A5061928528- Phytochemicals and Antioxidant Activities
- Bee Products Chemical Analysis
- Advancements in Transdermal Drug Delivery
- Essential Oils and Antimicrobial Activity
- Nanocomposite Films for Food Packaging
- Microencapsulation and Drying Processes
- Dermatology and Skin Diseases
- Fermentation and Sensory Analysis
- Proteins in Food Systems
- Plant Growth Enhancement Techniques
- Lignin and Wood Chemistry
- Ginkgo biloba and Cashew Applications
- Cynara cardunculus studies
- Salivary Gland Disorders and Functions
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Curcumin's Biomedical Applications
- HER2/EGFR in Cancer Research
- Photodynamic Therapy Research Studies
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Horticultural and Viticultural Research
- Ocular Surface and Contact Lens
- Antioxidants, Aging, Portulaca oleracea
- Probiotics and Fermented Foods
University of Cagliari
2021-2025
Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2024-2025
Fundación General
2023
Grape pomace is the main solid residue of wine industry, mainly composed seeds, skins and stalks, all containing high amounts valuable phytochemicals. Considering its potential, in this review, an outlook on different resources products, which can be obtained by recovery grape provided. Special attention has been devoted to analysis chemical, physical biotechnological processes applied also value compounds such as supplements, nutraceuticals cosmeceuticals, that manufactured. In particular,...
The present study is aimed at valorizing grape pomace, one of the most abundant winery-making by-products Mediterranean area, through extraction main bioactive compounds from skin pomace and using them to manufacture innovative nanoformulations capable both avoiding damages promoting skincare. phytochemicals were recovered maceration in hydroethanolic solution. Catechin, quercetin, fisetin gallic acid, which are known for their antioxidant power, detected as extract. Liposomes phospholipid...
Grape seeds are agro-industrial by-products, which if improperly managed, may be responsible for socioeconomic and environmental problems. Nevertheless, it is possible to effectively valorize them by means of extraction the bioactive compounds, especially antioxidant phenolic molecules, using a safe, green, environmentally-friendly extractive medium (i.e., hydro-glyceric solution). In present study, was performed from two Lebanese varieties, Obeidi Asswad Karech, three international...
Grape pomaces have recently received great attention for their richness in polyphenols, compounds known to exert anti-inflammatory and antioxidant effects. These pomaces, however, low brain bioavailability when administered orally due extensive degradation the gastrointestinal tract. To overcome this problem, Nasco pomace extract was incorporated into a novel nanovesicle system called nutriosomes, composed of phospholipids (S75) water-soluble maltodextrin (Nutriose ® FM06). Nutriosomes were...
Grape pomace represents 60%, by weight, of the solid side-streams wine-making process. The quantities produced, seasonality, and presence polyphenols pose economic environmental issues that require proper management approaches based on principles sustainability circular economy. present work focuses combined application solid–liquid extraction from ground grape using a hydroethanolic mixture composting exhausted pomace. obtained results support possibility recovering approximately 76.5 g...
The aim of this work was the simultaneous loading quercetin and mint essential oil (mint oil) in phospholipid vesicles specifically tailored to obtain an antibacterial antioxidant mouthwash. were prepared using soy lecithin Tween 80 as bilayer components, a mixture phosphate buffer solution (33%), propylene glycol (33%) ethanol dispersing phase. formation regularly shaped, spherical unilamellar confirmed by cryogenic transmission electron microscopy analyses. Similarly, light scattering...
A total green nanotechnological nasal spray has been manufactured and proposed as an alternative treatment of rhinitis rhinosinusitis. It was obtained by combining the strengthening effect liposomes on barrier function, hydrating lubricating properties sodium hyaluronan anti-inflammatory antioxidant activities extract
The aim of the present study was to evaluate effectiveness a Cannonau pomace extract loaded in nutriosomes intestinal oxidative stress and subacute model Parkinson disease compare results with those previously obtained Nasco same nutriosomes. In this study, extracted using ultrasound-assisted maceration obtain polyphenol-rich extract. at two different concentrations (5 10 mg/mL) used deliver were main physico-chemical technological characteristics vesicles, along their stability over time...
Culture of plant cells or tissues is a scalable, sustainable, and environmentally friendly approach to obtain extracts secondary metabolites uniform quality that can be continuously supplied in controlled conditions, independent geographical seasonal variations, environmental factors, negative biological influences. In addition, extracted/obtained from the by-products other industrial cultivations such as Lavandula angustifolia Miller (L. angustifolia), which largely cultivated for...
In this work oleuropein and lentisk oil have been co-loaded in different phospholipid vesicles (i.e., liposomes, transfersomes, hyalurosomes hyalutransfersomes), to obtain a formulation capable of both inhibiting the production markers connected with inflammation oxidative stress promoting skin repair. Liposomes were prepared using mixture phospholipids, oil. Tween 80, sodium hyaluronate or their combination added hyalutransfersomes. Size, polydispersity index, surface charge stability on...
Grape pomace is the main by-product generated during winemaking process; since it still rich in bioactive molecules, especially phenolic compounds with high antioxidant power, its transformation beneficial and health-promoting foods an innovative challenge to extend grape life cycle. Hence, this work, phytochemicals contained were recovered by enhanced ultrasound assisted extraction. The extract was incorporated liposomes prepared soy lecithin nutriosomes obtained combining Nutriose FM06®,...
Nasco and Bovale grape pomace extracts, alone or in association, were loaded nanoemulsions tailored for cosmetic application, using Kolliphor®RH40 (kolliphor) as the synthetic surfactant, Olivem®1000 (olivem) natural one, lecithin cosurfactant. Pink transparent milky dispersions, a function of used extract obtained to be cosmeceutical serum milk. The sizes nanoemulsion droplets small (≈77 nm with kolliphor ≈141 olivem), homogenously dispersed (~0.24 ~0.16 highly negatively charged (≈-43 mV...
Inflammatory skin disorders are the fourth leading cause of chronic non-fatal conditions, which have a serious impact on patient quality life. Due to their treatment with conventional corticosteroids, often result in poor therapeutic efficacy, relapses and systemic side effects from prolonged therapy, these diseases represent global burden that negatively impacts economy. To avoid problems optimize corticosteroid benefits, beclomethasone was loaded into liposome formulations specifically...
A pre-formulation study was carried out to obtain liposomal formulations of mometasone furoate as an alternative system marketed forms corticosteroid for the treatment inflammatory skin lesions. Mometasone loaded in glycerosomes and glyceroethosomes, which were also modified with hyaluronic acid (glyceroethohyalurosomes). Vesicles designed, elaborated, characterized, their biocompatibility, efficacy against oxidative stress lesions assessed vitro, human epidermal cells, vivo, a mouse...