A5023096752- Ion Channels and Receptors
- Quantum Dots Synthesis And Properties
- Neurobiology and Insect Physiology Research
- Luminescence Properties of Advanced Materials
- Ion channel regulation and function
- Radiation Detection and Scintillator Technologies
- Genomics, phytochemicals, and oxidative stress
- Biochemical Analysis and Sensing Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced Semiconductor Detectors and Materials
- Postharvest Quality and Shelf Life Management
- Circadian rhythm and melatonin
- Perovskite Materials and Applications
- X-ray Diffraction in Crystallography
- Burn Injury Management and Outcomes
- Hormonal Regulation and Hypertension
- Herbal Medicine Research Studies
- Chalcogenide Semiconductor Thin Films
- Plant responses to elevated CO2
- Iron oxide chemistry and applications
- Atomic and Subatomic Physics Research
- Magnetic Properties and Synthesis of Ferrites
- Toxin Mechanisms and Immunotoxins
- Pharmacogenetics and Drug Metabolism
- ZnO doping and properties
University of Utah
2012-2024
University of New Mexico
2007-2011
Different types of neurons diverge in function because they express their own unique set or constellation signaling molecules, including receptors and ion channels that work concert. We describe an approach to identify functionally divergent within a large, heterogeneous neuronal population while simultaneously investigating specific isoforms molecules expressed each. In this study we characterized two subclasses menthol-sensitive from cultures dissociated mouse dorsal-root ganglia. Although...
Significance Change in the nervous system occurs response to diverse inputs, both normal and pathological. Defining such changes is required for understanding nervous-system functions pathologies—e.g., from learning memory intractable disease. A unique combination pharmacology strategy allows identification of distinct neuronal subclasses through their constant functional expression a specific subset signaling proteins. Phenotypic alterations one subclass were tracked as function...
We investigated the functional expression of nicotinic acetylcholine receptors (nAChRs) in heterogeneous populations dissociated rat and mouse lumbar dorsal root ganglion (DRG) neurons by calcium imaging. By this experimental approach, it is possible to investigate multiple receptor ion-channel subtypes across more than 100 neuronal glial cells simultaneously. Based on nAChR expression, DRG could be divided into four subclasses: (1) that express predominantly α3β4 α6β4 nAChRs; (2) α7 (3) a...
Transient receptor potential (TRP) cation channels are molecular targets of various natural products. TRPA1, a member TRP channel family, is specifically activated by products such as allyl isothiocyanate (mustard oil), cinnamaldehyde (cinnamon), and allicin (garlic). In this study, we demonstrated that TRPA1 also target <i>trans</i>-anethole in fennel oil (FO) seed extract. Similar to FO, selectively elicited calcium influx TRPA1-expressing mouse sensory neurons the dorsal root trigeminal...
Abstract Mucus hypersecretion is a pathological feature of acute inflammatory and chronic obstructive pulmonary diseases. Exposure to air pollutants can be cause mucus overproduction, but mechanisms by which different forms elicit this response are not fully understood. In study, particulate matter (PM) generated from burning pine wood other types biomass was used determine these PM stimulate mucin gene expression secretion primary human bronchial epithelial cells (HBECs). Biomass &lt;...
Effects of Cs137 gamma irradiation on photoluminescent properties CdSe∕ZnS colloidal quantum dots are reported. Optical degradation is evaluated by tracking the dependence photoluminescence intensity dose. show poor radiation hardness, and severely degrade after less than 20kR exposure to 662keV photons.
Diesel exhaust particulate (DEP) causes pulmonary irritation and inflammation, which can exacerbate asthma other diseases. These effects may arise from the activation of transient receptor potential ankyrin-1 (TRPA1). This study shows that a representative DEP activate TRPA1-expressing C-fibers in mouse lung. Furthermore, collected idling vehicles at an emissions inspection station, tailpipe on-road "black smoker" diesel truck, waste filter regeneration machine, NIST SRM 2975 human TRPA1...
This study investigated the roles of transient receptor potential (TRP) ankyrin-1 (TRPA1) and TRP vanilloid-3 (TRPV3) in regulating endoplasmic reticulum stress (ERS) cytotoxicity human bronchial epithelial cells (HBECs) treated with pneumotoxic wood smoke particulate matter (WSPM) chemical agonists each channel. Functions TRPA1 TRPV3 pulmonary remain largely undefined. shows that activity localizes to plasma membrane (ER) cells, whereas resides primarily ER. Additionally, treatment using...
We report on the successful preparation and characterization of fluorescent magnetic core∕shell Fe(3)O(4)∕ZnSe nanoparticles (NPs) with a spherical shape by organometallic synthesis. The 7 nm core∕3 shell NPs show good photoluminescence (PL) responses. observed PL emission∕excitation spectra are shifted to shorter wavelengths, compared reference ZnSe NP sample. A dramatic reduction quantum yield is also observed. temperature dependence magnetization for shows characteristic features two...
This study tested whether a medicinal plant, Vasaka, typically consumed as tea to treat respiratory malaise, could protect airway epithelial cells (AECs) from wood smoke particle-induced damage and prevent pathological mucus production. Wood/biomass is pneumotoxic air pollutant. Mucus normally protects the airways, but excessive production can obstruct airflow cause distress. Vasaka pre- co-treatment dose-dependently inhibited mucin 5AC (MUC5AC) mRNA induction by AECs treated with particles....
Colloidal synthesis of cerium-doped lanthanum fluoride nanocrystals is reported. The were characterized by transmission electron microscopy, energy-dispersive X-ray spectroscopy, steady-state UV-VIS optical absorption and photoluminescence (PL) PL lifetime measurements. Cerium doping concentration was optimized for the maximum intensity. Radiation hardness synthesized tested using a <sup>137</sup>Cs 662-keV gamma source. Finally, scintillation observed from exposed to low-level radiation.
Prior studies revealed increased expression of the transient receptor potential vanilloid-3 (TRPV3) ion channel after wood smoke particulate matter (WSPM) treatment human bronchial epithelial cells (HBECs). TRPV3 attenuated pathologic endoplasmic reticulum stress and cytotoxicity mediated by ankyrin-1. Here, basis for how is regulated cell injury effects this has on HBEC physiology WSPM-induced airway remodeling in mice was investigated. mRNA rapidly HBECs treated with WSPM monolayer damage...
This study investigated an association between the cytochrome P450 (CYP) 2C8*3 polymorphism with asthma symptom control in children and changes lipid metabolism pro-inflammatory signaling by human bronchial epithelial cells (HBECs) treated cigarette smoke condensate (CSC). CYP genes are inherently variable sequence while such variations known to produce clinically relevant effects on drug pharmacokinetics pharmacodynamics, endogenous substrate associated physiological processes less...
Effects of <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">137</sup> Cs gamma irradiation on photoluminescent properties CdSe/ZnS colloidal quantum dots are reported. Optical degradation was evaluated by measuring dependence photoluminescence intensity dose. show poor radiation hardness.
Marine tunicates produce defensive amino-acid-derived metabolites, including 2-(3,5-diiodo-4-methoxyphenyl)ethan-1-amine (DIMTA), but their mechanisms of action are rarely known. Using an assay-guided approach, we found that out the many different sensory cells in mouse dorsal root ganglion (DRG), DIMTA selectively affected low-threshold cold thermosensors. Whole-cell electrophysiology experiments using DRG cells, channels expressed Xenopus oocytes, and human cell lines revealed blocks...
Properly mixed combination of CdSe/ZnS and CdSe/SiO2 colloidal quantum dots different sizes is suggested as a nanophosphor material to be combined with blue InGaN/GaN LEDs for well-balanced color content white light emission.
Properly mixed combination of CdSe/ZnS colloidal quantum dots different sizes is suggested as a nanophosphor material to be combined with blue InGaN/GaN LEDs for well-balanced color content white light emission.
Lead-iodide-based nanocrystals were synthesized by dissolution of commercial lead iodide powder in a coordinating solvent, tetrahydrofuran, and subsequent re-crystallization after an optimum addition methanol. The characterized transmission electron microscopy, scanning energy dispersive spectroscopy (EDS), steady state UV-visible optical absorption photoluminescence spectroscopy, lifetime quantum efficiency measurements. radiation hardness the material was tested using <sup>137</sup>Cs...
Positron emission tomography requires high-brightness fast-decay scintillators for coincidence counting of positron annihilation events. We demonstrate that LaF <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> :Ce nanocrystals show promising characteristics application. Scintillation response and photoluminescence lifetime below 27 ns are measured.
ABSTRACT Marine tunicates produce defensive amino-acid derived metabolites, including 2-(3,5-diiodo-4-methoxyphenyl)ethan-1-amine (DIMTA), but their mechanisms of action are rarely known. Using an assay-guided approach, we found that out the many different sensory cells in mouse dorsal root ganglion (DRG), DIMTA selectively affected low-threshold cold thermosensors. Whole-cell electrophysiology experiments using DRG cells, channels expressed Xenopus oocytes and human cell lines revealed...