A5028799467- Salivary Gland Disorders and Functions
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Natural product bioactivities and synthesis
- Cytokine Signaling Pathways and Interactions
- Diabetes and associated disorders
- Psoriasis: Treatment and Pathogenesis
- Chronic Lymphocytic Leukemia Research
- Olfactory and Sensory Function Studies
- Renal Diseases and Glomerulopathies
- Cancer-related molecular mechanisms research
- Sphingolipid Metabolism and Signaling
Soochow University
2025
Fourth People's Hospital of Changzhou
2025
Zhejiang Chinese Medical University
2022-2023
Weatherford College
2023
Type 1 interferon (IFN-I)-related genes play a critical role in Sjögren's syndrome (SS). However, study on its and impact peripheral blood B cells of SS is limited. This investigated gene expression epigenetic changes IFI44L, analyzing correlation with disease activity clinical indicators. Differentially expressed (DEGs) were identified from the GSE199868 dataset, while IFN-I-related collected GeneCards. Intersection analysis revealed DEGs SS. ClueGO, Kyoto Encyclopedia Genes Genomes (KEGG)...
This study aimed to explore the mode of action Yiqiyangyinquyu prescription (YP) against Sjögren's syndrome (SS) by combining network pharmacology with molecular docking techniques. YP's active components and target proteins were identified using BATMAN-traditional Chinese medicine database. Concurrently, targets associated SS extracted from databases, including Genecards, Online Mendelian Inheritance in Man, Therapeutic Target Database. The standard then imported into STRING database...
Purpose: Sjogren's Syndrome (SS) is a systemic autoimmune disease primarily characterized by dysfunction of the exocrine glands. Research into etiology and pathogenesis salivary glands (SG) inflammation SS very limited. The aim this study was to identify potential pyroptosis-related genes in SG through bioinformatics analysis validation SS. Methods: GSE157159 dataset GSE159574 were downloaded from Gene Expression Omnibus (GEO). Differentially Expressed Genes (DEGs) used screen DEGs non-SS...
Systemic lupus erythematosus is a heterogeneous autoimmune disease in which skin involvement common manifestation. It currently thought that the photosensitivity of SLE associated with anti-SSA antibodies. This study aimed to expand current state knowledge surrounding molecular pathophysiology through Serum metabolomics analysis.The serum metabolites 23 cases skin-involved (SI) group, 14 no SI (NSI) and 30 healthy controls (HC) were analyzed by using UPLC-MS/MS technology, subgroup analysis...
Neuropsychiatric lupus (NPSLE) is one of the important manifestations systemic erythematosus. Previous studies mainly focused on disruption blood-brain barrier and production brain-reactive autoantibodies, However, there no comprehensive lipidomic analysis in NPSLE. Therefore, this research evaluated hippocampus liver NPSLE mice with mood disorders, to explore influence liver-brain axis disease.MRL/lpr MRL/mpj were respectively used as control groups. Behavioral tests disease characteristics...
Background: Abnormal B-cell homeostasis was significantly associated with the onset of SLE. This study analyzed peripheral blood CD19+B cell subsets' response characteristics in SLE patients receiving belimumab.Methods: We enrolled seven and six healthy volunteers CD19+ B subsets PBMCs before after one-month belimumab therapy using mass cytometry. In addition, we recruited (BAFF+, n=31), those not (BAFF-, n=12), controls (HC, n=15) to validate double-negative 2 B-cells (DN2) frequency its...