A5083498619- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Chronic Kidney Disease and Diabetes
- Systemic Lupus Erythematosus Research
- Genetic and Kidney Cyst Diseases
- COVID-19 Clinical Research Studies
- Maternal and fetal healthcare
- Gender Politics and Representation
- Reproductive tract infections research
- COVID-19 and healthcare impacts
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Gender, Feminism, and Media
- COVID-19 Impact on Reproduction
- Pregnancy and preeclampsia studies
- Housing, Finance, and Neoliberalism
- Chemokine receptors and signaling
- Muscle and Compartmental Disorders
- Autoimmune Bullous Skin Diseases
- Homelessness and Social Issues
- Intimate Partner and Family Violence
- SARS-CoV-2 and COVID-19 Research
- Vasculitis and related conditions
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Gestational Trophoblastic Disease Studies
Center for Discovery
2025
Icahn School of Medicine at Mount Sinai
2020-2024
Hackensack Meridian Health
2023
Health Net
2023
Mount Sinai Hospital
2021
University of Liverpool
2019-2020
Kidney glomerulosclerosis commonly progresses to end-stage kidney failure, but pathogenic mechanisms are still poorly understood. Here, we show that podocyte expression of decay-accelerating factor (DAF/CD55), a complement C3 convertase regulator, crucially controls disease in murine models adriamycin (ADR)-induced focal and segmental (FSGS) streptozotocin (STZ)-induced diabetic glomerulosclerosis. ADR induces enzymatic cleavage DAF from surfaces, leading activation. deficiency or prevention...
The deposition of antipodocyte autoantibodies in the glomerular subepithelial space induces primary membranous nephropathy (MN), leading cause nephrotic syndrome worldwide. Taking advantage glomerulus-on-a-chip system, we modeled human MN induced by anti-PLA2R antibodies. Here show that exposure podocytes expressing PLA2R to serum results IgG and complement activation on their surface, loss chip permselectivity albumin. C3a receptor (C3aR) antagonists as well C3AR gene silencing reduced...
The effects of SARS-CoV-2 infection on individuals with immune-mediated glomerulonephritis, who are often undergoing immunosuppressive treatments, unknown. Therefore, we created the International Registry COVID in glomerulonephritis (IRoc-GN) and identified 40 patients COVID-19 followed centers North America Europe. Detailed information diagnosis, kidney parameters, baseline immunosuppression prior to were recorded, as well clinical presentation, laboratory values, treatment, complications,...
B cell depleting therapies permit immunosuppressive drug withdrawal and maintain remission in patients with frequently relapsing nephrotic syndrome (FRNS) or steroid–dependent (SDNS), but lack of biomarkers for treatment failure. Post-depletion immune reconstitution may identify patients, previous characterizations suffered from methodological limitations flow cytometry. Time-of-flight mass cytometry (CyTOF) is a comprehensive analytic modality that simultaneously quantifies over 40 cellular...
It is recognized that stressors encountered during the COVID-19 pandemic created an environment exacerbated DV. COVID disproportionately impacted at-risk populations, but it unclear if these social determinants of health disparities similarly impact incidence This study aimed to identify and highlight affected communities within state New Jersey (NJ) were by domestic violence (DV) pandemic. The design was retrospective cross-sectional. Public data from NJ Department Health, Law Safety, US...
Abstract Juvenile-onset lupus nephritis (LN) affects up to 80% of juvenile-onset systemic erythematosus patients (JSLE). As the exact role human renal glomerular endothelial cells (GEnCs) in LN has not been fully elucidated, aim this study was investigate their involvement LN. Conditionally immortalised GEnCs (ciGEnCs) were treated with pro-inflammatory cytokines known be involved pathogenesis and also LPS. Secretion surface expression proteins quantified via ELISA flow cytometry. NF-κΒ...
Key Points Mortality and incidence of AKI do not differ between coronavirus disease 2019 (COVID-19) patients with or without glomerular diseases. The main predictor is pre-COVID-19 eGFR, independent the presence GN. Incomplete kidney function recovery after COVID-19-associated more common in GN than controls. Background acute long-term effects severe respiratory syndrome 2 infection individuals are still unclear. To address this relevant issue, we created International Registry COVID-19...
The vaginal microbiome exists in a dynamic state and its disruption, by diminution of Lactobacillus concentrations, can induce microbial imbalance with significant health consequences, such as increased risk sexually transmitted infection (STI) acquisition, preterm labor, low birth weight babies. This delicate balance microbes be affected many processes mechanical practices (i.e. douching) hormonal changes: physiologic menstrual cycle, menopause, puberty), pathologic PCOS), exogenous...
Background: Complement activation is thought to play a major pathogenic role in membranous nephropathy (MN), but its effector mechanisms are still unclear. Even less investigated the of podocyte-expressed complement regulators, including decay accelerating factor (DAF) disease pathophysiology. Methods: We induced MN by serial injections cationic bovine serum albumin (cBSA) WT, DAF -/- , and C3aR BALB/c mice measured severity (by albuminuria, BUN, albumin, glomerular histological changes)...
Patients with autosomal dominant polycystic kidney disease (ADPKD), a genetic due to mutations of the PKD1 or PKD2 gene, show signs complement activation in urine and cystic fluid, but their pathogenic role cystogenesis is unclear. We tested causal relationship between cyst growth using Pkd1KO renal tubular cell line newly generated conditional Pkd1–/– C3–/– mice. Pkd1-deficient cells have increased expression complement-related genes (C3, C5, CfB, C3ar, C5ar1), while gene protein regulators...
Key Points Genetically induced decay-accelerating factor (DAF) overexpression prevents adriamycin (ADR)-induced focal segmental glomerulosclerosis (FSGS) in mice. Pharmacologic inhibition of DAF cleavage reduces complement activation the glomeruli and albuminuria murine ADR-induced FSGS. Inhibition represents a valuable therapeutic strategy for FSGS and, potentially, other glomerular diseases.
Introduction: Pregnant leukemia patients should be offered continuation or termination of pregnancy. Treatment in reproductive-age includes consideration contraception. Hormonal intrauterine devices (IUDs) prevent pregnancy and decrease menstrual bleeding. Despite safety data for IUDs immunocompromised patients, infection vaginal bleeding concerns may inhibit their placement. Case Report: We report a case 28-year-old female at 13 weeks 4 days gestation with acute promyelocytic (APL) who...