fibers. We used inspired approach proved the systems stored processed information at molecular level. Two different methodologies were used: dispersion synthetic in telopeptides free...
Abstract The objective of this article was to investigate the safety and regenerative potential a newly developed biomimetic scaffold when applied osteochondral defects in an animal model. A new multilayer gradient nano‐composite obtained by nucleating collagen fibrils with hydroxyapatite nanoparticles. In femoral condyles 12 sheep, 24 lesions were created. Animals randomized into three treatment groups: alone, colonized vitro autologous chondrocytes empty defects. Six months after surgery,...
In biomedicine, magnetic nanoparticles provide some attractive possibilities because they possess peculiar physical properties that permit their use in a wide range of applications. The concept guidance basically spans from drug delivery and hyperthermia treatment tumours, to tissue engineering, such as magneto-mechanical stimulation/activation cell constructs mechanosensitive ion channels, cell-seeding procedures, controlled proliferation differentiation. Accordingly, the aim this study was...
Augmentation of regenerative osteogenesis represents a premier clinical need, as hundreds thousands patients are left with insufficient healing bony defects related to host insults ranging from congenital abnormalities traumatic injury surgically-induced deficits. A synthetic material that closely mimics the composition and structure human osteogenic niche great potential successfully address this high demand. In study, magnesium-doped hydroxyapatite/type I collagen scaffold was fabricated...
Superparamagnetic nanoparticles (MNPs) have been progressively explored for their potential in biomedical applications and particular as a contrast agent diagnostic imaging, magnetic drug delivery more recently tissue engineering applications. Considering the importance of having safe MNPs such applications, essential role iron bone remodelling, this study developed analysed novel biocompatible bioreabsorbable superparamagnetic nanoparticles, that avoid use poorly tolerated magnetite based...
A bioinspired mineralization process was applied to develop biomimetic hybrid scaffolds made of (Fe2+/Fe3+)-doped hydroxyapatite nanocrystals nucleated on self-assembling collagen fibers and endowed with super-paramagnetic properties, minimizing the formation potentially cytotoxic magnetic phases such as magnetite or other iron oxide phases. Magnetic composites were prepared at different temperatures, effect this parameter reaction yield in terms degree, morphology, degradation,...
In the past few years, researchers have focused on design and development of three-dimensional (3D) advanced scaffolds, which offer significant advantages in terms cell performance. The introduction magnetic features into scaffold technology could innovative opportunities to control populations within 3D microenvironments, with potential enhance their use tissue regeneration or cell-based analysis. present study, fully biodegradable nanocomposite scaffolds for bone engineering, consisting a...
In case of degenerative disease or lesion, bone tissue replacement and regeneration is an important clinical goal. particular, nowadays, critical size defects rely on the engineering scaffolds that are 3D structural supports, allowing cellular infiltration subsequent integration with native tissue. Several ceramic hydroxyapatite (HA) high porosity good osteointegration have been developed in past few decades but they not solved completely problems related to defects. present study we a novel...
Magnetic bio-hybrid porous scaffolds have been synthesized, nucleating nano-apatite in situ on self-assembling collagen, the presence of magnetite nano-particles. The magnetic phase acted as a sort cross-linking agent for inducing chemico-physical-mechanical stabilization material and allowing us to control porosity network scaffold. Gradients bio-mineralization magnetization were also developed osteochondral application.
Doping of biocompatible nanomaterials with magnetic phases is currently one the most promising strategies for development advanced biomaterials. However, especially in case iron-doped hydroxyapatites, it not clear if features come merely from phases/ions used as dopants or complex mechanisms involving interactions at nanoscale. Here, we report an extensive chemical-physical and investigation three hydroxyapatite nanocrystals doped different iron species containing small no amounts maghemite...
Abstract The failure of the osteosarcoma conventional therapies leads to growing need for novel therapeutic strategies. lack specificity Cancer Stem Cells (CSCs) population has been recently identified as main limitation in current therapies. Moreover, traditional two-dimensional (2D) vitro models, employed drug testing and screening well study cell molecular biology, are affected by a poor vitro-in vivo translation ability. To overcome these limitations, this work provides two tumour...
The design and fabrication of advanced biocompatible bioresorbable materials able to mimic the natural tissues present in human body constitutes an important challenge regenerative medicine. size-dependent properties that exhibit at nanoscale as a consequence their higher surface-to-volume ratio have opened wide range opportunities for applications almost every imaginable field. In this regard, incorporation magnetic nanoparticles (MNPs) into scaffold formulations provides final with...