A5066054055- Microtubule and mitosis dynamics
- Plant tissue culture and regeneration
- Innovations in Medical Education
- Vaccine Coverage and Hesitancy
- Education and Critical Thinking Development
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- Plant Virus Research Studies
- Genetic and Kidney Cyst Diseases
- Atherosclerosis and Cardiovascular Diseases
- Micro and Nano Robotics
- Cervical Cancer and HPV Research
- Systemic Lupus Erythematosus Research
- Photoreceptor and optogenetics research
- Photosynthetic Processes and Mechanisms
- Transgenic Plants and Applications
- Problem and Project Based Learning
The University of Tokyo
2016-2025
International Medical University
2011
The outer dynein arm (ODA) is a molecular complex that drives the beating motion of cilia/flagella. Chlamydomonas ODA composed three heavy chains (HCs), two ICs, and 11 light (LCs). Although three-dimensional (3D) structure whole has been investigated, 3D configurations ICs LCs are largely unknown. Here we identified positions using cryo-electron tomography structural labeling. We found these were all localized at root outer-inner (OID) linker, designated ODA-Beak complex. Of interest,...
Abstract Belimumab is an antibody targeting the cytokine B‐cell activating factor (BAFF), which crucial for B cell differentiation, and first molecularly targeted drug approved systemic lupus erythematosus (SLE). The primary endpoints have been met in clinical trials of belimumab involving patients with active SLE without severe organ complications, as well nephritis. In addition, effects preventing relapses reducing glucocorticoid use confirmed. Moreover, there were no significant...
ABSTRACT The docking complex is a molecular necessary for assembly of outer dynein arms (ODAs) on the axonemal doublet microtubules (DMTs) in cilia and flagella. hypothesized to be 24-nm ruler because ODAs align along DMTs with periodicity. In this study, we rigorously tested hypothesis using structural genetic methods. We found that can bind porcine periodicities even absence vitro. Using cryo-electron tomography labeling, observed took an unexpectedly flexible conformation did not lie...
Abstract Background The effectiveness of peer learning has been recognized and discussed by many scholars, implemented in the formal curriculums medical schools internationally. However, there is a general dearth studies measuring objective outcomes learning. Methods We investigated effect near-peer on tutee’s emotions its equivalence within curriculum clinical reasoning Problem Based Learning session Japanese school. Fourth-year students were assigned to group tutored 6 th -year or...