A5113648321- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Surfactants and Colloidal Systems
- Nanoparticle-Based Drug Delivery
- Pharmaceutical studies and practices
- Thermodynamic properties of mixtures
- Inhalation and Respiratory Drug Delivery
- RNA Interference and Gene Delivery
- Protein purification and stability
- Gastrointestinal motility and disorders
- Analytical Chemistry and Chromatography
- Polymer Surface Interaction Studies
- Clinical Nutrition and Gastroenterology
- Lipid Membrane Structure and Behavior
- Electrostatics and Colloid Interactions
- Antibiotics Pharmacokinetics and Efficacy
- Rheology and Fluid Dynamics Studies
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- biodegradable polymer synthesis and properties
- Gastroesophageal reflux and treatments
- Protein Interaction Studies and Fluorescence Analysis
- Spectroscopy and Quantum Chemical Studies
- Advanced Polymer Synthesis and Characterization
- Chemical and Physical Properties in Aqueous Solutions
University of Nottingham
1996-2012
West Pharmaceutical Services (United Kingdom)
2001-2003
Syngenta (United Kingdom)
2002
AstraZeneca (United Kingdom)
2002
University of Surrey
1993-1995
University of Manchester
1993
Queen's Medical Centre
1979-1991
Merck & Co., Inc., Rahway, NJ, USA (United States)
1991
United States Military Academy
1991
Schools of Visual Arts, The Royal Danish Academy of Fine Arts
1982-1987
The gastrointestinal transit of pharmaceutical dosage forms has been measured in 201 studies normal subjects using gamma scintigraphy. Solutions, small pellets, and single units (matrix tablets osmotic pumps) were administered with different amounts food the stomach, ranging from fasted state to heavy breakfast. Gastric emptying was affected by nature form presence stomach. Solutions pellets emptied even when stomach digestive mode, while retained for long periods time, depending on size...
NMR studies on a series of poly(lactic acid)−poly(ethylene oxide) (PLA−PEG) diblock copolymers have been carried out in d6-acetone and D2O. Nanoparticles the PLA−PEG were obtained using modified interfacial polymer deposition−solvent evaporation technique (Fessi, H.; Devissaguet, J. P.; Puisieux, F.; Thies, C. French Patent 2 608 988, 1986). In D2O, PLA block forms central hydrophobic core, while PEG an hydrophilic corona layer. core nanoparticle is generally not seen, observed. Only methyl...
Human serum albumin (HSA) nanospheres of about 100 nm diameter were prepared using a pH-coacervation method whereby acetone was added to an HSA solution (pH 9.0). The particles obtained cross-linked by glutaraldehyde. Increasing the pH resulted in gradual rise particle size resultant nanospheres. A higher cross-linking efficiency with increased glutaraldehyde concentration and time. No significant differences surface properties, as determined zeta potential measurements, recorded between...
The concept of steric stabilization as used in colloid science is applied to carefully manipulate the drainage and lymphatic distribution subcutaneously administered model polystyrene nanospheres. A wide range synthetic polyoxyethylene (POE)/polyoxypropylene (POP) block co‐polymers poloxamine poloxamer series have been produce sterically stabilized We found a correlation between length stabilizing POE chains copolymers nanosphere passageway across tissue lymph interface dermal capillaries...
Atomic force microscopy has been utilized to probe, at a molecular level, the interaction between purified pig gastric mucin (PGM) and mucoadhesive cationic polymer, chitosan (sea cure 210+), with low degree (approx. 11%) of acetylation. Images were produced detailing structures both PGM in 0.1 M acetate buffer (pH 4.5), followed by complex two same buffer. revealed long linear filamentous structures, consistent earlier electron scanning tunnelling micoscopy studies. The molecules also...