Daniel J. Chandra

ORCID: 0000-0003-0039-3177
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About
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Research Areas
  • Immune Cell Function and Interaction
  • Chemokine receptors and signaling
  • Chronic Myeloid Leukemia Treatments
  • CAR-T cell therapy research
  • Acute Myeloid Leukemia Research
  • Clinical Nutrition and Gastroenterology
  • Adenosine and Purinergic Signaling
  • Liver physiology and pathology
  • T-cell and B-cell Immunology
  • Blood groups and transfusion
  • Cognitive and developmental aspects of mathematical skills
  • Cell Adhesion Molecules Research
  • Neuropeptides and Animal Physiology
  • Biofield Effects and Biophysics
  • Advanced biosensing and bioanalysis techniques
  • Quantum Mechanics and Applications
  • Cancer Cells and Metastasis
  • Immunotherapy and Immune Responses
  • Mathematics Education and Teaching Techniques
  • Occupational Health and Safety Management
  • Cytokine Signaling Pathways and Interactions
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • HIV Research and Treatment
  • Chemotherapy-induced cardiotoxicity and mitigation
  • Retinoids in leukemia and cellular processes

Oregon Health & Science University
2023-2025

State University of Malang
2023

University of Portland
2023

Atma Jaya Catholic University of Indonesia
2021

Politeknik Negeri Semarang
2020

State University of Semarang
2020

Memorial Sloan Kettering Cancer Center
2018-2019

Georgia Regents Medical Center
2016

Emory University
2016

Augusta University
2015

Abstract Background: NCAM1 (CD56) is a neural cell adhesion molecule that expressed on immune cells including NK cells, T dendric and monocytes. Acute myeloid leukemia (AML) patients also aberrantly express in around 30% of cases which may impact treatment response. Our group recently found CD56 expression blasts associated with worse overall survival to the BCL2 inhibitor, Venetoclax (VEN), VEN combined hypomethylating agents or JAK Ruxolitinib. Within molecular prognostic risk score (mPRS)...

10.1158/1538-7445.am2025-721 article EN Cancer Research 2025-04-21

The goal of allogeneic bone marrow transplantation (allo-BMT) is elimination leukemia cells through the graft-versus-leukemia (GvL) activity donor cells, while limiting graft-versus-host disease (GvHD). Immune checkpoint pathways regulate GvL and GvHD activities, but blocking antibodies or genetic inactivation these can cause lethal GVHD. Vasoactive intestinal peptide (VIP) an immunosuppressive neuropeptide that regulates coinhibitory pathways; its role in allo-BMT has not been studied. We...

10.1158/0008-5472.can-16-0427 article EN Cancer Research 2016-09-27

Tujuan penelitian ini adalah mengkaji kinerja turbin angin savonius darrieus tipe cebong dimana diberikan variasi kecepatan (m/s) yang digunakan untuk memutar sudu diukur menggunakan anemometer. Tahapan meliputi pembuatan cebong, perakitan savonius-darreus dan pengujian karakteristik cebong. Hasil dari dengan 6 m/s, 7m/s, 8 9 m/s diperoleh torsi tertinggi dihasilkan sebesar 0,924 Nm pada putaran 45,3 rpm, m/s. Daya kinetik 220,450 Watt 9m/s. mekanik 5,708 65,7 rpm Turbin savonius-darrieus...

10.32497/nciet.v1i1.169 article ID Prosiding Seminar Nasional NCIET 2020-12-20

Abstract Chronic graft versus host disease (cGVHD) continues to be a major source of morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HSCT) patients, current therapies are limited by severe toxicity immunosuppression. Numerous studies have confirmed the efficacy extracorporeal photopheresis (ECP) treatment steroid refractory cGVHD without inducing Although posited role for immunoregulatory cells mechanism ECP, immunological effects ECP not completely understood....

10.4049/jimmunol.196.supp.140.18 article EN The Journal of Immunology 2016-05-01

<div>Abstract<p>The goal of allogeneic bone marrow transplantation (allo-BMT) is elimination leukemia cells through the graft-versus-leukemia (GvL) activity donor cells, while limiting graft-versus-host disease (GvHD). Immune checkpoint pathways regulate GvL and GvHD activities, but blocking antibodies or genetic inactivation these can cause lethal GVHD. Vasoactive intestinal peptide (VIP) an immunosuppressive neuropeptide that regulates coinhibitory pathways; its role in...

10.1158/0008-5472.c.6508566.v1 preprint EN 2023-03-31

<p>Supplementary Methods, Supplementary Figure S1, Transplantation of VIP-KO cells or treatment with VIPhyb did not increase GVHD; S2, suppress lymphoblastic leukemia growth in vitro; S3, VIPhyb-treatment reprogramed homing patterns donor T-cells allo-BMT recipients; S4, enhanced expression co-stimulatory and effector molecules after allo-BMT; S5, treated recipients were resistant to re-challenge; S6, led increased reduced co-inhibitory S7, levels TCM Table S1. Mice GvL had distinct...

10.1158/0008-5472.22412955 preprint EN cc-by 2023-03-31

<p>Supplementary Methods, Supplementary Figure S1, Transplantation of VIP-KO cells or treatment with VIPhyb did not increase GVHD; S2, suppress lymphoblastic leukemia growth in vitro; S3, VIPhyb-treatment reprogramed homing patterns donor T-cells allo-BMT recipients; S4, enhanced expression co-stimulatory and effector molecules after allo-BMT; S5, treated recipients were resistant to re-challenge; S6, led increased reduced co-inhibitory S7, levels TCM Table S1. Mice GvL had distinct...

10.1158/0008-5472.22412955.v1 preprint EN cc-by 2023-03-31

The concept of fractions given in learning is the part whole and unit.The development student's concepts can be built through fraction schemes.A partitive scheme a that estimates size form non-units to not partitioned.The using uses strong understanding unit partwhole fractions.This study aims photograph process developing students' mental actions constructing scheme. .This research method qualitative approach with case type on students who are able express schemes.The stages data analysis...

10.47750/pegegog.13.04.29 article EN Pegem Journal of Education and Instruction 2023-08-01

<div>Abstract<p>The goal of allogeneic bone marrow transplantation (allo-BMT) is elimination leukemia cells through the graft-versus-leukemia (GvL) activity donor cells, while limiting graft-versus-host disease (GvHD). Immune checkpoint pathways regulate GvL and GvHD activities, but blocking antibodies or genetic inactivation these can cause lethal GVHD. Vasoactive intestinal peptide (VIP) an immunosuppressive neuropeptide that regulates coinhibitory pathways; its role in...

10.1158/0008-5472.c.6508566 preprint EN 2023-03-31

Mechanisms leading to the loss of crypt base intestinal stem cells (ISCs) and their Paneth cell (PC) niche in GI GVHD are poorly understood. To assess relationship between ISC injury, we evaluated compartment epithelial regeneration after MHC- miHA-mismatched experimental allo-BMT. Lgr5+ ISCs were rapidly depleted pretransplant conditioning, but quickly recovered recipients T-cell-depleted (TCD) BMT by day 10 post-BMT. However, failed recover mice. preceded damage PC niche, suggesting as...

10.1016/j.bbmt.2017.12.639 article EN cc-by-nc-nd Biology of Blood and Marrow Transplantation 2018-02-03

Following our previous frugal experiments of low-intensity laser irradiation on potable water, allow us to present a few considerations why this writer thinks that these are pathway towards realistic tunneling experiment especially in the context quantum (liquid) crystalline Cosmology. First all, recall preceding articles CTPNP 2019, and also Octogon Magazine 2022 regarding exact correspondence between Maxwell equations classical electrodynamics Dirac equations. What is more interesting it...

10.54216/jcfa.020104 article EN 2022-01-01
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