A5100761995- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- Luminescence and Fluorescent Materials
- Histone Deacetylase Inhibitors Research
- Advanced Nanomaterials in Catalysis
- Advanced Biosensing Techniques and Applications
- Peptidase Inhibition and Analysis
- Nanoplatforms for cancer theranostics
- Protein Degradation and Inhibitors
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Advanced Battery Technologies Research
- Synthetic Organic Chemistry Methods
- Advanced Battery Materials and Technologies
- Adsorption and Cooling Systems
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
- Advanced Chemical Sensor Technologies
- Chemical Synthesis and Analysis
- Cancer-related molecular mechanisms research
- Catalytic Alkyne Reactions
- Anodic Oxide Films and Nanostructures
- Phase Change Materials Research
- Catalytic C–H Functionalization Methods
Nanchang University
2019-2025
State Key Laboratory of Food Science and Technology
2019-2025
Jiangxi Academy of Sciences
2023-2025
Second Affiliated Hospital of Nanchang University
2024
Southeast University
2024
University of Colorado Anschutz Medical Campus
2020-2023
University of Colorado Cancer Center
2023
Guangzhou Institute of Geochemistry
2023
University of Colorado Denver
2023
Huaibei Normal University
2023
Escherichia coli O157:H7 (E. O157:H7) has become one of the major threats to public health and food safety. However, culture method as a gold standard for detection E. requires laborious operations long processing time. Herein, we developed dual-readout aggregation-induced emission nanoparticle-based lateral flow immunoassay (LFIA) sensitive achieve qualitative quantitative assay satisfying applications under varying scenarios. 2,3-Bis(4-(bis(4-(tert-butyl)phenyl)amino)phenyl)fumaronitrile...
The application of traditional lateral flow immunoassay (LFIA)-based gold nanoparticles (AuNPs) to measure traces target chemicals is usually challenging. In this study, we developed an integrated strategy based on molecular engineering and the spatial confinement (NPs) obtain ultrahigh quantum yields (QYs) aggregation-induced emission (AIE) fluorescence NPs employed them for highly sensitive detection T-2 toxin LFIA platform. Tetraethyl-4,4′,4″,4‴-(ethene-1,1,2,2-tetrayl)tetrabenzoate...
Abstract Gold nanoparticles (AuNPs), universally regarded as colorimetric signal reporters, are widely employed in lateral flow immunoassays (LFIAs). However, it is difficult for AuNPs‐LFIA to achieve a wide range and sensitive detection. Herein, novel coral‐like hollow gold nanospheres (CHGNPs) synthesized. The growth of can be regulated obtain multibranched construction. obtained CHGNPs possess intense broadband absorption across the visible near‐infrared region, exhibiting high molar...
Abstract Background and Aim Long intergenic noncoding RNAs (lincRNAs) have critical roles in elevating efficacy of anticancer therapy tumor progression. Recent studies show that Regulator Reprogramming (ROR) is aberrantly expressed several types cancer, including colorectal cancer (CRC). Radiotherapy considered as a standard preoperative treatment. However, considerable number CRCs are resistant to radiotherapy. In this study, we evaluated the role lincRNA‐ROR radiotherapy for CRC detected...
Conventional fluorescent microspheres (CFMs) have the disadvantages of low photoluminescence intensity (aggregation-caused quenching) and poor antibody conjugation. Herein, we achieved improved performance lateral flow immunoassay (LFIA) based on high-fluorescent property aggregation-induced emission (AIEFMs) biofriendly coupling strategy polydopamine (PDA) layer. Although PDA layer quenches fluorescence AIEFM by Förster resonance energy transfer (FRET), quenching can be effectively...
The label with a large Stokes shift and strong fluorescence properties could improve the sensitivity of lateral flow immunoassay (LFIA). Herein, two aggregation-induced emission (AIE) luminogens spectral overlap were encapsulated in polymers by using microemulsion method as label, construction resonance energy transfer mode was further verified via theoretical calculation analysis. Satisfactorily, doped AIE polymer microspheres (DAIEPMs) exhibited 285 nm 10.8-fold enhancement compared to...
An ammonium acetate assisted gold-catalyzed cascade cyclization reaction of 2-alkynylarylketones is described. Under the reported conditions, a intramolecular takes place through two competing mechanisms-a 5-exo-dig or 6-endo-dig cyclization-leading to regioisomeric intermediates: isobenzofuranium isobenzopyrylium. In presence acetate, intermediate compounds undergo further rearrangement 2,3-disubstituted indenones and 1,3-disubstituted isoquinolines, respectively. While both pathways...
Flow and heat transfer of aqueous based silica alumina nanofluids in microchannels were experimentally investigated. The measured friction factors higher than conventional model predictions at low Reynolds numbers particularly with high nanoparticle concentrations. A decrease the factor was observed increasing number, possibly due to augmentation aggregate shape arising from fluid shear alteration local concentration nanofluid viscosity. Augmentation morphology by may also have affected...
PD1 blockade is effective in a subset of patients with B-cell lymphoma (e.g., classical-Hodgkin lymphomas); however, most do not respond to anti-PD1 therapy. To study resistance, we used an isoform-selective histone deacetylase inhibitor (HDACi; OKI-179), and mouse mature lymphoma, G1XP immunosuppressive features which resemble those human lymphomas, including downregulation MHC class I II, exhaustion CD8+ CD4+ tumor-infiltrating lymphocytes (TIL), PD1-blockade resistance. Using two models,...
Protein ubiquitination plays an important role in the regulation of almost every aspect eukaryotic cellular function; therefore, its destabilization is often observed most human diseases and cancers. Consequently, developing inhibitors system for treatment cancer has been a recent area interest. Currently, only few classes compounds have discovered to inhibit ubiquitin-activating enzyme (E1) one class relatively selective E1 inhibition cells. We now report that Largazole ester ketone analogs...
Decreased levels of cell cycle inhibitor p27(Kip1) due to excessive degradation occur in a variety aggressive human tumors. Since reduced expression has been associated with poor prognosis many cancers and resistance certain antitumor therapies, elevation could improve prevent proliferation. SCF(Skp2) is one the major ubiquitin E3 ligases responsible for p27(Kip1). Ubiquitination also requires small adaptor protein, Cks1, which facilitates substrate recruitment by bridging interaction...
Pathogenic diseases that trigger food safety remain a noteworthy concern due to substantial public health, economic, and social burdens worldwide. It is vital for developing an integrated diagnosis treatment strategy bacteria, which could achieve quick detection of pathogenic bacteria the inhibition multidrug-resistant bacteria. Herein, we reported organic molecule (M-3) possessed strong light capture capacity, emerging low energy gap ΔEST. Subsequently, M-3 was into nanostructured system...