A5031082473- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Computational Drug Discovery Methods
- Genetic Mapping and Diversity in Plants and Animals
- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Statistical Methods and Inference
- Advanced Cellulose Research Studies
- Fiber-reinforced polymer composites
- Gene Regulatory Network Analysis
- Biosensors and Analytical Detection
- biodegradable polymer synthesis and properties
- Machine Learning in Bioinformatics
- Advanced biosensing and bioanalysis techniques
- Advanced Sensor and Energy Harvesting Materials
- Metabolomics and Mass Spectrometry Studies
- Single-cell and spatial transcriptomics
- Face and Expression Recognition
- Perovskite Materials and Applications
- Bayesian Modeling and Causal Inference
- RNA Research and Splicing
- Natural Fiber Reinforced Composites
- Entrepreneurship Studies and Influences
- Family Business Performance and Succession
- Microbial Metabolic Engineering and Bioproduction
Nanjing Normal University
2024-2025
Affiliated Hospital of Taishan Medical University
2025
Shandong First Medical University
2025
Wuhan Textile University
2021-2024
Shanghai University of Finance and Economics
2015-2024
Jiangsu University
2017-2024
State Key Laboratory of Food Science and Technology
2023
Shanghai Lixin University of Accounting and Finance
2023
Nanchang University
2023
National Taiwan University
2023
Recently, several studies have drawn attention to the determination of a minimum set driver proteins that are important for control underlying protein-protein interaction (PPI) networks. In general, dominating (MDS) model is widely adopted. However, because MDS does not generate unique configuration, multiple different MDSs would be generated when using optimization algorithms. Therefore, among these MDSs, it difficult find out one represents true proteins.To address this problem, we develop...
Biomarker identification and cancer classification are two closely related problems. In gene expression data sets, the correlation between genes can be high when they share same biological pathway. Moreover, sets may contain outliers due to either chemical or electrical reasons. A good selection method should take group effects into account robust outliers. this paper, we propose a Laplace naive Bayes model with mean shrinkage (LNB-MS). The distribution instead of normal is used as...
Abstract Previous study found that the solvent extraction efficiency of lipid in microalgae could be greatly improved by washing algae cells before second time extraction. Based on "organic solvents–water–organic solvents" method, this research further studied effect four systems (acetone, chloroform/methanol, chloroform/methanol/water, dichloromethane/methanol), two types water treatment (vortex and ultrasonic), three gradient (0 s, 30 120 s) at different growth stages (3rd day, 5th 9th...
Melamine (MEL), enrofloxacin (ENR), sulfamethazine (SMZ), tetracycline (TC), and aflatoxin M1 (AFM1) are the main chemical contaminants in milk. It is necessary to detect these miscellaneous milk synchronously ensure safety of In this study, a multiple lateral flow immunoassay (LFIA) was developed for detection MEL, ENR, SMZ, TC, AFM1 Under optimal experimental conditions, cutoff values were 25 ng/mL 1 2.5 0.25 samples. The limits LFIA 0.173 0.078 0.059 0.082 0.0064 AFM1. recovery rates...
Protein-ligand docking is widely applied to structure-based virtual screening for drug discovery. This article presents a novel technique, PRL-Dock, based on hydrogen bond matching and probabilistic relaxation labeling. It deals with multiple bonds can match many acceptors donors simultaneously. In the process, initial probability of an acceptor donor estimated by efficient scoring function compatibility coefficients are assigned according coexisting condition two bonds. After matching,...
For the etiology, progression, and treatment of complex diseases, gene-environment (G-E) interactions have important implications beyond main G E effects. G-E interaction analysis can be more challenging with higher dimensionality need for accommodating "main effects, interactions" hierarchy. In recent literature, an array novel methods, many which are based on penalization technique, been developed. most these studies, however, structures measurements, example, adjacency structure single...
Simultaneous contamination of ochratoxin A (OTA) and aflatoxin B1 (AFB1) in cereals are an ongoing global concern. For this reason, a sensitive method for the simultaneous detection OTA AFB1 soybean, corn, rice is required. Herein, we prepared bispecific monoclonal antibody (BsMAb) that specifically recognized AFB1, subsequently developed quantum dot nanobead (QB) lateral flow immunoassay (QB-LFIA) based on BsMAb. The half-inhibitory concentrations (IC50) were 0.73 0.01 µg/kg 1.14 0.03 1.69...
An electrochemical protocol for the alkylation of imines was developed by using easily available alkyl halides as sources, graphite felt (GF) anode and zinc plate cathode. Various substituted imines, bromides iodides were suitable this reaction a series α‐branched amines obtained in moderate to good yields. This method provides green way addition avoid need metal reagents, chemical oxidants reductants, which makes it has application prospect drug synthesis.
The efficient construction of a C-S bond is one the important topics in organic synthesis. In this work, cross-dehydrogenative coupling reaction between ether and thiophenols or thiols under electrochemical conditions was studied, acetal-O,S products were obtained moderate to good yields. A free radical mechanism proposed. provided simple protocol for formation C(sp3)-S bonds transition-metal- chemical oxidant-free conditions, will have application prospect synthesis drug
ABSTRACT Enzyme encapsulation is a simple, gentle, and general method for immobilizing enzyme, but it often suffers from one or more problems regarding enzyme loading efficiency, leakage, mechanical stability, recyclability. Here we report novel, efficient to overcome these by forming stable organic–inorganic hybrid capsules. A new, facile, one‐step, template‐free synthesis of capsules in aqueous phase were developed based on PEI‐induced simultaneous interfacial self‐assembly Fmoc‐FF...
In cancer biology, it is very important to understand the phenotypic changes of patients and discover new subtypes. Recently, microarray-based technologies have shed light on this problem based gene expression profiles which may contain outliers due either chemical or electrical reasons. These undiscovered subtypes be heterogeneous with respect underlying networks pathways, are related only a few interdependent biomarkers. This motivates need for robust expression-based methods capable...
Gene-gene (G×G) interactions have been shown to be critical for the fundamental mechanisms and development of complex diseases beyond main genetic effects. The commonly adopted marginal analysis is limited by considering only a small number G factors at time. With "main effects, interactions" hierarchical constraint, many existing joint methods suffer from prohibitively high computational cost. In this study, we propose new method identifying important G×G under modeling. proposed adopts...
Cancer prognosis is of essential interest, and extensive research has been conducted searching for biomarkers with prognostic power. Recent studies have shown that both omics profiles histopathological imaging features There are also exploring integrating the two types measurements modeling. However, there a lack study rigorously examining whether independent power conditional on features, vice versa. In this article, we adopt rigorous statistical testing framework test an individual gene...
Silicon is a potential substrate material for the large-areal-size mirrors of next-generation laser interferometer gravitational wave detector operated in cryogenics. nitride thin films uniformly deposited by chemical vapor deposition method on large-size silicon wafers common practice integrated circuit industry. We used plasma-enhanced to deposit and studied physical properties that are pertinent application mirror coatings detectors. measured analyzed structure, optical properties,...