A5001980994- Diet and metabolism studies
- Eicosanoids and Hypertension Pharmacology
- Fatty Acid Research and Health
- Bone fractures and treatments
- Trypanosoma species research and implications
- Alcohol Consumption and Health Effects
- Heavy Metals in Plants
- Diet, Metabolism, and Disease
- Cancer, Lipids, and Metabolism
- Cannabis and Cannabinoid Research
- Medical and Biological Sciences
- Sirtuins and Resveratrol in Medicine
- Sodium Intake and Health
- Health and Lifestyle Studies
- Ginkgo biloba and Cashew Applications
- Bone Tumor Diagnosis and Treatments
- Neurological Disease Mechanisms and Treatments
- Orthopedic Surgery and Rehabilitation
- Adipose Tissue and Metabolism
- Retinal Diseases and Treatments
- Diabetes and associated disorders
- Alkaline Phosphatase Research Studies
- Retinal Imaging and Analysis
- Salivary Gland Disorders and Functions
- Tumors and Oncological Cases
Consejo Nacional de Investigaciones Científicas y Técnicas
2013-2022
Universidad Nacional de Córdoba
2013-2022
Instituto de Investigaciones en Ciencias de la Salud
2013-2022
Instituto de Biología Molecular y Celular de Rosario
2017-2018
National University of La Rioja
2011-2015
Centro Científico Tecnológico - Córdoba
2015
Centro Científico Tecnológico - San Juan
2009
Diabetic encephalopathy is a chronic complications of diabetes mellitus that affects the central nervous system. We evaluated effect ω3 and ω6 polyunsaturated fatty acids (PUFAs) supplementation plus antioxidant agent nordihydroguaiaretic acid (NDGA) on etiopathology diabetic in eSS rats, spontaneous model type 2 diabetes. One hundred twenty male rats 38 non-diabetic Wistar, used as healthy control, received monthly by intraperitoneal route, or PUFA (6.25 mg/kg) alone NDGA (1.19 for 12...
Lung carcinoma is one of the most common cancers and has a high mortality. Recently, we showed that it produces neurological paraneoplastic syndrome, with Ilex paraguariensis (IP) extract exerting palliative effects due to its content phenolic compounds. It possible, therefore, these diet agents can arrive at brain exert neuroprotection, after oral intake IP. Here, aim was investigate protective role bioavailable IP compounds on telencephalon diencephalon in lung adenocarcinoma‐bearing...
Diabetes mellitus (DM) is a complex disease with alterations in metabolic and inflammatory markers. Stillman Salgado rats (eSS) spontaneously develop type 2 DM by middle age showing progressive impairment of glucose tolerance hyperglycemia, hypertriglyceridemia hyperinsulinemia. We analyzed the effects supplementation ω-3 ω-6 polyunsaturated fatty acids (PUFAs) or without nordihydroguaiaretic acid (NDGA) added, an antioxidant lipoxygenase inhibitor, on parameters eSS to evaluate whether they...
Dietary phenolic compounds are plant metabolites with beneficial effects on the central nervous system. Thus, our aim was to identify anti-inflammatory from South American plants glia, which regulates neuro-immune response. The were extracted Lantana grisebachii (LG), Aspidosperma quebracho-blanco (AQB), and Ilex paraguariensis (IP) teas identified by HPLC-DAD-MS. Extracts (0–200 µg/ml) tested human T98-G rat C6 glioma lines. Cellular viability (by resazurin assay), fatty acid profile gas...
Ilex paraguariensis (IP) is widely consumed as tea with high nutritional value. This plant contains several bioactive phenolic compounds, which are antioxidant and anti-inflammatory. On the other hand, lung adenocarcinoma (LAC) deleteriously involves neoplastic progression, inflammatory paraneoplastic syndromes, death. Given that brain a frequent target of this illness, our objective was to determine neuroprotective effect IP consumption in LAC-bearing mice. They were orally treated 50 mg...
The amount and type of dietary fats represent risk factors for several cancers. Essential PUFAs serve as precursors biologically active molecules, mainly endocannabinoids eicosanoids, which participate in tumorigenic processes. However, their mechanisms still remain unclear. This article reviews the current knowledge experimental results on effects manipulation n-3, n-6 essential fatty acids (EFA) including conjugated linoleic acid (CLA), eicosanoid endocannabinoid production, correlation...
The essential PUFAs (polyunsaturated fatty acids) serve as precursors of several bioactive lipids molecules including the endocannabinoids (ECS). This article reviews components endocannabinoid system, and their functions. Furthermore, a brief overview on relationship this system with some physiological pathological processes, focus metabolic mental disorders is discussed. Experimental clinical effects modification ECS results exogenous manipulation consequent modulation are also outlined....
Trypanosoma cruzi, the etiologic Chagas' disease agent, induces changes in protein pattern of human placenta syncytiotrophoblast. The glucose transporter protein-1 (GLUT1) is primary isoform involved transplacental transport. We carried out vitro assays to determine if T. cruzi infection would induce placental GLUT1 expression under normal and high concentration glucose. Using Western blot immunohistological techniques, was determined villi cultured or concentrations glucose, with without...
Introducción: la diabetes mellitus es una patología metabólica crónica con alta frecuencia en los adultos mayores estimada el 30% de esta etapa vida. Al ser enfermedad sistémica afecta a todos órganos y sistemas, especialmente aparato cardiovascular, visión, riñón sistema nervio tanto periférico como central. Su manejo depende participación activa persona afectada su entorno para lo cual fundamental educación diabetológica actividades que ayuden mantener estado físico al autocuidado. Desde...
Salt sensitivity (SS) is associated with increased cardiovascular risk in diabetic patients. This abnormal mechanism results an renal oxydation and decreased urinary sodium excretion if it maintained over time can develop hypertension its complications. Currently the Western diet has limited content of polyunsaturated fatty acids, antioxidant capacity such as ecoisapentaneoico acid (EPA). Therefore we hypothesized that nutritional supplementation EPA, prevents SS DM rats by decreasing...