A5023361808- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
- Additive Manufacturing and 3D Printing Technologies
- Micro and Nano Robotics
- Cancer Cells and Metastasis
- Elasticity and Material Modeling
- Manufacturing Process and Optimization
- Collagen: Extraction and Characterization
- Rheology and Fluid Dynamics Studies
- Heat shock proteins research
- Tissue Engineering and Regenerative Medicine
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Nerve injury and regeneration
- Innovative Microfluidic and Catalytic Techniques Innovation
- CAR-T cell therapy research
- Microfluidic and Bio-sensing Technologies
- Force Microscopy Techniques and Applications
- Soft Robotics and Applications
- Modular Robots and Swarm Intelligence
- Molecular Communication and Nanonetworks
- Mesenchymal stem cell research
- Tendon Structure and Treatment
- Mechanical and Optical Resonators
University of California, Berkeley
2022-2024
University of Florida
2019-2022
Gainesville Obstetrics & Gynecology
2019-2020
MVJ College of Engineering
2020
With improving biofabrication technology, 3D bioprinted constructs increasingly resemble real tissues. However, the fundamental principles describing how cell-generated forces within these drive deformations, mechanical instabilities, and structural failures have not been established, even for basic biofabricated building blocks. Here we investigate behaviours of printed microbeams made from living cells extracellular matrix, bioprinting simple elements into a culture medium packed...
The recent attention given to functionalities that respond mechanical force has led a deeper understanding of transduction and wear in polymeric materials. Furthermore, polymers have been carefully designed such activation "mechanophores" leads productive outputs, as material reinforcement or changes optical properties. In this work, crosslinker containing an anthracene-maleimide linkage was used prepare networks display fluorescence response when damaged. pressure-dependent damage...
Injectable hydrogels are increasingly explored for the delivery of cells to tissue. These materials exhibit both liquid-like properties, protecting from mechanical stress during injection, and solid-like providing a stable 3D engraftment niche. Many strategies modulating injectable tune liquid- material properties simultaneously, such that formulation changes designed improve injectability can reduce stability at site. The ability independently would greatly facilitate development. Here,...
Damage to the nervous system can result in loss of sensory and motor function, paralysis, or even death. To facilitate neural regeneration functional recovery, researchers have employed biomaterials strategies address both peripheral central injuries. Injectable hydrogels that recapitulate native nerve extracellular matrix are especially promising for tissue engineering because they offer more flexibility minimally invasive applications provide a growth-permissive substrate cell types. Here,...
Biomaterials that can be reversibly stiffened and shaped could useful in broad biomedical applications where form-fitting scaffolds are needed. Here we investigate the combination of strong non-linear elasticity biopolymer networks with reconfigurability packed hydrogel particles within a composite biomaterial. By packing microgels into collagen-1 characterizing their linear material properties, empirically determine scaling relationship describes synergistic dependence material's elastic...
In both natural and applied contexts, investigating cell self-assembly aggregation within controlled 3D environments leads to improved understanding of how structured assemblies emerge, what determines their shapes sizes, whether structural features are stable.
Organoids are powerful models of tissue physiology, yet their applications remain limited due to relatively simple morphology and high organoid-to-organoid structural variability. To address these limitations we developed a soft, composite yield-stress extracellular matrix that supports optimal organoid morphogenesis following freeform 3D bioprinting cell slurries at tissue-like densities. The material is designed with two temperature regimes: 4 °C it exhibits reversible behavior support...
Abstract Soft materials such as hydrogels and elastomers exhibit very low stiffness strength well large deformations, which makes their mechanical characterisation extremely difficult through conventional methods. This paper presents a novel experimental technique for the shear property of these materials. Agarose were chosen model material this study. The new in‐plane test method incorporates 3‐D‐printed acrylonitrile butadiene styrene (ABS) grips specimen mounting digital image correlation...
INTRODUCTION: The survival benefit of adoptive cellular therapy is significantly enhanced by concomitant transfer bone marrow derived hematopoietic stem cells (HSC) with tumor-reactive T in two preclinical models brain glioma (BSG), OB1 (wildtype H3.3), and K2 (H3.3K27M mutation). Using a novel method 3D printing to fabricate microtumors using BSG cells, we interrogate tumor microenvironment directly demonstrate that the presence HSC-derived increases cell velocity migration tumor, increased...