A5102725118- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Phytochemicals and Antioxidant Activities
- Phytochemical compounds biological activities
- Ginger and Zingiberaceae research
- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
- Bioactive natural compounds
- Phytochemistry and Bioactivity Studies
- Biological and pharmacological studies of plants
- Chemotherapy-induced organ toxicity mitigation
- Biological Activity of Diterpenoids and Biflavonoids
- Traditional and Medicinal Uses of Annonaceae
- Ginseng Biological Effects and Applications
- Inflammatory mediators and NSAID effects
- Postharvest Quality and Shelf Life Management
- Cancer, Lipids, and Metabolism
- Plant Stress Responses and Tolerance
- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
- Peroxisome Proliferator-Activated Receptors
- Medicinal Plants and Bioactive Compounds
- Plant Molecular Biology Research
- Plant tissue culture and regeneration
Asia University
2021-2025
China Medical University
2016-2025
National Yang Ming Chiao Tung University
2004-2023
Guangzhou University of Chinese Medicine
2017-2018
China Medical University Hospital
2015
Institute of Plant and Microbial Biology, Academia Sinica
2007-2008
Chang Gung University
2008
Chinese Culture University
2007
National Academy of Sciences of Ukraine
2004
The anti-inflammatory effect of hispolon has identified it as one the most important compounds from Sanghuangporus sanghuang. research objectives were to study this compound using an animal model by lipopolysaccharide (LPS)-induced acute lung injury. Hispolon treatment reduced production pro-inflammatory mediator NO, TNF-α, IL-1β, and IL-6 induced LPS challenge in tissues, well decreasing their histological alterations protein content. Total cell number was also bronchoalveolar lavage fluid...
Asiatic acid (AA), a pentacyclic triterpene compound in the medicinal plant Centella asiatica, was evaluated for antinociceptive and anti-inflammatory effects. Treatment of male ICR mice with AA significantly inhibited numbers acetic acid-induced writhing responses formalin-induced pain late phase. In test, decreased paw edema at 4th 5th h after λ-carrageenan (Carr) administration increased activities catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) liver tissue....
Acetaminophen (APAP) overdose is one of the most common causes drug-induced acute liver failure in humans. To investigate hepatoprotective effect salvianolic acid C (SAC) on APAP-induced hepatic damage, SAC was administered by daily intraperitoneal (i.p.) injection for 6 days before APAP administration mice. prevented elevation serum biochemical parameters and lipid profile including aspartate aminotransferase (AST), alanine (ALT), total bilirubin (T-Bil), cholesterol (TC), triacylglycerol...
Acute kidney injury (AKI) is a common clinical problem, characterized by sudden loss of renal function, high risk death, and the eventual development fibrosis failure. Cordyceps cicadae traditional Chinese medicine with potential function protection. We analyze two sputum extracts, water extract (WCC), an ethanol (ECC), to assess treating AKI in animal model induced cisplatin. A nephrotoxic mouse was first established intraperitoneal injection Subsequently, WCC ECC were orally administered...
The anti-inflammatory effect of ginsenoside Rh2 (GRh2) has labeled it as one the most important ginsenosides. purpose this study was to identify and antioxidant effects GRh2 using a lipopolysaccharide (LPS) challenge lung-injury animal model. reduced LPS-induced proinflammatory mediator nitric oxide (NO), tumor necrosis factor-alpha, interleukin (IL)-1β, cytokines (IL-4, IL-6, IL-10) production in lung tissues. treatment decreased histological alterations tissues bronchoalveolar lavage fluid...
Inotilone was isolated from Phellinus linteus. The anti-inflammatory effects of inotilone were studied by using lipopolysaccharide (LPS)-stimulated mouse macrophage RAW264.7 cells and λ-carrageenan (Carr)-induced hind paw edema model. tested for its ability to reduce nitric oxide (NO) production, the inducible synthase (iNOS) expression. in inhibitor mitogen-activated protein kinase (MAPK) [extracellular signal-regulated (ERK), c-Jun NH2-terminal (JNK), p38], nuclear factor-κB (NF-κB),...
Green nanotechnology of six types carbon nanodots (CNDs), and their sourcing from abundant natural plants, herbs, agriculture waste, provides a cost-effective method, with low cytotoxicity stable fluorescence, for biolabeling developing cell nanocarriers.
Idiopathic pulmonary fibrosis (IPF) is a type of interstitial pneumonia characterized by chronic and progressive with an unknown etiology. Previous pharmacological studies have shown that Sanghuangporus sanghuang possesses various beneficial properties including immunomodulatory, hepatoprotective, antitumor, antidiabetic, anti-inflammatory, neuroprotective effects. This study used bleomycin (BLM)-induced IPF mouse model to illustrate the possible benefits SS in ameliorating IPF. BLM was...
Hispolon, an active ingredient in the fungi Phellinus linteus was evaluated with analgesic and anti-inflammatory effects. Treatment of male ICR mice hispolon (10 20 mg/kg) significantly inhibited numbers acetic acid-induced writhing response. Also, our result showed that (20 formalin-induced pain later phase (P<.01). In test, decreased paw edema at fourth fifth hour after λ-carrageenin (Carr) administration, increased activities superoxide dismutase (SOD), glutathione peroxidase (GPx)...
Hispolon is an active phenolic compound of Phellinus igniarius , a mushroom that has recently been shown to have antioxidant, anti-inflammatory, and anticancer activities. This study investigated the antiproliferative effect hispolon on human hepatocellular carcinoma Hep3B cells by using MTT assay, DNA fragmentation, DAPI (4,6-diamidino-2-phenylindole dihydrochloride) staining, flow cytometric analyses. inhibited cellular growth in time-dependent dose-dependent manner, through induction cell...
Hispolon (a phenolic compound isolated from Phellinus linteus) has been shown to possess strong antioxidant, anti-inflammatory, anticancer, and antidiabetic properties. In this study, we investigated the antiproliferative effect of hispolon on human hepatocellular carcinoma NB4 cells using MTT assay, DNA fragmentation, DAPI (4, 6-diamidino-2-phenylindole dihydrochloride) staining, flow cytometric analysis. inhibited cellular growth in a dose-dependent manner through induction cell cycle...
Acute lung injury (ALI) is characterized by inflammation of the tissue and oxidative caused excessive accumulation reactive oxygen species. Studies have suggested that anti-inflammatory or antioxidant agents could be used for treatment ALI with a good outcome. Therefore, our study aimed to test whether mycelium extract Sanghuangporus sanghuang (SS-1), believed exhibit properties, against inflammatory response associated lipopolysaccharides (LPS)-induced in mice investigate its possible...
<italic>Sanghuangporus sanghuang</italic>is a rare fungal species that grows on wild mulberry trees, and its yield is much lower than of valuable medicinal herbs.
Acute kidney injury (AKI) is a sudden reduction in activity and has high mortality rate. Salvianolic acid C (SAC), one of the main polyphenolic components Salvia miltiorrhiza, displays significant pharmacologically active effects. An animal model cisplatin-induced was used to study potential SAC improve AKI. First, administered intraperitoneally mice for 10 consecutive days, then cisplatin on day 7 establish nephrotoxicity mouse model. mitigated renal histological changes, blood creatinine...