A5103234255- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Sperm and Testicular Function
- Reproductive System and Pregnancy
- Reproductive Health and Technologies
- RNA Interference and Gene Delivery
- Alzheimer's disease research and treatments
- Growth Hormone and Insulin-like Growth Factors
- Cardiac electrophysiology and arrhythmias
- Pharmaceutical Practices and Patient Outcomes
- Pharmacological Effects and Toxicity Studies
- Electrospun Nanofibers in Biomedical Applications
- Stress Responses and Cortisol
- Menopause: Health Impacts and Treatments
- Wound Healing and Treatments
- Surface Treatment and Coatings
- Oral health in cancer treatment
- Hypothalamic control of reproductive hormones
- Infectious Aortic and Vascular Conditions
- Foreign Body Medical Cases
- Genetic and rare skin diseases.
- Hemostasis and retained surgical items
- Silk-based biomaterials and applications
Osaka University
2013
Soma Central Hospital
2010
Nagoya University
1995-2009
Tokushima Breast Care Clinic
2006
Meijo University
2003
Nagoya University Hospital
1995-2003
Ehime University
1983-1993
Nagasaki University
1983-1992
Basic fibroblast growth factor (bFGF) has been shown to stimulate wound healing. However, consistent delivery of bFGF problematic. We studied the stability incorporated into a chitosan film as vehicle for providing sustained release bFGF. The therapeutic effect this system on healing in genetically diabetic mice was determined model treating clinically impaired A prepared by freeze-drying hydroxypropylchitosan (a water-soluble derivative chitosan) acetate buffer solution. Growth films before...
Objective Assisted reproductive technology (ART), especially frozen–thawed embryo transfer (FET) in a hormone replacement cycle (HRC), is risk factor for placenta accreta spectrum (PAS). This study aimed to clarify the factors PAS related maternal background and ART techniques pregnancies achieved after FET an HRC. Study Design We performed case–control two tertiary perinatal centres Japan. Among 14,028 patients who delivered at ≥24 weeks of gestation or were transferred delivery between...
In the present study, we examined whether deprivation of oestrogens by ovariectomy could modify learning and memory deficits caused a continuous intracerebroventricular (i.c.v.) infusion amyloid β‐peptide (Aβ), major constituent senile plaques in AD. Neither long‐term (3 months) nor short‐term (1 month), significant impairment spatial water maze spontaneous alternation behaviour Y‐maze. A i.c.v. Aβ‐(1‐42) both ovariectomized sham‐operated rats. The Aβ‐induced working were significantly...
In vitro and in vivo studies were conducted to gauge the effectiveness of a novel oral mucosa adhesive, moderately water-soluble, pliant polymer artificial dentifrice (AD) film containing dibucaine (DC) for relief pain due erosion. The was prepared from hydroxypropyl cellulose-M (HPC-M) ethanol solution varying amounts DC, as well polyethylene glycol. experiments, disintegration HPC-M showed lag time about 50 min, much lower rate than that drug release, which more or less leveled off after...
Afternoon-evening and nocturnal serum PRL levels responsiveness to metoclopramide (MCP) were determined in 34 women with normoprolactinemic anovulation (nPRL-Anov) the early follicular phase (EFP) 6 normal women. Subsequently, nPRL-Anov treated 5 mg bromocriptine (Br) twice daily for 2 months, its action on ovulation was determined. Those who did not respond Br received 50–150 clomiphene days. The patients classified into 3 groups terms of efficacy treatment: group I, those ovulated (n =...
We investigated whether or not fibrin glue (FG) used as a sealant in vascular prostheses to prevent leakage might be useful carrier of antibiotics for the prevention local graft infection. Sisomicin (SISO) was incorporated into (SISO-FG) and evaluated its safety pharmacokinetics. SISO (1.75 mg) -FG Dacron grafts were implanted subcutaneously anterior abdominal region Sprague-Dawley rats, then changes concentrations serum tissue around implantation sites compared with those same rats that had...
Is oocyte cryopreservation an applicable option for fertility preservation in unmarried patients with haematological malignancies?
To evaluate the latent risk of acidosis in commercially available total parenteral nutrition (TPN) products, three types TPN products were compared postoperative patients. Sixty-four hospitalized patients with gastro-intestinal disease who undertook curative gastro intestinal resection studied prospectively and administered solutions. Three assigned randomly to eligible Serial studies blood acid-base status, serum electrolytes, urinary status conducted groups different Patients received...
We designed a model vascular prosthesis consisting of expanded polytetrafluoroethylene (Gore Tex) loaded with basic fibroblast growth factor (bFGF), and studied its in vivo bFGF release behavior. To control the rate bFGF, biodegradable hydroxypropylchitosan acetate (HPCHA) was also incorporated into Gore Tex disks bFGF. HPCHA dissolved solution (180 micrograms/ml) at concentration 4% (wt/vol). A tube cut length about 5 cm one end sealed clamp. The then filled resulting under appropriate...
Forskolin (FK), a diterpenoid isolated from Coleus Forskohlii, underwent base-catalyzed hydrolysis, producing 7-deacetyl forskolin. The half-life at pH 7.0 and 25°C was 16 d. Because of its poor solubility in water degradation, the drug incorporated lipid emulsions (soybean oil/water=10.9/89.1 v/v, average diameter droplets, 204 nm). No degradation found emulsion up to 30 distribution FK investigated based on three-phase model which assumes that resides oil phases oil/water interface. From...
It is known that continuous stimulation with LHRH induces a biphasic release of LH. The two pools theory generally accepted in interpreting this phenomenon. present study was conducted order to elicit qualitative differences LH included the pools.Five hundred μg synthetic infused for 2h 10 women various phases menstrual cycle and 5h blood sampling performed during after infusion. Biphasic demonstrated all cases investigated. responsiveness most predominant midcycle, followed by luteal phase....
Aim: We assessed the effectiveness of assisted hatching using a 1.48-µm diode laser in human embryos, comparing zona opening and thinning techniques. Methods: A total 56 day 3 embryos were assigned randomly to group, or control group. then carried out OCTAX Laser Shot system (MTG Medical Technology, Altdorf, Germany) first two groups. In inner membrane pellucida was broken create full-thickness opening. not breached. After procedure, cultured hatched blastocyst stage. Results: Blastocyst...
Abstract To examine the efficacy of sisomicin (SISO) incorporated into fibrin glue (FG) for prevention graft infection in animal models, susceptibility to Dacron grafts (control) and SISO‐FG following inoculation Staphylococcus aureus or S. epidermidis was compared. The results showed that displayed resistance infection.
In order to carry out effective warfarin treatment and avoid unnecessary adverse reactions, patients need recognize the importance of drug compliance, food-drug interaction, drug-drug matters that require attention in daily life. We therefore have conducted a “Warfarin Classroom” since April 2000 provide proper information about outpatients. evaluated how did changed both knowledge recognition these using scoring system. The number subjects participating this study was 136 (110 males, 26...
In the embryos made by assisted reproductive technology (ART), hatching has been frequently inhibited hardening of zona pellucida due to in vitro culture. Assisted (AH) is a technique promote embryo breaching part using mechanical or chemical method. Laser technologies became increasingly common for manipulation. (LAH) an important support ART.
Twenty-six anovulatory women of polycystic ovarian (PCO)-type were treated with bromocriptine (Br) at a daily dose 5 mg for 2 months. Ovulatory cycles resumed in 18 (69.2%) (Br-responders). No difference between pretreatment serum levels FSH, LH, PRL and estradiol FSH/LH ratios Br-responders nonresponders was observed. The geometric mean circulating androstenedione (A-dione) (2.58 ng/ml) appeared higher than that (2.11 but not statistically significant. dehydroepiandtrosterone sulfate...
The aim of the present study was to assess efficacy laser assisted hatching (LAH) in human embryos. Embryos were assigned one two groups: LAH group (n=24) or control (n=19). In group, zona opening performed at day 3 embryo with use a 1.48-μm infrared diode (OCTAX Laser Shot™ system, MTG Medical Technology, Altdorf, Germany). Following LAH, embryos cultured up blastocyst stage determine whether resulted damage subsequent development. on 14 patients who experienced IVF/ICSI failures more...
Ten women of polycystic ovarian-type (PCO-type) anovulation, having a decreased ratio FSH to LH and androgen excess, resistant the previous clomiphene, bromocriptine and/or daily im injections human menopausal gonadotropine (hMG), were treated with continuous sc infusion 150 IU/day hMG. The treatment was initiated on cycle day 2-5 continued until dominant follicle reached 20mm or more in diameter, when an bolus 10, 000 IU chorionic gonadotropin given. elevated geometric mean pretreatment...