A5020009191- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Trace Elements in Health
- Forensic Anthropology and Bioarchaeology Studies
- Heavy metals in environment
- Child Nutrition and Water Access
- Autism Spectrum Disorder Research
- Health, Environment, Cognitive Aging
- Pleistocene-Era Hominins and Archaeology
- Radioactivity and Radon Measurements
- Environmental Justice and Health Disparities
- Effects and risks of endocrine disrupting chemicals
- Marine animal studies overview
- Nutritional Studies and Diet
- Mass Spectrometry Techniques and Applications
- Pacific and Southeast Asian Studies
- Metabolomics and Mass Spectrometry Studies
- Air Quality and Health Impacts
- Electrochemical Analysis and Applications
- Bone and Dental Protein Studies
- Indigenous Studies and Ecology
- Isotope Analysis in Ecology
- Analytical chemistry methods development
- Archaeology and ancient environmental studies
- Toxic Organic Pollutants Impact
Icahn School of Medicine at Mount Sinai
2016-2025
Mount Sinai Health System
2021-2023
National Confidential Enquiry into Patient Outcome and Death
2023
National Institute for Environmental Studies
2022
Karolinska Institutet
2022
Mount Sinai Medical Center
2019
Mount Sinai Hospital
2019
The University of Sydney
2011-2017
Westmead Institute
2012-2017
Westmead Hospital
2011-2017
Genetic and environmental factors contribute to the etiologies of autism spectrum disorder (ASD), but evidence specific exposures susceptibility windows is limited. Here we study monozygotic dizygotic twins discordant for ASD test whether fetal postnatal metal dysregulation increases risk. Using validated tooth-matrix biomarkers, estimate pre- post-natal exposure profiles essential toxic elements. Significant divergences are apparent in uptake between cases their control siblings, only...
Ironing out the details of mucosal healing Anemia is a frequent complication disorders such as inflammatory bowel disease, occurring in part result increased bleeding into intestine. Bessman et al. show that peptide hormone hepcidin, which regulates systemic iron homeostasis, required for intestinal repair mouse model disease (see Perspective by Rescigno). This effect was independent hepatocyte-produced hepcidin and levels. Instead, production conventional dendritic cells necessary...
Elemental records in teeth reveal prehistoric seasons of Neanderthal birth, weaning, childhood illness, and neurotoxic exposures.
Element response variations under different laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) operating conditions were investigated to identify important factors for selecting an internal standard (IS) quantitative elemental bio-imaging. Analytes covering a range of atomic masses and first ionisation potentials (FIP) selected investigate the signal variation with changes in spot diameter, mass bias cell sampling position. In all cases, IS improved experimental...
Metal exposure alters neurodevelopmental outcomes; little is known about critical windows of susceptibility when exerts the strongest effect. To examine associations between dentine biomarkers manganese (Mn), zinc (Zn) and lead (Pb) later childhood behaviors. Subjects enrolled in a longitudinal birth cohort study Mexico City provided naturally shed deciduous teeth. We estimated weekly prenatal postnatal Mn, Zn Pb concentrations teeth using laser ablation-inductively coupled plasma-mass...
Studies addressing health effects of manganese (Mn) excess or deficiency during prenatal development are hampered by a lack biomarkers that can reconstruct fetal exposure. We propose method using the neonatal line, histological feature in deciduous teeth, to identify regions mantle dentine formed at different periods. Micromeasurements Mn these may be used exposure specific times development. To test our hypothesis, we recruited pregnant women before 20 weeks gestation from cohort...
The aim of this study was to assess the validity micro-spatial dentine lead (Pb) levels as a biomarker for accurately estimating exposure timing over prenatal and early childhood periods long-term cumulative Pb. In prospective pregnancy cohort sub-sample 85 subjects, we compared Pb measured using laser ablation-inductively coupled plasma mass spectrometry with concentrations in maternal blood collected second third trimesters, bone, umbilical cord blood, serial samples from ages 3 months ≥6...
Baby tooth analysis shows that fetal and early postnatal zinc-copper metabolic rhythms predict autism risk.
Abstract Early life stress can disrupt development and negatively impact long-term health trajectories. Reconstructing histories of early exposure to external stressors is hampered by the absence retrospective time-specific biomarkers. Defects in tooth enamel have been used reconstruct but methods are subjective do not identify specific biological systems impacted stressors. Here we show that physical social impart biochemical signatures primate teeth be retrieved objectively timing...
Abstract We investigate the role of mitochondrion, an organelle highly sensitive to environmental agents, in influence prenatal air pollution exposure on neurodevelopment and behavior 96 children with autism spectrum disorder (ASD) [45 neurodevelopmental regression (NDR); 76% Male; mean (SD) age 10 y 9 m (3 m)]. Mitochondrial function was assessed using Seahorse XFe96 fresh peripheral blood mononuclear cells. Second third trimester average maximal daily fine particulate matter diameter ≤2.5...
The developmental timing of exposures to toxic chemicals or combinations may be as important the dosage itself. This concept is called “critical windows exposure.” time boundaries such can detected if exposure data are collected repeatedly in short intervals. development tooth-matrix biomarkers which provide prenatal and postnatal measures repeated intervals data. Using teeth, we use reverse distributed lagged models (DLMs) incorporate weekly estimate time-varying associations with effects....
A method for quantitative analysis of biological soft tissues by laser ablation-inductively coupled plasma-mass spectrometry has been developed. Polymer film standards were produced spin coating spiked solutions polymethylmethacrylate onto quartz substrates. Calibration curves throughout the range 0–400 μg g−1 yielded correlation coefficients better than 0.999 66Zn and 63Cu. Spiked, homogenised tissue quantified LA-ICP-MS against thin standards. The results agreed with values calculated from...
ABSTRACT The rapid increase in fatty liver disease (FLD) incidence is attributed largely to genetic and lifestyle factors; however, environmental toxicants are a frequently overlooked factor that can modify the effects of more common causes FLD. Chronic exposure inorganic arsenic (iAs) associated with humans animal models, but neither mechanism action nor combinatorial interaction other disease-causing factors has been fully investigated. Here, we examined contribution iAs FLD using...
Immature wild orangutans cyclically vary mothers’ milk consumption over 8 or more years, weaning later than other mammals.