Abstract This article reports a new process chain for custom‐made three‐dimensional (3D) porous ceramic scaffolds bone replacement with fully interconnected channel network the repair of osseous defects from trauma or disease. Rapid prototyping and especially 3D printing is well suited to generate complex‐shaped matrices directly powder materials. Anatomical information obtained patient can be used design implant target defect. In technique, box filled printed polymer‐based binder solution...

Part defects and irregularities that influence the part quality is an especially large problem in additive manufacturing (AM) processes such as selective laser sintering (SLS). Destructive non-destructive testing procedures are currently mostly used for control defect detection of AM parts after production. In this context, machine learning (ML) algorithms increasingly being to enable computer-aided through automatic classification data. Convolutional neural networks (CNN) based on ML...

Abstract Hydroxyapatite (HAP) and tricalcium phosphate (TCP) are two very common ceramic materials for bone replacement. However, in general HAP TCP scaffolds not tailored to the exact dimensions of defect site mainly used as granules or beads. Some available ordinary blocks, but cannot be customized individual perfect fit. Using computer‐assisted 3D printing, an emerging rapid prototyping technique, three‐dimensional can built up from powder layer by with subsequent sintering. These have...

Various biomaterials have been developed for the use as bone substitutes defects. To optimize their integration and functionality, they should be adapted to individual defect. Rapid prototyping is a manufacturing method tailor materials 3D geometry of Especially printing allows manufacture implants, shape which can designed fit defect using anatomical information obtained from patient. calcium phosphates, are well established substitutes, involves sintering step after gluing granules...

The prevalence of large bone defects is still a major problem in surgical clinics. It is, thus, not surprise that bone-related research, especially the field tissue engineering, issue medical research. Researchers worldwide are searching for missing link engineering graft materials mimic bones, and foster osteogenesis remodeling. One approach combination additive manufacturing technology with smart additionally electrically active biomaterials. In this study, we performed three-dimensional...

The treatment of critical size bone defects, for example resulting from large tumor resections, still remains a challenge in clinical practice. It has been demonstrated that the gold standard based on auto- and allografts can provide aid some cases. However, development patient specific 3D printed implants modern biomaterial-based tissue engineering (TE) strategies, avoiding requirement harvesting donor site, promises to be next generation healing. We present PLA-Bioactive glass (BG)...

Electroactive hydrogels can be used to influence cell response and maturation by electrical stimulation. However, hydrogel formulations which are 3D printable, electroactive, cytocompatible, allow adhesion, remain a challenge in the design of such stimuli-responsive biomaterials for tissue engineering. Here, combination pyrrole with high gelatin-content oxidized alginate-gelatin (ADA-GEL) is reported, offering 3D-printability precursors prepare cytocompatible electrically conductive...

Abstract Reconstruction of bone defects represents a serious issue for orthopaedic and maxillofacial surgeons, especially in extensive loss. Adipose-derived mesenchymal stem cells (ADSCs) with tri-calcium phosphates (TCP) are widely used regeneration facilitating the formation extracellular matrix to promote reparative osteogenesis. The present study assessed potential cell-scaffold constructs mandibular minipig model. Sixteen skeletally mature miniature pigs were divided into two groups:...

Surface structuring is a key factor for the tailoring of proper cell attachment and improvement bone-implant interface anchorage. Femtosecond laser machining especially suited to implants due possibility creating surfaces with wide variety nano- microstructures. To achieve desired surface topography, different parameters can be adjusted. The scanning strategy, or rather pulse overlap line overlap, affect topography in an essential way, which demonstrated this study. Ti6Al4V samples were...

Three-dimensional (3D) printing technology enables the design of personalized scaffolds with tunable pore size and composition.Combining decellularization 3D techniques provides opportunity to fabricate high potential mimic native tissue.The aim this study is produce novel decellularized bone extracellular matrix (dbECM)-reinforced composite-scaffold that can be used as a biomaterial for tissue engineering.Decellularized particles (dbPTs, ~100 μm diameter) were obtained from rabbit femur...

Bone healing is a complex process orchestrated by various factors, such as mechanical, chemical and electrical cues. Creating synthetic biomaterials that combine several of these factors leading to tailored controlled tissue regeneration, the goal scientists worldwide. Among those piezoelectricity which creates physiological microenvironment plays an important role in stimulating bone cells fostering regeneration. However, only limited number studies have addressed potential combining...

Purpose The purpose of this paper is to characterize and evaluate a new 3D‐printing process based on Poly(methyl methacrylate) (PMMA). Design/methodology/approach A benchmark part standard parts were designed, printed by 3D‐printer characterized. Findings 3D PMMA have tensile strength 2.91 MPa modulus elasticity 223 MPa. mechanical properties can be improved infiltrations with epoxy (tensile strength: 26.6 MPa, elasticity: 1,190 MPa). surface quality the infiltration wax for usage as lost...

The use of additive manufacturing technologies to produce lightweight or functional structures is widespread. Especially Ti6Al4V plays an important role in this development field and parts are manufactured analyzed with the aim characterize mechanical properties open-porous generate scaffolds specific their intended application. An SLM EBM process were used respectively fabricate single struts. For characterization, uniaxial compression tests hardness measurements conducted. Furthermore,...

The mechanical behavior of cartilage tissue plays a crucial role in physiological mechanotransduction processes chondrocytes and pathological changes like osteoarthritis. Therefore, intensive research activities focus on the identification implant substitute materials that mechanically mimic extracellular matrix. This, however, requires thorough understanding complex both native potential to treat lesions. Here, we perform multi-modal analyses human articular two surrogate materials,...

Composite Extrusion Modeling (CEM) is an advanced material extrusion additive manufacturing technique for low-cost rapid production of complex parts. In this work, a conventional Metal Injection Moulding (MIM) feedstock used 3D printing low alloy-steel AISI 8740 via CEM. This steel widely in aircraft, aerospace, and MIM industries. However, it has, so far, not been processed using CEM-based printing. The influence four parameters, multiplier, temperature, nozzle velocity, layer thickness on...

Composite Extrusion Modeling (CEM) is a screw-based material extrusion (MEX) additive manufacturing process that can produce plastic, metal and ceramic parts based on standard injection molding feedstocks. In this work, an aluminum oxide feedstock (Al2O3) originally developed for processed via MEX the first time by depositing plasticized in layers build platform. order to identify appropriate parameters, characterized estimate printable temperature processing window. Initially, best values...

The 3-D printing technique was used for the fabrication of HA, TCP and BCP ceramics influence granulate composition on printed scaffolds investigated. An optimal granulates found. Thus, individual implants can be manufactured via from different CaP phase compositions to tailor their degradation behavior osteoconductivity enhanced bone healing.

Nano- and microstructured titanium surfaces have recently attracted attention in the field of regenerative medicine because influence which surface characteristics such as roughness wettability can on cellular processes. This study focuses correlation properties (wettability nano/micro texture) laser-structured Ti6Al4V samples with pronounced cell adhesion. Samples were structured multiple laser parameters order to create a range properties. Surface characterization was performed by contact...

Additive manufactured porous biomaterials based on triply periodic minimal surfaces (TPMS) are a highly discussed topic in the literature. With their unique properties terms of open porosity, large surface area and curvature, they considered to have bone mimicking remarkable osteogenic potential. In this study, scaffolds gyroid unit cells different sizes consisting Ti6Al4V alloy were additively by electron beam melting (EBM). The analysed micro-computed tomography (micro-CT) determine...