A5079544440- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Nerve injury and regeneration
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Nerve Injury and Rehabilitation
- Signaling Pathways in Disease
University of Florida
2018-2024
Decellularized peripheral nerve has been proven to be an effective clinical intervention for repair and a preclinical cell carrier after spinal cord injury. However, there are currently lack of decellularization methods that remove cells maintain matrix similar the previously established, clinically translated technique (the Hudson method) relies on discontinued Triton X-200 detergent. Therefore, aim this study was optimize novel chemical method nerves based available anionic detergent...
Damage to the nervous system can result in loss of sensory and motor function, paralysis, or even death. To facilitate neural regeneration functional recovery, researchers have employed biomaterials strategies address both peripheral central injuries. Injectable hydrogels that recapitulate native nerve extracellular matrix are especially promising for tissue engineering because they offer more flexibility minimally invasive applications provide a growth-permissive substrate cell types. Here,...
To develop a clinically relevant injectable hydrogel derived from decellularized porcine peripheral nerves and with mechanical properties comparable to native central nervous system (CNS) tissue be used as delivery vehicle for Schwann cell transplantation treat spinal cord injury (SCI).