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Junghoon Lee

ORCID: 0000-0003-0013-6912
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About
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A5012745961
Research Areas
  • Cholesterol and Lipid Metabolism
  • Lipid Membrane Structure and Behavior
  • Protein Degradation and Inhibitors
  • Genetic and Kidney Cyst Diseases
  • Fetal and Pediatric Neurological Disorders
  • Lipoproteins and Cardiovascular Health
  • Dendrimers and Hyperbranched Polymers
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Genomic variations and chromosomal abnormalities

Dartmouth College
 2021-2024

 Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamics
OPENALEX - Publications 
Tyrone DeSpenza Amrita Singh Garrett Allington Shujuan Zhao Junghoon Lee and 27 more Emre Kiziltug Mackenzi L. Prina Nicole M. Desmet Huy Dang Jennifer Fields Carol Nelson‐Williams Junhui Zhang Kedous Y. Mekbib Evan Dennis Neel H. Mehta Phan Q. Duy Hermela Shimelis Lauren K. Walsh Arnaud Marlier Engin Deniz Evelyn M. R. Lake R. Todd Constable Ellen J. Hoffman Richard P. Lifton Allan T. Gulledge Steven Fiering Andrés Moreno-De-Luca Shozeb Haider Seth L. Alper Sheng Chih Jin Kristopher T. Kahle Bryan W. Luikart

Enlargement of the cerebrospinal fluid (CSF)-filled brain ventricles (cerebral ventriculomegaly), cardinal feature congenital hydrocephalus (CH), is increasingly recognized among patients with autism spectrum disorders (ASD).

10.1073/pnas.2314702121 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2024-06-25
 Blocking cholesterol storage to treat Alzheimer’s disease
OPENALEX - Publications 
Ta‐Yuan Chang Catherine C.Y. Chang Taylor C. Harned Adrianna L. De La Torre Junghoon Lee and 2 more Thao N. Huynh James G. Gow

Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites cholesterol also play important functions. Acyl-coenzyme A: acyltransferase 1 (ACAT1), named sterol

10.37349/ent.2021.00014 article EN cc-by Exploration of Neuroprotective Therapy 2021-12-30
 Characterization of Stealth Liposome-Based Nanoparticles Encapsulating the ACAT1/SOAT1 Inhibitor F26: Efficacy and Toxicity Studies In Vitro and in Wild-Type Mice
OPENALEX - Publications 
Junghoon Lee Adrianna L. De La Torre Felix L. Rawlinson Dylan B. Ness Lionel D. Lewis and 3 more William F. Hickey Catherine C.Y. Chang Ta‐Yuan Chang

Cholesterol homeostasis is pivotal for cellular function. Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1), also abbreviated as SOAT1, an enzyme responsible catalyzing the storage of excess cholesterol to cholesteryl esters. ACAT1 emerging target treat diverse diseases including atherosclerosis, cancer, and neurodegenerative diseases. F12511 a high-affinity inhibitor. Previously, we developed stealth liposome-based nanoparticle encapsulate enhance its delivery brain showed efficacy in...

10.3390/ijms25179151 article EN International Journal of Molecular Sciences 2024-08-23
 Characterization of Stealth Liposome-Based Nanoparticles Encapsulating the ACAT1/SOAT1 Inhibitor F26: Efficacy and Toxicity Studies In Vitro and in Wild-Type Mice
OPENALEX - Publications 
Junghoon Lee Adrianna L. De La Torre Felix L. Rawlinson Dylan B. Ness Lionel D. Lewis and 3 more William F. Hickey Catherine C.Y. Chang Ta‐Yuan Chang

Cholesterol homeostasis is pivotal for cellular function. Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1), also abbreviated as SOAT1, an enzyme catalyzing the storage of excess cholesterol to cholesteryl esters. ACAT1 emerging target treat diverse diseases including atherosclerosis, cancer, and neurodegenerative diseases. F12511 a high affinity inhibitor. Previously, we developed stealth liposome-based nanoparticle encapsulate enhance its delivery brain showed efficacy in treating...

10.20944/preprints202407.2417.v1 preprint EN 2024-07-30
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