A5059188722- Soybean genetics and cultivation
- Human-Animal Interaction Studies
- Nicotinic Acetylcholine Receptors Study
- Legume Nitrogen Fixing Symbiosis
- Genetic and phenotypic traits in livestock
- Neuroendocrine regulation and behavior
- Genetic Mapping and Diversity in Plants and Animals
- Neurobiology and Insect Physiology Research
- Ion channel regulation and function
- Plant pathogens and resistance mechanisms
- Agronomic Practices and Intercropping Systems
- Animal Genetics and Reproduction
- Morphological variations and asymmetry
- dental development and anomalies
- Veterinary Medicine and Surgery
- Receptor Mechanisms and Signaling
- Veterinary Orthopedics and Neurology
- Cholinesterase and Neurodegenerative Diseases
- Genetics and Plant Breeding
- Venomous Animal Envenomation and Studies
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Nematode management and characterization studies
- Ion Channels and Receptors
- Marine animal studies overview
University of Utah
2014-2025
National Human Genome Research Institute
2007-2010
Cancer Genetics (United States)
2009-2010
National Institutes of Health
2009-2010
Waltham Centre for Pet Nutrition
2009
Cornell University
2007
University of California, Los Angeles
2007
University of Southern California
2007
Fred Hutch Cancer Center
2002
Pontificia Universidad Católica de Valparaíso
1996
The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate genetic basis size. First, through genome-wide scan, we identified major quantitative trait locus (QTL) on chromosome 15 influencing variation within single breed. Second, examined 15-megabase interval surrounding QTL small and giant breeds found marked evidence for selective sweep spanning gene (IGF1), encoding...
Soybean [ Glycine max (L.) Merr.] yield, when regressed on water needed to replenish 0 100% seasonal evapotranspiration (ET), generates an estimate of season‐specific water‐use efficiency (WUE). The impact unpredictable deficits might be lessened if high‐yielding genotypes had a smaller beta. Our objective was determine the genetic basis beta and carbon isotope discrimination (CID), theorized indicator transpiration (TE). A ‘Minsoy’ × ‘Noir 1’ population 236 recombinant inbred lines (RILs),...
Abstract The first genetic transcript map of the soybean genome was created by mapping one SNP in each 1141 genes or more three recombinant inbred line populations, thus providing a picture distribution genic sequences across mapped portion genome. Single-nucleotide polymorphisms (SNPs) were discovered via resequencing sequence-tagged sites (STSs) developed from expressed sequence tag (EST) sequence. From an initial set 9459 polymerase chain reaction primer sets designed to diverse genes,...
Dog Coats Shed Genetic Secrets The coats of domestic dogs show great variation—long, short, straight, wavy, curly, wiry, or smooth. To investigate how this variation arises, Cadieu et al. (p. 150 , published online 27 August) performed genome-wide association studies on 80 different dog breeds. coat phenotype could be dissected into three simple traits length, curl, and growth pattern texture with each trait controlled by one major gene, FGF5 (fibroblast factor-5), KRT71 (keratin-71), RSPO2...
ABSTRACT Molecular markers provide a rapid approach to breeding for desired agronomic traits. To use them, it is necessary determine the linkage between quantitative trait loci (QTLs) and such markers. The objective of this research was in recombinant inbred (RI) soybean [ Glycine max (L.) Merrill] populations. do this, RI segregants were characterized molecular genetic traits measured several different environments. QTLs then identified by interval mapping. Agronomic compared large (about...
Many agronomic traits of interest to plant breeders are quantitative. Recombinant inbred (RI) lines particularly useful in genetic mapping studies quantitative traits. A recombinant population was derived from the Glycine max (L.) Merr. parents ‘Minsoy’ and ‘Noir 1’. This soybean used investigate basis several traits: days flower (Rl), maturity (R8), reproductive period (RS‐R1), height, lodging score, height divided by (the ability tall plants stand upright), seed protein content, oil size,...
A large recombinant inbred population of soybean has been characterized for 220 restriction fragment-length polymorphism (RFLP) markers. Values agronomic traits also have measured. Quantitative trait loci (QTL) height, yield, and maturity were located by their linkage to RFLP QTL controlling amounts variation analyzed the dependence on particular alleles at a second locus comparing cumulative distributions each genotype (four genotypes per pair loci). Interesting pairs statistically with...
Abstract Phenotypic stereotypes are traits, often polygenic, that have been stringently selected to conform specific criteria. In dogs, Canis familiaris, result from breed standards set for conformation, performance (behaviors), etc. As a consequence, phenotypic values measured on few individuals representative of the stereotype. We used DNA samples isolated 148 dog breeds associate SNP markers with stereotypes. Using size as trait test method, we identified six significant quantitative loci...
Evolution of mammalian skeletal structure can be rapid and the changes profound, as illustrated by morphological diversity domestic dog. Here we use principal component analysis variation in a population Portuguese Water Dogs to reveal systems traits defining structures. This classifies phenotypic into independent components that used dissect genetic networks regulating complex biological systems. We show unlinked quantitative trait loci associated with these individually promote both...
Soil waterlogging is a major environmental stress that suppresses soybean [ Glycine max (L.) Merr.] growth and yield. Our objective was to identify quantitative trait loci (QTL) associated with the tolerance of soil waterlogging. We subjected 208 lines two recombinant inbred (RI) populations, ‘Archer’ × ‘Minsoy’ ‘Noir I’, 2 wk when plants were at early flowering stage. The control not flooded. experiment conducted in three environments: Columbus, OH, 1997 1998 Wooster, 1998. identified...
ABSTRACT In order to breed efficiently, it is necessary identify individual quantitative trait loci (QTLs) as well interactions between these and determine which QTLs produce phenotypes that are environment specific. This can be done by linking molecular markers. The objective of this research was carry out such an analysis for yield, one the most complex agronomic traits. To do this, recombinant inbred lines soybean [ Glycine max (L.) Merrill] were characterized genetic markers analyzed...
Size sexual dimorphism occurs in almost all mammals. In Portuguese Water Dogs, much of the difference skeletal size between females and males is due to interaction a Quantitative Trait Locus (QTL) on X-chromosome QTL linked Insulin-like Growth Factor 1 (IGF-1) CFA 15 autosome. females, haplotype resulting small dominant. males, for large Females, homozygous at CHM marker X chromosome are, average, as males. However, that are heterozygous small, regardless their genotype. This suggests...
Traits that have been stringently selected to conform specific criteria in a closed population are phenotypic stereotypes. In dogs, Canis familiaris , such stereotypes produced by breeding for conformation, performance (behaviors), etc. We measured phenotypes on representative sample establish breed DNA samples from 147 dog breeds were used characterize single nucleotide polymorphism allele frequencies association mapping of identified significant size loci (quantitative trait [QTLs]),...
Abstract In dogs hip joint laxity that can lead to degenerative disease (DJD) is frequent and heritable, providing a genetic model for some aspects of the human disease. We have used Portuguese water (PWDs) identify Quantitative trait loci (QTLs) regulate in joint. A population 286 PWDs, each characterized by ca. 500 molecular markers, was analyzed subluxation as measured Norberg angle, quantitative radiographic measure laxity. significant directed asymmetry observed, such greater observed...
Summary Addison's disease, an immune‐mediated disorder caused by destruction of the adrenal glands, is a rare Western European populations. Studies indicate that polygenic in nature, involving specific alleles CTLA‐4, DRB1*04 and DQ, Cyp27B1, VDR MIC‐A ‐B loci. A similar immune form disease occurs several breeds domestic dog, with frequencies ranging from 1.5 to 9.0%. The high frequency dog likely reflects small number founders associated many breeds, subsequent inbreeding, frequent use...
Significance We have used the cellular response to a conopeptide, highly selective K-channel blocker κM-RIIIJ, as initial step in an integrated molecular-, cellular-, and systems-level functional analysis describe characterize six discrete subclasses of large-diameter mouse dorsal-root ganglion neurons. Analysis two these classes (proprioceptors Aδ–low-threshold mechanoreceptors) by current-clamp electrophysiology single-cell transcriptome revealed differences between based on specific...
Abstract Somatostatin and its related peptides (SSRPs) form an important family of hormones with diverse physiological roles. The ubiquitous presence SSRPs in vertebrates several invertebrate deuterostomes suggests ancient origin the SSRP signaling system. However, existence genes outside has not been established, evolutionary history this system remains poorly understood. Our recent discovery SSRP-like toxins (consomatins) venomous marine cone snails (Conus) suggested a mollusks potentially...
Resistance to insects was found in a recombinant inbred (RI) population of soybean derived from nonresistant parents, ‘Minsoy’ and ‘Noir 1’ (MN) (240 RI). The objectives this study were determine quantitative trait loci (QTLs) associated with resistance by linkage either restriction fragment length polymorphism (RFLP) or simple sequence repeat (SSR) markers confirm these new Minsoy crossed the elite cultivar Archer (MA) (233 Corn earworm ( Helicoverpa zea Boddie) larvae reared on individual...
Venom systems are complex traits that have independently emerged multiple times in diverse plant and animal phyla. Within each venomous lineage there typically exists interspecific variation venom composition where several factors been proposed as drivers of variation, including phylogeny diet. Understanding these is broad biological interest has implications for the development antivenom therapies venom-based drug discovery. Because their high species richness presence major evolutionary...