A5012664818- Genetics, Aging, and Longevity in Model Organisms
- Telomeres, Telomerase, and Senescence
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Cancer Diagnosis and Treatment
- Muscle Physiology and Disorders
- Cellular Mechanics and Interactions
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Prostate Cancer Treatment and Research
Inserm
2023-2024
Université Côte d'Azur
2023-2024
Institut de Recherche sur le Cancer et le Vieillissement de Nice
2023-2024
Centre National de la Recherche Scientifique
2023-2024
University of California, San Francisco
2024
Telomere shortening is a hallmark of aging and counteracted by telomerase. As in humans, the zebrafish gut one organs with fastest rate telomere decline, triggering early tissue dysfunction during normal prematurely aged telomerase mutants. However, whether telomere-dependent an individual organ, gut, causes systemic unknown. Here we show that tissue-specific expression can prevent rescues premature tert-/-. Induction senescence low cell proliferation, while restoring integrity, inflammation...
Organoids are powerful models of tissue physiology, yet their applications remain limited due to relatively simple morphology and high organoid-to-organoid structural variability. To address these limitations we developed a soft, composite yield-stress extracellular matrix that supports optimal organoid morphogenesis following freeform 3D bioprinting cell slurries at tissue-like densities. The material is designed with two temperature regimes: 4 °C it exhibits reversible behavior support...
Abstract Most cancers reactivate telomerase to maintain telomere length acquire immortality. The importance of this process is well illustrated by the fact that promoter mutations are found at a high frequency in many cancer types, including melanoma. However, it unclear when and if strictly required during tumorigenesis. Here, we show melanoma can occur absence but sustain later growth avoid tumor regression. We combined mutant zebrafish ( tert-/- ) with two established models equal...
Abstract Overtreatment of prostate cancer is a significant source patient morbidity and cost. The human bounded by smooth muscle capsule, aggressive tumors invade through the layer, called extracapsular extension (ECE), to escape organ confinement. presence ECE defines pT3a pathologic stage associated with increased risk biochemical recurrence, metastases, cancer-specific mortality. Although invasion required for metastatic spread, both invasive tumor network phenotypes responses are...