Curcumin is a polyphenolic compound which possesses anticancer potential. It has been shown to induce cell death in variety of cancer cells, however, its effect on CAL27‑cisplatin-resistant human oral cells (CAR cells) not elucidated date. The low water solubility curcumin leads poor bioavailability, highlighted as major limiting factor. In this study, we utilized water-soluble PLGA nanoparticles (Cur-NPs), and investigated the effects Cur-NPs CAR cells. results showed induced apoptosis but...

The aim of the present study was to determine antibacterial activities phenolic essential oil (EO) compounds hinokitiol, carvacrol, thymol, and menthol against oral pathogens. Aggregatibacter actinomycetemcomitans, Streptococcus mutans, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia. coli were used in this study. minimum inhibitory concentrations (MICs), bactericidal (MBCs), bacterial growth curves, temperature pH stabilities, synergistic effects liquid vapor EO tested....

Abstract Phenothiazines (PTZs) have been used for the antipsychotic drugs centuries. However, some of these PTZs reported to exhibit antitumor effects by targeting various signaling pathways in vitro and vivo . Thus, this study was aimed at exploiting trifluoperazine, one PTZs, develop potent agents. This effort culminated A4 [10-(3-(piperazin-1-yl)propyl)-2-(trifluoromethyl)-10 H -phenothiazine] which exhibited multi-fold higher apoptosis-inducing activity than parent compound oral cancer...

Isoliquiritigenin (ISL), a natural compound extracted from licorice, has chemopreventive and antitumor activities. The purpose of this study was to investigate the anticancer effect ISL on human oral squamous cell carcinoma (OSCC).The anti-OSCC effects were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test, flow cytometry, reverse transcription-polymerase chain reaction, Western blotting, promoter activity, terminal deoxynucleotidyl transferase dUTP nick-end...

Honokiol and magnolol are natural components isolated from Magnolia bark that is used in traditional Chinese Japanese herbal medicine. These two isomers as a component of dietary supplements cosmetic products. In this study, we investigated the antimicrobial effect honokiol on pathogens causing oral diseases, their mechanism action biofilm formation drug resistance pathogens, inflammatory regulation mammalian cells. We determined minimum inhibitory concentration bactericidal magnolol,...

Oral squamous cell carcinomas (OSCCs), like several solid tumours, contain heterogeneous subpopulations of a small subset cancer cells, termed stem cells (CSCs), that are highly relevant to metastasis and invasive properties. CSCs have also shown high capacity survive against various stressful environments, such as hypoxia. However, the molecular underpinnings behind potential under this stress remain unclear. The current study aimed investigate significance autophagy systems in oral CSC...

Abstract Background Lysyl oxidase (LOX) is a copper‐dependent enzyme that cross‐links collagen and elastin in the extracellular matrix. LOX overexpressed various tumors. The manner which affects tumor growth remains controversial. Methods Chemical treatment gene transfection were used to induce overexpression or inhibition cell lines SAS SVEC4‐10. mRNA , protein, activity confirmed before tube formation assay tumorigenesis. microvessels section detected by immunostaining CD31‐positive...

Bufalin has been reported to induce apoptosis in a variety of cancers but little is demonstrated oral squamous cell carcinoma (OSCC) cells. The present study investigated the inhibition proliferation, cycle arrest and apoptotic effects bufalin CAL 27 human cancer inhibited growth cells concentration-dependent manner an IC50 value was about 125 nM for 24 h treatment using MTT assay. Moreover, distribution arrested at G0/G1 phase after exposure. Upon stimulation, expression Bcl-2 significantly...

One of the most common malignant tumors head and neck region is tongue cancer. Long noncoding RNAs (lncRNAs) called nuclear enriched abundant transcript 1 (Neat1) are linked to tumor growth, survival, apoptosis in a variety cancer types; however, it unclear how these factors relate Furthermore, unknown Neat1 polymorphisms clinicopathological traits individuals with one another. We looked examined effects three variants gene characteristics on risk 400 male Taiwanese patients who already had...

Abstract Background Ataxia telangiectasia mutated (ATM) regulates DNA repair and cell cycle. The present study analyzed arecoline‐induced ATM expression during oral cancer progression. Methods In vitro studies were performed using squamous carcinoma (OSCC) lines treated with arecoline to analyze response regulation. in vivo immunohistochemistry detect normal, potentially malignant disorder (OPMD), OSCC tissues. Results Low‐dose induced proliferation, promoter activity, repair. High‐dose...

Oral squamous cell carcinoma (OSCC) is a common malignant tumor with poor prognosis and major public health burden in Taiwan. Angiogenesis, the formation of new blood vessels, promotes proliferation, maintenance, metastasis. Angiopoietin 2 (Angpt2), mitogen strong angiogenic effect, highly specific to endothelial cells key player angiogenesis. The inflammatory chemokine (C-C motif) ligand 4 (CCL4) also important pathogenesis progression cancer. In this study, an analysis records from Cancer...

Patients are always concerned about their postoperative appearance before surgery for facial deformity correction. The present study investigated the profile and frontal changes following two-jaw surgery.Forty patients who underwent were divided by amount of mandibular setback (group I: ≤8 mm group II: >8 mm). Cephalometric radiograms (lateral frontal) collected analyzed at three intervals: preoperatively (T1), immediately postoperatively (T2), final follow-up (T3). points identified: cheek...

Oral cancer is the eighth greatest generally diagnosed amongst males worldwide and fourth most malignancy Taiwanese males.The pro-inflammatory adipocytokine visfatin promotes tumor growth.Elevated plasma levels have been identified in patients with oral squamous cell carcinoma (OSCC), although biological mechanisms underlying involvement of pathogenesis OSCC are not well understood.Moreover, no information available regarding associations between polymorphisms carcinogenic lifestyle factors...

Dislocation of the mandibular condyle is one several consequences facial trauma that can be anticipated. The condylar neck inherently weak and likely to fracture at time impact before dislocating into middle cranial fossa. A review literature revealed most cases dislocation fossa are treated by open reduction internal fixation via an extraoral approach or conservatively with closed reduction. An intraoral rare. Here we present a patient traumatic who was successfully condylectomy...

Abstract Background Use of proximal tibia as a donor site has been applied in jawbone reconstruction since the 1990s. Catone and colleagues described U ‐shaped incision made on iliotibial tract during tibial cancellous bone procurement for maxillofacial 1992. We used curvilinear lateral approach our harvesting procedure. Objectives The objectives this retrospective study are to describe modified procuring graft from assess volume, morbidity, associated complications. Material Methods Eighty...

Background . This study investigates the differences in lateral profile and frontal appearance after sagittal split ramus osteotomy (SSRO) intraoral vertical (IVRO) procedures for correction of mandibular prognathism. Methods Sixty patients (30 SSRO 30 IVRO) underwent setback surgery. Serial cephalograms were obtained: (1) T1: approximately 1 month before surgery; (2) T2: at least 6 months surgery year IVRO. The landmarks, linear distances, related angles measured. t -test was applied to...

The purpose of the present study was to investigate improvements facial profile and postoperative stability by single mandibular setback surgery.The included twenty-seven patients who underwent prognathism correction sagittal split ramus osteotomy (SSRO). Cephalometric radiograms (lateral frontal) were collected analyzed at three intervals: preoperatively (T1), immediately postoperatively (T2), final follow-up (T3). lateral frontal cephalometric parameters measured. immediate change (T21),...

Abstract Purpose: Oral squamous cell carcinoma (OSCC) significantly impacts public health with its high occurrence and grim outcomes. Platinum resistance complicates OSCC treatment. Yes-associated protein (YAP) plays a key role in development, while circular RNA (circRNA) influences microRNA activity, contributing to chemoresistance cancers. Yet, how circRNA affects YAP expression is unclear. Methods: We examined the of 21 newly diagnosed cases using immunohistochemistry quantitative...

The aim of this study was to determine changes in the tongue area and pharyngeal airway space (PAS) after intraoral vertical ramus osteotomy (IVRO).Serial lateral cephalograms 40 patients with mandibular prognathism who underwent IVRO were evaluated before (T1), immediately (T2), more than 1 year (T3) surgery. Paired t-tests Pearson's correlation analysis used evaluate postoperative mandible, nasopharyngeal (NOP), retropalatal (RPP), retroglossal (RGP), hypopharyngeal (HOP), PAS, (TA). null...

Virtual planning software and three-dimensional printing technology have improved the operation time surgical accuracy.We performed partial mandibulectomy reconstruction via intraoral approach with relatively acceptable clinical results in two patients ameloblastoma.Preoperative preparations were full skull computed tomography, virtual cuttings, pre-bent load-sharing titanium plates that conformed to additive stereolithographic models, complex computer-aided design/computer-assisted...