Lonicera japonica (Caprifoliaceae) has been known as an anti-inflammatory herb in traditional Chinese medicine for thousands of years and is used constantly upper respiratory tract infections. Luteolin, active flavonoid compound isolated from japonica, a spectrum biological activities, especially with antioxidative properties. However, whether luteolin direct inhibitory effect on lung fibrosis not established. In this study, we examined the effects both vivo vitro. We found that oral...

Polygonum orientale L. (Polygonaceae) fruits have various medicinal uses, but their hepatoprotective effects not yet been studied. This study investigated the activity of ethanolic extract P. (POE) against carbon tetrachloride (CCl4)-induced acute liver injury (ALI). Mice were pretreated with POE (0.1, 0.5, and 1.0 g/kg) or silymarin (0.2 for 5 consecutive days administered a dose 0.175% CCl4 (ip) on 5th day to induce ALI. Blood samples collected measure antioxidative cytokines. The...

Hispolon, an active ingredient in the fungi Phellinus linteus was evaluated with analgesic and anti-inflammatory effects. Treatment of male ICR mice hispolon (10 20 mg/kg) significantly inhibited numbers acetic acid-induced writhing response. Also, our result showed that (20 formalin-induced pain later phase (P<.01). In test, decreased paw edema at fourth fifth hour after λ-carrageenin (Carr) administration, increased activities superoxide dismutase (SOD), glutathione peroxidase (GPx)...

The effect of oral administration Phyllanthus methanolic extracts (PME) (i.e. P. acidus, emblica, myrtifolius, multiflorus, amarus, debilis, embergeri, hookeri, tenellus, urinaria L.s. nudicarpus, urinaria) or gallic acid (GA) on the progression acute liver damage induced by CCl 4 in rats was examined morphological and biochemical methods. urinaria, GA at a dose 0.5 g/kg, nudicarpus 1.0 g/kg attenuated -induced increase serum glutamate-oxalate-transaminase (GOT). tenellus...

The aims of this study intended to investigate the anti-inflammatory activity 70% ethanol extract from Scoparia dulcis (SDE) and betulinic acid on λ-carrageenan-induced paw edema in mice. mechanism SDE was examined by detecting levels cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β) malondialdehyde (MDA) tissue activities superoxide dismutase (SOD), glutathione peroxidase (GPx) reductase (GRd) liver. content detected high performance liquid...

Plectranthus amboinicus (Lour.) Spreng. is a native Labiatae plant of Taiwan. The plants are commonly used in Chinese folk medicine for the treatment cough, fever, sore throats, mumps, and mosquito bite. aim this study was to investigate analgesic antiinflammatory properties aqueous extract from (PA) vivo vitro. PA inhibited pain induced by acetic acid formalin, inflammation carrageenan. anti-inflammatory effect related modulating antioxidant enzymes' activities liver decreasing...

This study attempted to access the neuroprotective effect of diosgenin on senescent mice induced by d-galactose (D-gal). The in experiments were orally administered with (1, 5, 25 and 125 mg/kg), for four weeks from sixth week. learning memory abilities Morris water maze test mechanism involved brain tissue investigated. Diosgenin (5, mg/kg, p.o.) showed significantly improved compared D-gal treated (200 ten weeks). also increased activities superoxide dismutase (SOD) glutathione peroxidase...

The seeds of Cuscuta chinensis, Cuscutae Semen, are commonly used as a medicinal material for treating the aching and weakness loins knees, tonifying defects liver kidney, diarrhea due to hypofunction kidney spleen. Since inflammation highly correlated with such diseases, aim this study is investigate possible antinociceptive anti-inflammatory mechanisms C. chinensis. effect chinensis was evaluated via acetic acid-induced writhing response formalin-induced paw licking methods. λ-carrageenan...

Ameliorating effects were investigated of the cognitive-enhancing Chinese herbs administered orally for 1 week—Panax ginseng (PG), Panax notoginseng (PNG), Dioscorea opposita (DO), Gastrodia elata (GE), Salvia miltiorrhiza (SM), Acorus gramineus (AG), Coptis chinensis (CC), Polygonum multiflorum (PM), Cyperus rotundus (CR) and Psoralea corylifolia (PC)—on scopolamine (SCOP)-induced amnesia by using a passive avoidance task in rats. Of ten herbs, only PG, PNG, GE CC prolonged SCOP-shortened...

The present study was carried out to investigate the neuroprotective effect of luteolin on amyloid beta (Abeta) (25-35)-induced neurotoxicity using cultured rat cortical neurons. After exposure primary cultures cells 10 muM Abeta (25-35) for 48 h, cell exhibited marked apoptotic death. Pretreatment with (1, microM) significantly protected against toxicity. Luteolin showed a concentration-dependent inhibition neuronal death, as assessed by MTT assay. Furthermore, reduced characteristics DAPI...

In this study, we evaluated the analgesic effect of methanol extract from Desmodium triflorum DC (MDT) by using animal models acetic acid-induced writhing response and formalin test. The anti-inflammatory MDT was investigated λ-carrageenan-induced paw edema in mice. order to study mechanism MDT, detected activities glutathione peroxidase (GPx) reductase (GRd) liver, levels interleukin-1β (IL-1β), tumor necrosis factor (TNF-α), malondialdehyde (MDA) nitric oxide (NO) tissue. test, (0.5 1.0...

The aim of this study was to evaluate pharmacological properties ethanol extracted from Mahonia oiwakensis Hayata stems (MOS(EtOH)). included antioxidant, analgesic, anti-inflammatory and hepatoprotective effects. protoberberine alkaloid content the MOS(EtOH) analyzed by high-performance liquid chromatography (HPLC). results revealed that three alkaloids, berberine, palmatine jatrorrhizine, could be identified. Moreover, exhibited antioxidative activity using DPPH assay (IC(50), 0.743...

Abstract Background The present study was undertaken to evaluate the anti-depressive activity of turmerone after one-week administration by using a mouse forced swimming test (FST) and tail suspension (TST). Methods Animals were divided into four groups (n = 10 /group): control (0.9% saline), three doses (1.25, 2.5, 5.0 mg/kg) for treatment. To assess effect on locomotor activity, mice evaluated in open-field paradigm. Forced Tail (TST) used take as measure antidepressant activity. probable...

Coreopsis tinctoria is a traditional remedy for the management of various diseases including hepatitis. The hepatoprotective role plant not scientifically explored till now. This study was designed to investigate potentials ethanol extract from C. (CTEtOH) using an animal model carbon tetrachloride (CCl4)-induced acute liver injury.CTEtOH (0.5 and 1.0 g/kg) silymarin (200 mg/kg) were administered experimental mice 7 days followed by 0.2% CCl4 (10 mL/kg body weight (bw), ip), then all...

Objective: To investigate the hepatoprotective mechanisms of taxifolin in mice with acute liver injury induced by CCl4. Methods: ICR (Institute Cancer research) were orally pretreated using for 7 consecutive days and then given single intraperitoneal (i.p.) injections 0.2% CCl4 (10 mL/kg body weight, i.p.). Liver was determined assays serum alanine aminotransferase (sALT) aspartate (sAST). Further, to taxifolin, we malondialdehyde (MDA) levels superoxide dismutase (SOD), glutathione...

The global depression population is showing a significant increase. Hemerocallis fulva L. common Traditional Chinese Medicine (TCM). Its flower buds are known to have ability clear away heat and dampness, detoxify, relieve depression. Ancient TCM literature shows that its roots beneficial effect in calming the spirit even temper order reduce feeling of melancholy. Therefore, it inferred root can be used as therapeutic medicine for This study aims uncover pharmacological mechanism...