A5005427159- Glioma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Family and Patient Care in Intensive Care Units
- Pleural and Pulmonary Diseases
- Neurofibromatosis and Schwannoma Cases
- Respiratory Support and Mechanisms
- Medical Imaging and Pathology Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Microtubule and mitosis dynamics
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Advanced Radiotherapy Techniques
- Neonatal Health and Biochemistry
- Ocular Oncology and Treatments
- Dental Research and COVID-19
- Infection Control in Healthcare
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ovarian cancer diagnosis and treatment
- Radiation Therapy and Dosimetry
- Immunotherapy and Immune Responses
- Tuberous Sclerosis Complex Research
- Hedgehog Signaling Pathway Studies
- Medical Device Sterilization and Disinfection
Yale New Haven Hospital
2020-2024
Yale University
2015-2024
Palmetto Hematology Oncology
2020
Children's National
2008-2013
University of Miami
1963-1973
Jackson Memorial Hospital
1967
Boston University
1957-1961
Harvard University
1961
University of Massachusetts Boston
1957
Abstract Nine women presented an unusual and distinctive syndrome consisting of a chronic ultimately life-threatening illness with high fever, night sweats, weight loss severe dyspnea. Tuberculosis was the initial diagnosis in most cases, but patients' condition deteriorated on chemotherapy. Asthma occurred for first time onset six patients, whereas three had neither asthma nor blood eosinophilia. The roentgenograms showed characteristic, rapidly progressive, dense pneumonic infiltrates...
Postoperative radiotherapy to the craniospinal axis is standard-of-care for pediatric medulloblastoma but associated with long-term morbidity, particularly in young children. With advent of modern adjuvant chemotherapy strategies, postoperative deferral has gained acceptance children younger than 3 years, although it remains controversial older children.To analyze recent national treatment patterns and implications overall survival patients ages 8 years.Using National Cancer Data Base, years...
Abstract Background The increasing number of childhood cancer survivors necessitates continued follow‐up to monitor for long‐term complications. Inequities in loss patients enrolled on pediatric clinical trials have not been well studied. Methods This was a retrospective study 21,084 residing the United States phase 2/3 and 3 Children's Oncology Group (COG) between January 1, 2000 March 31, 2021. Rates COG were evaluated using log‐rank tests multivariable Cox proportional hazards regression...
Low grade gliomas (LGGs) are the most common type of brain tumors diagnosed in children. The presentation intracranial pediatric patients is varied and diverse. early identification treatment LGGs important to achieve favorable outcomes. Although personality changes can be a symptom tumors, they rarely only main presenting feature. In addition central nervous system (CNS) associated with psychological endocrine conditions, contributing broad differential diagnosis. Because symptoms such as...
Abstract Efficacy of BRAF V600E targeted therapies in brain tumors harboring the mutation has been shown several case reports and is currently being studied larger clinical trials. Monotherapy with vemurafenib associated significant side effects, including rashes, papillomas, squamous cell carcinomas. Here we describe an adolescent female anaplastic ganglioglioma skin reaction to subsequent tumor response tolerance BRAF/MEK inhibitor combination dabrafenib trametinib without recurrence...
Pilocytic astrocytomas are the most common pediatric brain tumors, typically presenting as low-grade neoplasms. We report two cases of pilocytic astrocytoma with atypical tumor progression. Case 1 involves a 12-yr-old boy an unresectable suprasellar tumor, negative for
<sec> <title>BACKGROUND</title> Type 1 Diabetes (T1D) is one of the most common chronic conditions diagnosed during childhood. When a child first with T1D parent primary manager condition, responsibility begins to switch over adolescence. Resources help children begin learn about managing pre-adolescence (8-12 years) will allow them practice diabetes management skills. By applying serious game mechanisms virtual reality (VR), it creates an opportunity for pre-adolescents in safe and...
Craniopharyngioma is one of the most common non-glial intracranial tumors childhood. Its relation to Rathke's cleft cyst (RCC) controversial, and both lesions have been hypothesized lie on a continuum cystic ectodermal sellar region. The authors report 7-year-old boy who presented with decreased visual acuity, presumably at least 2 years' duration, was found 5.2-cm lesion rim enhancement. Histological examination resected showed mixture areas simple RCC morphology focal squamous metaplasia...
INADEQUATE alveolar ventilation leads to retention of carbon dioxide, with accompanying respiratory acidosis. Most patients chronic obstructive emphysema die this complication. The importance infection, sedation and the incautious use oxygen in pathogenesis ventilatory failure has been well described,1 2 3 4 5 6 7 8 9 10 11 necessity increasing is stressed.5 , 12 13 14 A variety mechanical aids chemical stimuli are recommended.10 15 16 17 18 19 20 21 22 23 24 assisters current favor country...
Lupus erythematosus panniculitis (LEP) most commonly presents as multiple deep subcutaneous indurated nodules or erythematous plaques involving the face and proximal extremities.1 Lipoatrophy is another characteristic feature on resolution.2,3 Histopathologically, LEP shows lymphoplasmacytic lobular panniculitis, often with dermal mucin deposition, hyaline fat necrosis, lymphoid follicles. There may be epidermal vacuolar change a perivascular periadnexal lymphocytic infiltrate prominent plasma cells.
Pediatric midline tumors are devastating high-grade lesions with a dismal prognosis and no curative surgical options. Here, the authors report clinical presentation, management, whole-exome sequencing (WES), clonality analysis of patient radically resected H3K27M -mutant pineal parenchymal tumor (PPT) spine metastases consistent PPT intermediate differentiation (PPTID). They identified somatic mutations in H3F3A (H3K27M), FGFR1 , NF1 both original PPTID metastases. also found 12q...
Disparities in survival by race/ethnicity, socioeconomic status (SES), and geography adolescent young adult (AYA) patients with central nervous system (CNS) tumors have not been well studied.A retrospective cohort study utilizing the Surveillance, Epidemiology, End Results (SEER) database was conducted for AYA diagnosed primary CNS tumors. Adjusted hazard ratios (aHR) were calculated using a multivariate Cox proportional model to evaluate association between SES, rurality, of death.All...