A5032110952- Silk-based biomaterials and applications
- Conducting polymers and applications
- Electrospun Nanofibers in Biomedical Applications
- Neuroscience and Neural Engineering
- Supramolecular Self-Assembly in Materials
- Drug Solubulity and Delivery Systems
- Bone Tissue Engineering Materials
- Gastroesophageal reflux and treatments
- Advanced Sensor and Energy Harvesting Materials
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Pharmaceutical studies and practices
- Radiopharmaceutical Chemistry and Applications
- RNA Interference and Gene Delivery
- Interactive and Immersive Displays
- Hydrogels: synthesis, properties, applications
- Inhalation and Respiratory Drug Delivery
- Biochemical and Structural Characterization
- Gastrointestinal motility and disorders
- Tactile and Sensory Interactions
- Medical Imaging Techniques and Applications
- Nerve injury and regeneration
- Dendrimers and Hyperbranched Polymers
- Advanced Drug Delivery Systems
- Advanced biosensing and bioanalysis techniques
Lancaster University
2016-2025
Instituto de Ciencia de Materiales de Sevilla
2020-2025
Northern Arizona University
2025
Norfolk and Suffolk NHS Foundation Trust
2024
Lancaster City Council
2020-2021
University of Florida
2014-2020
The University of Texas at Austin
2013-2020
University of Bristol
2004-2019
University of York
2004-2019
University of Bayreuth
2008-2018
The gastrointestinal transit of pharmaceutical dosage forms has been measured in 201 studies normal subjects using gamma scintigraphy. Solutions, small pellets, and single units (matrix tablets osmotic pumps) were administered with different amounts food the stomach, ranging from fasted state to heavy breakfast. Gastric emptying was affected by nature form presence stomach. Solutions pellets emptied even when stomach digestive mode, while retained for long periods time, depending on size...
A sacrificial templating process using lithographically printed minimal surface structures allows complex de novo geometries of delicate hydrogel materials. The scaffolds based on cellulose and chitin nanofibrils show differences in terms attachment human mesenchymal stem cells, allow their differentiation into osteogenic outcomes. approach here serves as a first example toward designer viable for biomimetic tissue engineering. As service to our authors readers, this journal provides...
Abstract The transits of a capsule and multiparticulate pellet system have been monitored through the gastrointestinal tract in six healthy volunteers. Both preparations moved together stomach small intestine, reaching colon, on average, 4 h after dosing. Within colon pellets dispersed at slower rate than capsule. There was considerable intersubject variability large bowel transit times. findings are discussed terms drug delivery to colon.
Shape‐memory polymers (SMPs) are morphologically responsive materials with potential for a variety of biomedical applications, particularly as devices minimally invasive surgery and the delivery therapeutics cells tissue engineering. A brief introduction to SMPs is followed by discussion current progress toward development SMP‐based biomaterials clinically relevant applications.
We describe, for the first time, stimulus-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically relevant model drug (ibuprofen) upon application light. MN were prepared using polymer from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained showed good mechanical properties. system was loaded with up to 5% (w/w) ibuprofen included in light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy...
Alzheimer's disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides, which are generated from amyloid precursor protein (APP) β- and γ-secretases. APP the secretases membrane associated, but whether trafficking controls Aβ levels unclear. Here, we performed an RNAi screen all human Rab-GTPases, regulate trafficking, complemented with a Rab-GTPase-activating screen, present road map membrane-trafficking events regulating production. We identify Rab11 Rab3 as key...
Visualizations such as bar charts help users reason about data, but are mostly screen-based, rarely physical, and almost never physical dynamic. This paper investigates the role of physically dynamic evaluates new interactions for exploring working with datasets rendered in form. To facilitate our exploration we constructed a 10x10 interactive chart designed that supported fundamental visualisation tasks, specifically; annotation, filtering, organization, navigation. The were evaluated user...
Burn injuries have been reported to be an important cause of morbidity and mortality they are still considered as unmet clinical need. Although there is a myriad effective stem cells that suggested for skin regeneration, no one ideal scaffold. The aim this study was develop three-dimensional (3D) bi-layer scaffold made biological decellularized human amniotic membrane (AM) with viscoelastic electrospun nanofibrous silk fibroin (ESF) spun on top. fabricated 3D AM/ESF submerged in ethanol...
Conductive polymers (CPs) such as polypyrrole (PPY) are emerging biomaterials for use scaffolds and bioelectrodes which interact with biological systems electrically. Still, more electrically conductive biologically interactive CPs required to develop high performance medical devices. In this study, in situ electrochemical copolymerization of polydopamine (PDA) PPY were performed electrode modification. Their material properties characterized using multiple techniques. The electrical...
Electroactive hydrogels can be used to influence cell response and maturation by electrical stimulation. However, hydrogel formulations which are 3D printable, electroactive, cytocompatible, allow adhesion, remain a challenge in the design of such stimuli-responsive biomaterials for tissue engineering. Here, combination pyrrole with high gelatin-content oxidized alginate-gelatin (ADA-GEL) is reported, offering 3D-printability precursors prepare cytocompatible electrically conductive...