A5088248570- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Brucella: diagnosis, epidemiology, treatment
- Salmonella and Campylobacter epidemiology
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Diphtheria, Corynebacterium, and Tetanus
- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Poxvirus research and outbreaks
- Viral Infections and Vectors
- Infectious Diseases and Mycology
- Orthopedic Infections and Treatments
- Escherichia coli research studies
- Animal Virus Infections Studies
- Clostridium difficile and Clostridium perfringens research
- Burkholderia infections and melioidosis
- Transgenic Plants and Applications
- Childhood Cancer Survivors' Quality of Life
- Curcumin's Biomedical Applications
- COVID-19 Impact on Reproduction
- Muscle and Compartmental Disorders
Jawaharlal Institute of Post Graduate Medical Education and Research
2025
Indian Veterinary Research Institute
2020-2024
Indian Council of Medical Research
2023
In modern drug discovery, molecular docking analysis is routinely used to understand and predict the interaction between a molecule target protein from microbe. Drugs identified in this way may inhibit entry replication of pathogens host cells. The SARS-CoV-2 associated coronavirus disease, COVID-19, has become most contagious deadly pandemic disease world today. abeyance any specific vaccine or therapeutic against SARS-CoV-2, burgeoning situation urges need for effective drugs treat...
Brucellosis poses a significant burden to human and animal health worldwide. Robust harmonized molecular epidemiological approaches population studies that include routine disease screening are needed efficiently track the origin spread of Brucella strains. Core genome multilocus sequence typing (cgMLST) is powerful genotyping system commonly used delineate pathogen transmission routes for surveillance control. Except melitensis, cgMLST schemes species currently not established. Here, we...
Abstract Interaction of SARS-CoV-2 spike glycoprotein with the ACE2 cell receptor is very crucial for virus attachment to human cells. Selected mutations in S-protein are reported strengthen its binding affinity mammalian ACE2. The N501T mutation SARS-CoV-2-CTD furnishes better support hotspot 353 comparison SARS-CoV and shows higher binding. Recombination analysis exhibited recombination events strains, irrespective their geographical origin or hosts. Investigation further supports a common...
Since the beginning of New Year 2020, countries around world are stumbling due to coronavirus disease (COVID-19) pandemic. Better approaches diagnostics and medical facilities have helped some recover early. Previous exposures epidemics imparted lessons handle such a pandemic with high level preparedness. The World Health Organization (WHO) national health authorities taking great efforts via efficient impactful interventions contain virus. Diagnostic tests as reverse...
Brucella melitensis causes small ruminant brucellosis and a zoonotic pathogen prevalent worldwide. Whole genome phylogeny of all available B. genomes ( n = 355) revealed that Indian isolates 16) clustered in the East Mediterranean lineage except ADMAS-GI strain. Pangenome analysis indicated presence limited accessory with few clades showing specific gene presence/absence pattern. A total 43 virulence genes were predicted strains 2007BM-1 ricA wbkA are absent). Multilocus sequence typing...
Clostridium septicum is a Gram-positive, toxin-producing, and spore-forming bacterium that recognized, together with C. perfringens, as the most important etiologic agent of progressive gas gangrene. infections are almost always fatal in humans animals. Despite its clinical agricultural relevance, there currently limited knowledge diversity genome structure septicum. This study presents complete sequence DSM 7534T type strain well first comparative analysis five genomes. The taxonomy...
Experimental animal models are mostly vertebrate animals used as living simulations to study human and diseases learn host-pathogen interaction, underlying mechanisms of biological systems for its functioning, understand pathogenesis finally find appropriate remedies sufferings. These experimental in biomedical research is immense helping the creation world's first vaccine, which turn helped eradication smallpox. Thereafter number studies with monkeys, dogs, mice led development polio...
Mycobacterium orygis, a member of MTBC has been identified in higher numbers the recent years from animals South Asia. Comparative genomics this important zoonotic pathogen is not available which can provide data on molecular difference between other members. Hence, present study was carried out to isolate, whole genome sequence M. orygis different animal species (cattle, buffalo and deer) identify marker for differentiation Isolation sequencing 9 samples (4 cattle, 4 deer 1 buffalo) died...
An opportunistic pathogen, Trueperella pyogenes can infect cattle, buffalo, pig, goat, cat, dog, forest musk deer, etc., affecting various organs. The aim of this study was to identify the multidrug resistance genomic islands T. genomes available in NCBI database and also recently isolated strain TN_CUL_2020.The TN_CUL_2020 from swine lung abscess sequenced by Illumina platform, all genome retrieved for comparative analysis. ABRicate searches used antimicrobial genes, (GIs) were predicted...
Capture myopathy appears primarily when wild animals are captured. The important signs of CM an enormous increase in body temperature, muscle spasms, stiffness lameness, recumbent, the appearance dark red colored urine and finally, ends with Death. Large muscles hind limb affected commonly. It is very difficult to treat once clinical become apparent. condition carries a grave prognosis. Apart from wildlife, domestic humans also by these conditions similar pathophysiology. This review aims...
ABSTRACT We isolated and characterized two lytic bacteriophages against Staphylococcus aureus named TANUVAS_MVC-VPHSA1 TANUVAS_MVC-VPHSA2, with the aim of investigating their genomic structural features. The belong to Caudoviricetes, genomes have sizes 50,505 50,516 base pairs a GC content 41.4%.
Capripoxvirus, a member of the poxviridae family causes three economically important diseases in ruminants namely, lumpy skin disease (LSD) cattle, sheeppox sheep, and goatpox goats. Albeit non-zoonotic nature, they have potential to cause high economic loss among farmers. Capripoxvirus members share common structural proteins can rise cross-immunity them. The present study aimed design recombinant chimeric vaccine from immunogenic these protect all host species by using immunoinformatics...