A5100461827- Pharmacogenetics and Drug Metabolism
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Medicinal Plant Pharmacodynamics Research
- Cancer therapeutics and mechanisms
- Cell Image Analysis Techniques
- Drug-Induced Hepatotoxicity and Protection
- Lung Cancer Research Studies
- Nuclear Receptors and Signaling
- Cancer Research and Treatments
- Computational Drug Discovery Methods
- Neuroendocrine Tumor Research Advances
- Natural product bioactivities and synthesis
- Plant-based Medicinal Research
- Bioactive Natural Diterpenoids Research
- Synthesis and Biological Evaluation
- Dermatology and Skin Diseases
- Bioactive Compounds and Antitumor Agents
- Click Chemistry and Applications
- Vitamin K Research Studies
- RNA regulation and disease
- Phytoestrogen effects and research
- Drug Transport and Resistance Mechanisms
- Peptidase Inhibition and Analysis
- Traditional Chinese Medicine Analysis
University of Maryland, Baltimore
2019-2025
Peking University First Hospital
2018-2025
Peking University
2018-2025
Sichuan University
2022
West China Hospital of Sichuan University
2022
Shandong University of Traditional Chinese Medicine
2021
Harbin Medical University
2021
Guangdong Pharmaceutical University
2018
The constitutive androstane receptor (CAR) is a nuclear that plays crucial role in regulating xenobiotic metabolism and detoxification, energy homeostasis, cell proliferation by modulating the transcription of numerous target genes. CAR activation has been established as mode action which phenobarbital-like nongenotoxic carcinogens promote liver tumor formation rodents. This paradigm, however, appears to be unrelated function human (hCAR) hepatocellular carcinoma (HCC), remains poorly...
Phenobarbital (PB), a broadly used antiseizure drug, was the first to be characterized as an inducer of cytochrome P450 by activation constitutive androstane receptor (CAR). Although PB is recognized conserved CAR activator among species via well-documented indirect mechanism, conflicting results have been reported regarding regulation pregnane X (PXR), sister CAR, and underlying mechanisms remain elusive. Here, we show that in human (hCAR)-knockout (KO) HepaRG cell line, significantly...
Enhancement of the metabolic conversion cyclophosphamide (CPA) increases its therapeutic effects. Activation human constitutive androstane receptor (hCAR) induces CYP2B6, a key enzyme responsible for CPA bioactivation. Based on our previous hCAR activator DL5016, we designed and synthesized series new activators. Compared to three compounds 6i, 6k (DL5055), 7e, showed significantly improved activating potency hCAR. Particularly, DL5055 activates with an EC50 0.35 μM EMAX 4.3, does not...
Gastrin-releasing peptide precursor (ProGRP) is a bioactive of GRP and might play an important role as emerging tumor marker in early cancer diagnosis. It also be abnormal the nonmalignant disease renal function abnormalities. The present study was undertaken to investigate changes ProGRP levels patients with kidney injuries, especially chronic (CKD), determine upper reference intervals clinical diagnostic value CKD, thus help oncologists interpreting making judgments malignances. 676...
Phenobarbital (PB), a widely used antiepileptic drug, is known to upregulate the expression of numerous drug-metabolizing enzymes and transporters in liver primarily via activation constitutive androstane receptor (CAR, NR1I3). The solute carrier family 13 member 5 (SLC13A5), sodium-coupled citrate transporter, plays an important role intracellular homeostasis that associated with number metabolic syndromes neurological disorders. Here, we show PB markedly elevates SLC13A5 through pregnane X...
The present study was designed to investigate the effect of FPZ, a total flavonoids ointment topical application from Pouzolzia zeylanica var. microphylla (Wedd.) Masam, Urticaceae, on skin infections in mice. FPZ anti-infective investigated Staphylococcus aureus-induced abscess and ulcers mice by evaluating variation volume, histopathology tissue healing rate. Secondary, it is anti-inflammatory activities carrageenan-induced hind paw edema estimated. Besides, fingerprint performed using...
The aim of the present study was to investigate protective effect hypaconitine on apoptosis induced by H2O2 and underlying molecular mechanism in cardiac myocytes. First, myocytes were pretreated with different concentrations (0, 62.5, 125, and 250 ng/ml) before exposure 100 µM H2O2. Cell viability, apoptosis, activation caspase-3 -9, p38 mitogen-activated protein kinases (MAPK), nuclear factor κB (NF-κB) p65 examined. In our study, H2O2 treatment resulted a dose-dependent increase number...
Background. More than a third of women could develop ovarian cysts during their lifetime. Jingshu granules are used for the treatment gynecological disease primary dysmenorrhea. However, molecular mechanisms in still unreported. We aimed to find active ingredients, targets, and potential signaling pathways by using systemic pharmacological analysis. Methods. Firstly, effect on female hormones reproductive organs young rats was evaluated. Secondly, candidate pharmaceutical ingredients were...
Abstract Parkinson's disease (PD) is the second most common neurodegenerative disease. The pathogenesis of PD remains elusive, however appears to be caused by a complex interaction between environmental and genetic factors affecting various biological processes. purpose present study identify hub genes potential molecular mechanisms in peripheral blood mononuclear cells (PBMCs) patients aid early diagnosis start treatment promptly. Two gene expression profiles (GSE22491 GSE100054) were...