A5011827150- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Donation and Transplantation
- Congenital Anomalies and Fetal Surgery
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Liver physiology and pathology
- Gallbladder and Bile Duct Disorders
- Metabolism and Genetic Disorders
- Renal Transplantation Outcomes and Treatments
- Neuroblastoma Research and Treatments
- Congenital Heart Disease Studies
- Childhood Cancer Survivors' Quality of Life
- Muscle metabolism and nutrition
- Parasites and Host Interactions
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic function and diabetes
- Xenotransplantation and immune response
- Clinical Nutrition and Gastroenterology
- Amino Acid Enzymes and Metabolism
- Sarcoma Diagnosis and Treatment
- Genetic and Kidney Cyst Diseases
- Kidney Stones and Urolithiasis Treatments
- Amoebic Infections and Treatments
Hospital Sírio-Libanês
2014-2023
AC Camargo Hospital
2003-2021
Development Fund
2016
Universidade de São Paulo
2016
Hospital São Paulo
1999-2014
Gdańsk Medical University
2002
University of Pittsburgh
1987-1989
PURPOSE: To improve survival and reduce operative morbidity mortality in children with primary epithelial liver tumors by using preoperative chemotherapy, as well to collect information on the epidemiology, natural history, prognostic factors. PATIENTS AND METHODS: Forty hepatocellular carcinoma (HCC) were registered onto Group for Epithelial Liver Tumors International Society of Pediatric Oncology’s first study from January 1990 February 1994. The outcome could be analyzed 39 those...
In Brief Background Hepatic artery thrombosis (HAT) increases morbidity and mortality after liver transplantation (LT). The identification of risk factors for HAT may aid transplant teams in the development strategies aimed at reducing HAT. This article describes outcomes LT. Methods report a retrospective study (1995 to 2015) primary pediatric living donor LT (LDLT). Pretransplant technical variables were included study. Binary logistic regression was used data analysis. Results 656 LDLT....
The availability of living donors allows transplant teams to indicate donor liver transplantation (LDLT) early in the course disease before occurrence life-threatening complications. Late referral centers is still a problem and can compromise success procedure. aim this study was examine perioperative factors associated with patient graft survival for 430 consecutive pediatric LDLT procedures at Sirio-Libanes Hospital/A. C. Camargo Hospital (São Paulo, Brazil) between October 1995 April...
Ascites is the most common complication of cirrhosis and in adults it associated with 50% mortality at 5 years if patients do not receive a liver transplant. The occurrence hyponatremia these has been increased on waiting list. importance serum sodium levels presence ascites pediatric setting remain to be clarified. A retrospective analysis transplant list was carried out between October 2000 February 2012. primary objective this study evaluate association pretransplant variables within 90...
Biliary atresia (BA) is the main diagnosis leading to liver transplantation (LT) in children. When diagnosed early life, a Kasai portoenterostomy (Kasai-PE) can prevent or postpone LT. Instances of previous operations result difficulties during We hypothesized that Kasai-PE could affect LT outcomes. A retrospective cohort study 347 BA patients submitted between 1995 and 2013 at Hospital Sírio-Libanês A. C. Camargo Cancer Center was conducted. Patients were divided into those with failure...
Maple syrup urine disease (MSUD) is an autosomal recessive associated with high levels of branched-chain amino acids. Children MSUD can present severe neurological damage, but liver transplantation (LT) allows the patient to resume a normal diet and avoid further damage. The use living related donors has been controversial because parents are obligatory heterozygotes. We report case 2-year-old child who underwent donor LT. was patient's mother, his then used as domino graft. postoperative...
The technique of vascular reconstruction plays a major role in the outcome living donor liver transplantation (LDLT). An increased use grafts (VGs) as replacements for sclerotic portal veins has become standard our group. aim this study was to analyze factors associated with vein thrombosis (PVT) pediatric LDLT. We performed retrospective analysis 486 primary LDLT procedures between October 1995 and May 2013. VGs used included inferior mesenteric veins, ovarian recipient internal jugular...
Untreated tyrosinemia type 1 (HT1) is manifested by liver failure associated with renal tubular dysfunction, growth failure, and rickets. The indication for transplantation (LT) restricted to non-responders 2-(2-nitro-4-trifluoromethylbenzoyl)-1, 3-cyclohexanedione (NTBC) treatment, patients not treated NTBC or HCC. aim of this study report on a series naive HT1 submitted LT along the prevalence HCC in their explants.This retrospective 16 children who underwent between January 1993 December...
In Brief Background Biliary complications (BCs) remain an important cause of morbidity after pediatric liver transplantation. Technical factors have already been implicated in the development BCs. Previous reports associated use partial grafts, particularly living donor with a higher incidence Our aim is to study BCs large cohort transplant recipients. Methods Retrospective 670 children (<18 years age) who underwent primary between March 2000 and January 2015. Patients did not develop were...
Infants with end-stage liver disease represent a treatment challenge. Living donor transplantation (LDLT) is the only option for timely in many areas of world, adding to technical difficulties procedure. Factors that affect morbidity and mortality can now be determined, which opens new era improvement. We have accumulated an 11-year experience LDLT children weighing<10 kg. From October 1995 2006, total 222 patients<18 years age were performed; 129 primary 7 retransplants (4 3 deceased...
The Pediatric End-Stage Liver Disease (PELD) scoring system is a formula developed to provide continuous numerical assessment of the risk death in order allocate livers children need transplantation. PELD was introduced Brazil July 2006. An important change made system: final number for listing patients less than 12 years old transplantation calculated score multiplied by 3. consequences this allocation policy were analyzed 2 ways research: nationally and state São Paulo (SP State). In...
The pathogenesis of hyperacute renal rejection consists a nonspecific effector cascade that invokes most the components typical acute inflammatory response. Platelet-activating factor (PAF) represents recent and perhaps significant mediator promoting agent this phenomenon. These studies evaluated SRI 63–441, novel, synthetic, potent PAF receptor antagonist available, alone in combination with other prostanoids, for their ability to influence response prolong xenograft survival function model...
The increasing number of transplants performed each year has led to the identification unusual diseases in liver grafts from asymptomatic donors that were unrecognized before transplantation. Here we report our experience with patients who received infected schistosomiasis. From September 1991 August 2010, 482 pediatric at A. C. Camargo Hospital/Sírio-Libanês Hospital (São Paulo, Brazil). For Schistosoma mansoni infections, pathology slides for recipients reviewed; these included...
Living donor liver donation (LDLD) is an alternative to cadaveric donation. We aimed at identifying risk factors and developing a score for prediction of postoperative complications (POCs) after LDLD in donors. This retrospective cohort study 688 donors between June 1995 February 2014 Hospital Sírio-Libanês A.C. Camargo Cancer Center, São Paulo, Brazil. Primary outcome was POC graded ≥III according the Clavien-Dindo classification. Left lateral segment (LLS), left lobe (LL), right resections...
Portal vein thrombosis (PVT) may occur at any time following liver transplantation. We describe our experience with portal recanalization in cases of after Twenty-eight children (5%) out 566 transplant recipients underwent using a transmesenteric approach. All received left hepatic segments, developed PVT, and had symptoms or signs hypertension. was performed via the route all cases. Twenty-two (78.6%) patients successful stent placement. They oral anticoagulants procedure, clinical...
In the setting of metastatic or locally advanced adrenocortical carcinoma, a limited number therapies are available and their efficacy is generally below modest. The backbone treatment remains surgery, even for disease, whenever it possible, mitotane. Chemotherapy can be used with results. A small subset patients carcinoma may have high mutational burden harbor mutations in mismatch-repair genes.We report 40-year old 28-year-old female refractory to multiple treatments.Next-generation...
Carcinoid tumors are very rare both in children and adults. About 85% of these develop the gastrointestinal tract. The objective present study was to describe our experience with treated carcinoid tumors, investigate frequency morphological findings results.
During left lateral segmentectomy for live-donor liver transplant, the vascular inflow to segment IV can be compromised. An area of ischemia seen intraoperatively and further resection may needed prevent necrosis abscess formation.From July 1995 February 2007, 324 consecutive living donor transplantations were performed at Hospital A. C. Camargo Sirio-Libanes, Sao Paulo, Brazil. Two hundred eleven segments transplanted in this period. Data on 204 donors available analysis.There 108 female 96...
Pediatric living donor liver transplantation (PLDLT) is a successful therapeutic option for children with chronic and acute disease. After early transplant results, many technical advancements were introduced in the field to reduce rate of complications improve survival. The aim this study present outcomes 975 primary PLDLTs 3 periods: initial practice (period 1, 29 patients, January 1995 December 1999), second period 2, 331 2000 2009), third [P3], 615 2010 September 2019). Among refinements...
Background. Data describing the technical aspects of living donor (LD) domino liver transplantation (DLT) in maple syrup urine disease (MSUD) are limited. The largest published series includes only 3 cases. One great challenge this procedure is to ensure adequate vascular stumps for LD, MSUD patient, and recipient graft. Here, we describe our experience 11 cases LD-DLT MSUD, highlighting LD-DLT. Methods. From September 2012 2017, patients with underwent LD at institution, livers were used as...
Abstract LT started in LA 1968, and pediatric records are available starting the 1990s. Currently, eight countries perform . Registries by national organizations fail to report robust data on The aim of this paper was activity Data were gathered retrospectively through information registries websites from local centers. Of that activity, Brazil, Argentina, Mexico, Colombia have adequate numbers performed. These concentrate most for A total 4593 reported Websites do not provide open...
Hepatoblastomas (HBs) recapitulate liver development. It is possible that HBs result from malignant transformation of hepatic precursor cells, and they may reflect a blockage in normal Here we study the expression cytokeratins (CKs) order to delineate immunoprofile relationship with development, as well vimentin alphafetoprotein (AFP), HBs. Immunohistochemistry was performed tissue microarray (TMA) containing representative areas 18 (fetal and/or embryonal mesenchymal); also reviewed 11...