A5101580088- Southeast Asian Sociopolitical Studies
- Asian Geopolitics and Ethnography
- Statistical Methods in Clinical Trials
- Ethics in Clinical Research
- Meta-analysis and systematic reviews
- Pharmaceutical studies and practices
- Corporate Governance and Management
- Respiratory and Cough-Related Research
- Gastrointestinal motility and disorders
- Translation Studies and Practices
- Economic and Financial Impacts of Cancer
- Adolescent Sexual and Reproductive Health
- Law and Political Science
- Pharmacovigilance and Adverse Drug Reactions
- Complementary and Alternative Medicine Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Diabetes Treatment and Management
- Phytochemical Studies and Bioactivities
- Organ and Tissue Transplantation Research
- Cerebrovascular and Carotid Artery Diseases
- Infrared Thermography in Medicine
- Breast Lesions and Carcinomas
- Place Attachment and Urban Studies
- Cardiovascular and Diving-Related Complications
- Heavy Metals in Plants
Wenzhou Medical University
2010-2024
First Affiliated Hospital of Wenzhou Medical University
2010-2024
Shandong First Medical University
2022-2023
Kunming Institute of Botany
2022
Affiliated Hospital of Taishan Medical University
2022
Sichuan University
2020
West China Second University Hospital of Sichuan University
2020
Taishan Medical University
2019
The objective of this study was to explore the impact coronavirus disease 2019 epidemic on ongoing and upcoming drug clinical trials. Qualitative semi-structured interviews were conducted with trial staff subjects surveyed by questionnaire in study. results showed that pandemic has led many changes implementation trials, including: a variety meetings being held online webinars using various platforms, telemedicine follow-up video, A large number deviations from protocol losses follow-up,...
Objectives: Early recanalization of large vessels in thromboembolism, such as myocardial infarction and ischemic stroke, is associated with improved clinical outcomes. Nitric oxide (NO), a biological gas signaling molecule, has been proven to protect against ischemia–reperfusion injury (IRI). However, the underlying mechanisms remain be explored. This study investigated whether NO could mitigate IRI role during acoustic cavitation. Methods: In vivo , thrombi iliac artery rats were induced by...
We studied the associations and correlations between premature ejaculation (PE) psychological disorders, such as anxiety depression, in new perspectives with an aim of improving PE patients' treatment outcomes. Between December 2017 2018, we selected 1,010 men aged over 18 years old. Self-estimated IELT, diagnostic tool, International Index Erectile Function-5, General Anxiety Disorder-7 Patients Health Questionnaire-9 were used to measure latency time, ejaculation, erectile dysfunction,...
The purpose of this study was to explore the effects CYP2C19 gene polymorphisms and various environmental factors their interactions on risk esophageal squamous cell carcinoma (ESCC) in a Chinese Han population.A 1:2 frequency-matched case control 285 patients 570 controls conducted from June 2010 May 2011 AnXi Fujian province, China. Environmental were investigated using self-administered questionnaire genotypes determined polymerase chain reaction restriction fragment length polymorphism...
Abstract The objective of the present study was to evaluate bioequivalence between generic and branded metformin extended‐release (ER) tablets in Chinese subjects. We tested vitro vivo using a comparative dissolution pharmacokinetic trial. Safety assessments were conducted throughout entire trial period. profiles formulation expressed obvious properties, similar those ( f 2 > 60.0%). Consistent with result study, no remarkable differences found terms formulations. 90% confidence intervals...
Abstract This study aimed to evaluate the bioequivalence of 2 amlodipine besylate tablet formulations, a generic formulation and an original formulation, investigate their pharmacokinetic safety profiles. was designed as randomized, open‐label, single‐dose, crossover, dual‐period divided into fasting postprandial human trials. In first trial after overnight fasting, 28 subjects were given 5‐mg tablets via oral administration, blood specimens obtained up 144 hours dosing; another had high‐fat...
The objectives of the present study were to evaluate bioequivalence 2 tablet formulations prucalopride, generic and branded, investigate relevant pharmacokinetic safety profiles. This was designed as a randomized, open-label, fasting, single-dose, crossover, dual-period trial. After overnight 12 subjects given prucalopride tablets via oral administration, blood specimens obtained up 96 hours after dosing. Prucalopride concentrations in plasma measured using ultraprecision liquid...
Abstract Objective The changes of absolute value and relative clinical research coordinator service fee its influence on the quality drug trial were analyzed. Methods This study compared amount structural costs in before 3 years after self-examination inspection initiated by China Food Drug Administration, identified increase number composition each individual cost a funds which including fee, investigator labor subjects examination traffic subsidy, documents management etc. Result most...
Arterial thrombotic disease is a common and serious clinical medical problem. Nitric oxide (NO), as therapeutic gas, can delay the progression of thrombosis reduce tissue ischemia hypoxia damage. However, systemic delivery NO causes complications, in body easily cleared by hemoglobin blood. In this study, we designed lipid microbubble carrying (NO-MBs) combined with ultrasound-targeted destruction (UTMD) technology to achieve targeted under real-time contrast-enhanced ultrasound monitoring....
Abstract This study aimed to evaluate the bioequivalence of 2 pantoprazole sodium enteric‐coated tablet formulations, a generic formulation and branded formulation, investigate their pharmacokinetic safety profiles. The was designed as single‐center, randomized, open‐label, single‐dose, dual‐period, 2‐sequence crossover trial, divided into fasting postprandial human trials. In first 36 subjects were fasted overnight before they given or tablets (during separate administration periods)....
Abstract Objective: The changes of absolute value and relative clinical research coordinator service fee its influence on the quality drug trial were analyzed.Methods: This study compared amount structural costs in before 3 years after self-examination inspection initiated by China Food Drug Administration, identified increase number composition each individual cost a funds which including fee, investigator labor subjects examination traffic subsidy, documents management etc.Result: most...
By studying the academia criterion of first hospital affiliated wenzhou medical univertisy full-time graduate,result display that part graduate student academic consciousness is faint,lack related knowledge,academic anomie behavior sometimes appear,Supervisor partly absent from guide.Aiming at this situation,University should strengthen education Supervisor,improve system rewards and punishment,purify atmosphere,promote degree criterion. Key words: Graduate; Academia criterion; ...